(Q34112849)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20590584%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

title

Microsomal prostaglandin E synthase-1 contributes to ischaemic excitotoxicity through prostaglandin E2 EP3 receptors (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20590584%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20590584%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

author name string

H Tanji

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20590584%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

A Ota

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20590584%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Y Hirayama

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20590584%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

S Uematsu

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20590584%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

S Akira

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20590584%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Y Sasaki

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20590584%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

language of work or name

English

0 references

publication date

1 June 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20590584%20AND%20SRC:MED&resulttype=core&format=json

British Journal of Pharmacology

6 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20590584%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

volume

160

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20590584%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20590584%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

page(s)

847-859

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20590584%20AND%20SRC:MED&resulttype=core&format=json

Microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are both required for ischaemic excitotoxicity

6 February 2020

cites work

1 reference

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MARCKS regulates lamellipodia formation induced by IGF-I via association with PIP2 and beta-actin at membrane microdomains.

5 July 2018

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Reduced acute brain injury in PGE2 EP3 receptor-deficient mice after cerebral ischemia.

5 July 2018

1 reference

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Postconditioning with isoflurane reduced ischemia-induced brain injury in rats.

5 July 2018

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Misoprostol, an anti-ulcer agent and PGE2 receptor agonist, protects against cerebral ischemia

5 July 2018

1 reference

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Mouse EP3 alpha, beta, and gamma receptor variants reduce tumor cell proliferation and tumorigenesis in vivo.

5 July 2018

1 reference

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Neurotransmitters and pathophysiology of stroke: evidence for the release of glutamate and other transmitters/mediators in animals and humans.

5 July 2018

1 reference

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Stimulation of prostaglandin E2-EP3 receptors exacerbates stroke and excitotoxic injury.

5 July 2018

1 reference

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Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935993

Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection

5 July 2018

1 reference

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Involvement of Rho-kinase in contraction of guinea-pig aorta induced by prostanoid EP3 receptor agonists

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935993

Characteristics of thermoregulatory and febrile responses in mice deficient in prostaglandin EP1 and EP3 receptors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935993

Host prostaglandin E(2)-EP3 signaling regulates tumor-associated angiogenesis and tumor growth

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935993

5 July 2018

Prostaglandin E synthase

2 references

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5 July 2018

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Prostaglandin receptors: advances in the study of EP3 receptor signaling

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935993

The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935993

Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935993

Intracellular Ca2+ increase in neuro-2A cells and rat astrocytes following stimulation of bradykinin B2 receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935993

Inhibitory effect of a prostaglandin E receptor subtype EP(1) selective antagonist, ONO-8713, on development of azoxymethane-induced aberrant crypt foci in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935993

The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935993

Prostanoid receptors: structures, properties, and functions

5 July 2018

2 references

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5 July 2018

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Inflammatory mediators and stroke: new opportunities for novel therapeutics

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935993

Pathobiology of ischaemic stroke: an integrated view

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935993

The changing landscape of ischaemic brain injury mechanisms.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935993

Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935993

Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3

5 July 2018

1 reference

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Cyclooxygenases and the central nervous system

5 July 2018

1 reference

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Prostaglandin E receptor EP3 subtype induces neurite retraction via small GTPase Rho.

5 July 2018

1 reference

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Mouse prostaglandin E receptor EP3 subtype mediates calcium signals via Gi in cDNA-transfected Chinese hamster ovary cells

5 July 2018

1 reference

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Postischemic production of eicosanoids in gerbil brain

5 July 2018

1 reference

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Correlation between amino acid release and neuropathologic outcome in rat brain following middle cerebral artery occlusion

5 July 2018

1 reference

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Prostaglandin EP1 receptor contributes to excitotoxicity and focal ischemic brain damage

5 July 2018

1 reference

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Involvement of gamma protein kinase C in estrogen-induced neuroprotection against focal brain ischemia through G protein-coupled estrogen receptor

21 January 2018

1 reference

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Microglia-specific expression of microsomal prostaglandin E2 synthase-1 contributes to lipopolysaccharide-induced prostaglandin E2 production.

21 January 2018

1 reference

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Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicity

21 January 2018

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Neuroprotective potential of fasudil mesylate in brain ischemia-reperfusion injury of rats

21 January 2018

1 reference

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Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia.

21 January 2018

1 reference

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Rho-kinase mediates spinal nitric oxide formation by prostaglandin E2 via EP3 subtype.

21 January 2018

1 reference

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A transient brain ischemia- and bacterial endotoxin-induced glial iNOS expression and NO-induced neuronal apoptosis

21 January 2018

1 reference

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Amelioration of hippocampal neuronal damage after transient forebrain ischemia in cyclooxygenase-2-deficient mice

21 January 2018

1 reference

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Use of an optimized transient occlusion of the middle cerebral artery protocol for the mouse stroke model.

21 January 2018

1 reference

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Microglial expression of prostaglandin EP3 receptor in excitotoxic lesions in the rat striatum

21 January 2018

1 reference

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Prostaglandin E2 induced caspase-dependent apoptosis possibly through activation of EP2 receptors in cultured hippocampal neurons

21 January 2018

1 reference

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The effect of head cooling on the physiological responses and resultant neural damage to global hemispheric hypoxic ischemia in prostaglandin E2 treated rats

21 January 2018

1 reference

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Lipopolysaccharide-dependent prostaglandin E(2) production is regulated by the glutathione-dependent prostaglandin E(2) synthase gene induced by the Toll-like receptor 4/MyD88/NF-IL6 pathway

21 January 2018

1 reference

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Fasudil, a Rho kinase (ROCK) inhibitor, protects against ischemic neuronal damage in vitro and in vivo by acting directly on neurons

21 January 2018

1 reference

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Guide to Receptors and Channels (GRAC), 4th Edition

21 January 2018

1 reference

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EP1- and EP3-receptors mediate prostaglandin E2-induced constriction of porcine large cerebral arteries

28 October 2018

1 reference

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Identification of specific EP receptors responsible for the hemodynamic effects of PGE2.

28 October 2018

1 reference

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Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2935993

Prostaglandin EP4 receptor agonist protects against acute neurotoxicity

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20590584

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Immunohistochemical localization of prostaglandin EP3 receptor in the rat nervous system

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20590584

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/J.1476-5381.2010.00711.X

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20590584%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20590584%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

PubMed publication ID

20590584

1 reference