(Q34107757)

31 July 2017

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title

Prodrug/drug sensitivity gene therapy: current status (English)

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31 July 2017

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Smythe WR

1

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31 July 2017

publication date

1 January 2000

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31 July 2017

published in

Current Oncology Reports

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31 July 2017

volume

2

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31 July 2017

issue

1

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31 July 2017

page(s)

17-22

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A phase I trial of in vivo gene therapy with the herpes simplex thymidine kinase/ganciclovir system for the treatment of refractory or recurrent ovarian cancer

31 July 2017

cites work

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12 December 2020

Treatment of experimental human mesothelioma using adenovirus transfer of the herpes simplex thymidine kinase gene

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12 December 2020

Double suicide gene (cytosine deaminase and herpes simplex virus thymidine kinase) but not single gene transfer allows reliable elimination of tumor cells in vivo

1 reference

12 December 2020

Adenoviral-mediated thymidine kinase gene transfer into the primate brain followed by systemic ganciclovir: pathologic, radiologic, and molecular studies

1 reference

12 December 2020

Adenovirus-mediated herpes simplex virus thymidine kinase/ganciclovir gene therapy in patients with localized malignancy: results of a phase I clinical trial in malignant mesothelioma.

1 reference

12 December 2020

Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase

1 reference

12 December 2020

Intracranial administration of adenovirus expressing HSV-TK in combination with ganciclovir produces a dose-dependent, self-limiting inflammatory response.

1 reference

12 December 2020

Regional 'pro-drug' gene therapy: intravenous administration of an adenoviral vector expressing the E. coli cytosine deaminase gene and systemic administration of 5-fluorocytosine suppresses growth of hepatic metastasis of colon carcinoma

1 reference

12 December 2020

Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies

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12 December 2020

Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells.

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12 December 2020

Gap junctions play a role in the 'bystander effect' of the herpes simplex virus thymidine kinase/ganciclovir system in vitro

1 reference

12 December 2020

In vitro and in vivo antitumor effects of retrovirus-mediated herpes simplex thymidine kinase gene-transfer in human medulloblastoma

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12 December 2020

In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors

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12 December 2020

Expression of costimulatory molecules: B7 and ICAM up-regulation after treatment with a suicide gene

1 reference

12 December 2020

Use of recombinant adenovirus to transfer the herpes simplex virus thymidine kinase (HSVtk) gene to thoracic neoplasms: an effective in vitro drug sensitization system

1 reference

12 December 2020

Human malignant brain tumor response to herpes simplex thymidine kinase (HSVtk)/ganciclovir gene therapy

1 reference

12 December 2020

Mechanism of 'bystander effect' killing in the herpes simplex thymidine kinase gene therapy model of cancer treatment

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12 December 2020

Liposomal delivery of the herpes simplex virus thymidine kinase gene in glioma: improvement of cell sensitization to ganciclovir.

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12 December 2020

Escherichia coli gpt gene sensitizes rat glioma cells to killing by 6-thioxanthine or 6-thioguanine.

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12 December 2020

Herpes simplex virus thymidine kinase/ganciclovir-mediated killing of tumor cell induces tumor-specific cytotoxic T cells in mice.

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12 December 2020

Virally directed cytosine deaminase/5-fluorocytosine gene therapy enhances radiation response in human cancer xenografts

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12 December 2020

Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells

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12 December 2020

Gene-Directed Enzyme Prodrug Therapy

1 reference

12 December 2020

Sensitization of human breast cancer cells to cyclophosphamide and ifosfamide by transfer of a liver cytochrome P450 gene.

1 reference

12 December 2020

Regional delivery of an adenovirus vector containing the Escherichia coli cytosine deaminase gene to provide local activation of 5-fluorocytosine to suppress the growth of colon carcinoma metastatic to liver.

1 reference

12 December 2020

Gene-directed enzyme prodrug therapy: quantitative bystander cytotoxicity and DNA damage induced by CB1954 in cells expressing bacterial nitroreductase

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12 December 2020

Long-term rat survival after malignant brain tumor regression by retroviral gene therapy.

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12 December 2020

Safety of intrapleurally administered recombinant adenovirus carrying herpes simplex thymidine kinase DNA followed by ganciclovir therapy in nonhuman primates

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12 December 2020

Ganciclovir-induced ablation non-proliferating thyrocytes expressing herpesvirus thymidine kinase occurs by p53-independent apoptosis

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12 December 2020

Prodrug-activated gene therapy: involvement of an immunological component in the "bystander effect".

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12 December 2020

Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo

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12 December 2020

Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component.

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12 December 2020

Gene therapy in brain tumours: implications of the size of glioblastoma on its curability

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12 December 2020

In situ gene therapy for adenocarcinoma of the prostate: a phase I clinical trial.

1 reference

12 December 2020

Tumor cell bystander killing in colonic carcinoma utilizing the Escherichia coli DeoD gene to generate toxic purines

1 reference

12 December 2020

Gene-directed enzyme prodrug therapy with a mustard prodrug/carboxypeptidase G2 combination

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12 December 2020

Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins

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12 December 2020

Adenoviral-mediated delivery of herpes simplex virus thymidine kinase results in tumor reduction and prolonged survival in a SCID mouse model of human ovarian carcinoma

1 reference

12 December 2020

In vivo analysis of the 'bystander effect': a cytokine cascade

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12 December 2020

A comparison of the properties of different retroviral vectors containing the murine tyrosinase promoter to achieve transcriptionally targeted expression of the HSVtk or IL-2 genes

1 reference

12 December 2020

10.1007/S11912-000-0006-Z

Identifiers

DOI

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Dimensions Publication ID

31 July 2017

1017711362

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