(Q34116998)

English

Protein kinase C delta (PKCδ) affects proliferation of insulin-secreting cells by promoting nuclear extrusion of the cell cycle inhibitor p21Cip1/WAF1.

scientific article

In more languages

default for all languages

No label defined

No description defined

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Protein kinase C delta (PKCδ) affects proliferation of insulin-secreting cells by promoting nuclear extrusion of the cell cycle inhibitor p21Cip1/WAF1. (English)

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

1 reference

based on heuristic

inferred from title

object named as

Fatima Bosch

9

0 references

Hans-Ulrich Häring

11

object named as

Hans-Ulrich Häring

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

author name string

Felicia Ranta

1

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Johannes Leveringhaus

2

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Dorothea Theilig

3

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Gabriele Schulz-Raffelt

4

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Anita M Hennige

5

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Dominic G Hildebrand

6

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

René Handrick

7

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Verena Jendrossek

8

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Klaus Schulze-Osthoff

10

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Susanne Ullrich

12

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

language of work or name

0 references

publication date

27 December 2011

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

12

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

e28828

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

copyright license

Creative Commons Attribution 4.0 International

27 December 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

P21cip-overexpression in the mouse beta cells leads to the improved recovery from streptozotocin-induced diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

PKC Delta (PKCdelta) promotes tumoral progression of human ductal pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

Absence of p53-dependent apoptosis combined with nonhomologous end-joining deficiency leads to a severe diabetic phenotype in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

Deletion of the mitochondrial flavoprotein apoptosis inducing factor (AIF) induces beta-cell apoptosis and impairs beta-cell mass

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

The PKCdelta -Abl complex communicates ER stress to the mitochondria - an essential step in subsequent apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

CDK inhibitors: cell cycle regulators and beyond

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

TACC3 depletion sensitizes to paclitaxel-induced cell death and overrides p21WAF-mediated cell cycle arrest

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

Regulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1 by protein kinase Cdelta-mediated phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

The multiple battles fought by anti-apoptotic p21.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

Post-transcriptional destabilization of p21cip1 by protein kinase C in fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

Dexamethasone induces cell death in insulin-secreting cells, an effect reversed by exendin-4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

Serum- and glucocorticoid-inducible kinase 1 (SGK1) mediates glucocorticoid-induced inhibition of insulin secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

The enigmatic protein kinase Cdelta: complex roles in cell proliferation and survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

PDK1-dependent activation of atypical PKC leads to degradation of the p21 tumour modifier protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

Nuclear import of PKCdelta is required for apoptosis: identification of a novel nuclear import sequence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

Identification of the nuclear localization signal of p21(cip1) and consequences of its mutation on cell proliferation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

Protein kinase Cdelta activation by interleukin-1beta stabilizes inducible nitric-oxide synthase mRNA in pancreatic beta-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

Rottlerin, a novel protein kinase inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246440

5 July 2018

Type 2 diabetes-a matter of beta-cell life and death?

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028828

21 January 2018

Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028828

21 January 2018

CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028828

21 January 2018

Mitochondrial dysfunction: glucokinase downregulation lowers interaction of glucokinase with mitochondria, resulting in apoptosis of pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028828

21 January 2018

Deletion of protein kinase Cδ in mice modulates stability of inflammatory genes and protects against cytokine-stimulated beta cell death in vitro and in vivo.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028828

21 January 2018

Inhibition of protein kinase C delta protects rat INS-1 cells against interleukin-1beta and streptozotocin-induced apoptosis

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028828

21 January 2018

Overexpression of kinase-negative protein kinase Cdelta in pancreatic beta-cells protects mice from diet-induced glucose intolerance and beta-cell dysfunction

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028828

21 January 2018

Two Faces of Protein Kinase Cδ: The Contrasting Roles of PKCδ in Cell Survival and Cell Death

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028828

21 January 2018

The cell cycle inhibitory protein p21cip is not essential for maintaining beta-cell cycle arrest or beta-cell function in vivo.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028828

21 January 2018

Regulation of protein kinase C delta by phorbol ester, endothelin-1, and platelet-derived growth factor in cardiac myocytes

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028828

21 January 2018

Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028828

21 January 2018

Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028828

21 January 2018

Identification and subcellular characterization of protein kinase-C isoforms in insulinoma beta-cells and whole islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/22216119

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase Cdelta plays a non-redundant role in insulin secretion in pancreatic beta cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22216119

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress induces p21 expression in pancreatic islet cells: possible implication in beta-cell dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/22216119

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0028828

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

2011PLoSO...628828R

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q34116998&oldid=1953927695"