(Q34106564)

31 July 2017

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title

Huntington's disease: the challenge for cell biologists (English)

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31 July 2017

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A J Tobin

1

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31 July 2017

E R Signer

series ordinal

2

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31 July 2017

publication date

1 December 2000

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31 July 2017

published in

Trends in Cell Biology

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31 July 2017

volume

10

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31 July 2017

issue

12

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31 July 2017

page(s)

531-536

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Trinucleotide repeats in neurogenetic disorders

31 July 2017

cites work

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Intranuclear neuronal inclusions: a common pathogenic mechanism for glutamine-repeat neurodegenerative diseases?

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

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Differential expression of normal and mutant Huntington's disease gene alleles

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Caspases and neurodegeneration: on the cutting edge of new therapeutic approaches.

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Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

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7 January 2021

Nuclear targeting of mutant Huntingtin increases toxicity

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A cellular model that recapitulates major pathogenic steps of Huntington's disease

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7 January 2021

Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology

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7 January 2021

Transglutaminase aggregates huntingtin into nonamyloidogenic polymers, and its enzymatic activity increases in Huntington's disease brain nuclei

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7 January 2021

Localization of rabbit huntingtin using a new panel of monoclonal antibodies

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7 January 2021

Mutant huntingtin forms in vivo complexes with distinct context-dependent conformations of the polyglutamine segment

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7 January 2021

Genetic neurodegenerative diseases: the human illness and transgenic models

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7 January 2021

Recent insights into the molecular pathogenesis of Huntington disease

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7 January 2021

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

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7 January 2021

Aggresomes: a cellular response to misfolded proteins

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7 January 2021

Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

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7 January 2021

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

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7 January 2021

Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

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7 January 2021

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

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7 January 2021

Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

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7 January 2021

Epidermal immunization by a needle-free powder delivery technology: Immunogenicity of influenza vaccine and protection in mice

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7 January 2021

Expression of polyglutamine-expanded Huntingtin activates the SEK1-JNK pathway and induces apoptosis in a hippocampal neuronal cell line

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7 January 2021

Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease

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7 January 2021

Mitochondria in neurodegeneration: bioenergetic function in cell life and death

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7 January 2021

Decrease in striatal enkephalin mRNA in mouse models of Huntington's disease

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7 January 2021

Energetics in the pathogenesis of neurodegenerative diseases

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7 January 2021

10.1016/S0962-8924(00)01853-5

Identifiers

DOI

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31 July 2017

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