(Q34112588)

31 July 2017

title

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease (English)

1 reference

31 July 2017

1 reference

4

Leonard Petrucelli

1 reference

31 July 2017

12

Ted M Dawson

1 reference

31 July 2017

5

Andrew B. West

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20729864

20 June 2024

author name string

Byoung Dae Lee

1

1 reference

31 July 2017

Joo-Ho Shin

2

1 reference

31 July 2017

Jackalina VanKampen

3

1 reference

31 July 2017

Han Seok Ko

6

1 reference

31 July 2017

Yun-Il Lee

7

1 reference

31 July 2017

Kathleen A. Maguire-Zeiss

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20729864

20 June 2024

William J. Bowers

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20729864

20 June 2024

Howard J. Federoff

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20729864

20 June 2024

Valina L. Dawson

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20729864

20 June 2024

language of work or name

English

0 references

publication date

22 August 2010

1 reference

full work available at URL

31 July 2017

https://europepmc.org/articles/pmc2935926?pdf=render

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20729864

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20729864/?tool=EBI

20 June 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20729864

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20729864/pdf/?tool=EBI

20 June 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20729864

https://europepmc.org/articles/PMC2935926

20 June 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20729864

https://europepmc.org/articles/PMC2935926?pdf=render

20 June 2024

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20729864

http://www.nature.com/articles/nm.2199.pdf

20 June 2024

https://api.crossref.org/works/10.1038/NM.2199

1 reference

http://www.nature.com/articles/nm.2199

20 June 2024

1 reference

https://api.crossref.org/works/10.1038/NM.2199

20 June 2024

1 reference

31 July 2017

volume

16

1 reference

31 July 2017

issue

9

1 reference

31 July 2017

page(s)

998-1000

1 reference

Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease

31 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935926

Molecular pathogenesis of Parkinson disease: insights from genetic studies

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935926

Identification of compounds that inhibit the kinase activity of leucine-rich repeat kinase 2.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935926

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935926

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935926

Clinical and pathologic features of families with LRRK2-associated Parkinson's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935926

Kinase activity of mutant LRRK2 mediates neuronal toxicity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935926

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935926

LRRK2 in Parkinson's disease: protein domains and functional insights

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935926

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935926

Leucine-rich repeat kinase 2 mutants I2020T and G2019S exhibit altered kinase inhibitor sensitivity.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935926

Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935926

Inhibition of glycogen synthase kinase-3beta protects dopaminergic neurons from MPTP toxicity

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935926

The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935926

Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935926

28 October 2018

Identifiers

DOI

10.1038/NM.2199

1 reference

31 July 2017

1 reference

31 July 2017

1 reference