(Q34107140)

31 July 2017

1 reference

title

Programming of erythromycin biosynthesis by a modular polyketide synthase (English)

1 reference

31 July 2017

1 reference

David E Cane

1

1 reference

31 July 2017

language of work or name

English

0 references

publication date

3 June 2010

1 reference

Journal of Biological Chemistry

31 July 2017

published in

1 reference

31 July 2017

volume

285

1 reference

31 July 2017

issue

36

1 reference

31 July 2017

page(s)

27517-27523

1 reference

Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism

31 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

The biochemical basis for stereochemical control in polyketide biosynthesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

Structures and mechanisms of polyketide synthases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

The chemical biology of modular biosynthetic enzymes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

The biosynthetic logic of polyketide diversity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

Biosynthesis of polyketide synthase extender units

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

Towards prediction of metabolic products of polyketide synthases: an in silico analysis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

Revisiting the modularity of modular polyketide synthases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

Crystal Structure of the Erythromycin Polyketide Synthase Dehydratase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

The multienzyme architecture of eukaryotic fatty acid synthases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

The crystal structure of a mammalian fatty acid synthase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

Advances in polyketide synthase structure and function.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

Solution structure and proposed domain-domain recognition interface of an acyl carrier protein domain from a modular polyketide synthase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

Structural and Mechanistic Analysis of Protein Interactions in Module 3 of the 6-Deoxyerythronolide B Synthase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

A tylosin ketoreductase reveals how chirality is determined in polyketides

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

Structure-based dissociation of a type I polyketide synthase module

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

Structural basis for substrate delivery by acyl carrier protein in the yeast fatty acid synthase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

Structure and mechanism of the 6-deoxyerythronolide B synthase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

Extender unit and acyl carrier protein specificity of ketosynthase domains of the 6-deoxyerythronolide B synthase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

Reconstituting modular activity from separated domains of 6-deoxyerythronolide B synthase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

An efficient method for creation and functional analysis of libraries of hybrid type I polyketide synthases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

The structure of docking domains in modular polyketide synthases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

Quantitative analysis of loading and extender acyltransferases of modular polyketide synthases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

Mechanism of the beta-ketoacyl synthase reaction catalyzed by the animal fatty acid synthase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

5 July 2018

Avermectin Biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

Polyketide biosynthesis: a millennium review

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

Tolerance and specificity of polyketide synthases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

Post-translational modification of polyketide and nonribosomal peptide synthases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

Mapping of functional interactions between domains of the animal fatty acid synthase by mutant complementation in vitro

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

An erythromycin analog produced by reprogramming of polyketide synthesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

Stereochemical problems in macrolide antibiotics

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

6-Deoxyerythronolide-B synthase 2 from Saccharopolyspora erythraea. Cloning of the structural gene, sequence analysis and inferred domain structure of the multifunctional enzyme

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

The Biosynthesis of Long-Chain Fatty Acids. Incorporation of Radioactivity from Stereospecifically Tritiated Malonyl Thiol Esters, and the Stereochemistry of the Acetyl-CoA Carboxylase Reaction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

The Biosynthesis of Long-Chain Fatty Acids. Stereochemical Differentiation in the Enzymic Incorporation of Chiral Acetates

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2934617

Intermodular communication in modular polyketide synthases: structural and mutational analysis of linker mediated protein-protein recognition

5 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.144618

Selective protein-protein interactions direct channeling of intermediates between polyketide synthase modules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.144618

The DEBS paradigm for type I modular polyketide synthases and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.144618

4-[2-(2-amino-2-oxoethyl)-2,7-dihydroxy-4-oxochroman-5-yl]-3-hydroxybut-2-enoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.144618

A polylinker approach to reductive loop swaps in modular polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.144618

Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.144618

Evidence for two catalytically independent clusters of active sites in a functional modular polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.144618

Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.144618

Biochemical analysis of the substrate specificity of the beta-ketoacyl-acyl carrier protein synthase domain of module 2 of the erythromycin polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.144618

Mechanistic analysis of acyl transferase domain exchange in polyketide synthase modules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.144618

Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.144618

Short-chain dehydrogenases/reductases (SDRs).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.144618

Erythromycin biosynthesis. The 4-pro-S hydride of NADPH is utilized for ketoreduction by both module 5 and module 6 of the 6-deoxyerythronolide B synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.144618

A model of structure and catalysis for ketoreductase domains in modular polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.144618

Conserved amino acid residues correlating with ketoreductase stereospecificity in modular polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.144618

The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.144618

Predicting the nature and timing of epimerisation on a modular polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.144618

Stereochemistry of catalysis by the ketoreductase activity in the first extension module of the erythromycin polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.144618

The structure of (3R)-hydroxyacyl-acyl carrier protein dehydratase (FabZ) from Pseudomonas aeruginosa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.144618

Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.144618

The Molecular Basis of Celmer's Rules: The Stereochemistry of the Condensation Step in Chain Extension on the Erythromycin Polyketide Synthase†

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R110.144618

Molecular Basis of Celmer's Rules: Stereochemistry of Catalysis by Isolated Ketoreductase Domains from Modular Polyketide Synthases

21 January 2018

1 reference

12 December 2020

MACROLIDE STEREOCHEMISTRY. 3. A CONFIGURATIONAL MODEL FOR MACROLIDE ANTIBIOTICS

1 reference

12 December 2020

Complex enzymes in microbial natural product biosynthesis, part B: polyketides, aminocoumarins and carbohydrates. Preface

1 reference

12 December 2020

Mutagenesis of the dehydratase active site in the erythromycin-producing polyketide synthase

1 reference

12 December 2020

Stereospecific acyl transfers on the erythromycin-producing polyketide synthase

1 reference

12 December 2020

Dissecting and exploiting intermodular communication in polyketide synthases

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.R110.144618

1 reference

31 July 2017

1 reference

31 July 2017

1 reference