(Q34119554)

31 July 2017

Recent advances in the development of telomerase inhibitors for the treatment of cancer (English)

1 reference

31 July 2017

Perry PJ

1

1 reference

PubMed ID

11139836

31 July 2017

Jenkins TC

series ordinal

2

1 reference

PubMed ID

11139836

31 July 2017

language of work or name

English

0 references

publication date

1 December 1999

1 reference

Expert Opinion on Investigational Drugs

31 July 2017

1 reference

31 July 2017

8

1 reference

31 July 2017

1981-2008

1 reference

31 July 2017

12

1 reference

Identification of a specific telomere terminal transferase activity in Tetrahymena extracts

31 July 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Telomere length regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Structure and function of telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Heterogeneity in telomere length of human chromosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Origin of Concatemeric T7DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

TRF2 Protects Human Telomeres from End-to-End Fusions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

DNA damage and repair in telomeres: relation to aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Telomeres shorten during ageing of human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Evidence for a critical telomere length in senescent human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Normal human chromosomes have long G-rich telomeric overhangs at one end

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Telomerase catalytic subunit homologs from fission yeast and human

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Human telomerase contains evolutionarily conserved catalytic and structural subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

The RNA component of human telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Telomerase activity in human ovarian carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Agents that target telomerase and telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Essential role of mouse telomerase in highly proliferative organs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Severe growth defect in mouse cells lacking the telomerase RNA component.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Extension of life-span by introduction of telomerase into normal human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Absence of cancer-associated changes in human fibroblasts immortalized with telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Telomerase activity is sufficient to allow transformed cells to escape from crisis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Creation of human tumour cells with defined genetic elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Preclinical and clinical strategies for development of telomerase and telomere inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Telomerase and early detection of cancer: a National Cancer Institute workshop

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Telomere loss in cells treated with cisplatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Inhibition of telomerase increases the susceptibility of human malignant glioblastoma cells to cisplatin-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Inhibition of human telomerase by a retrovirus expressing telomeric antisense RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Inhibition of human telomerase by 2'-O-methyl-RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Synthetic 2'-O-methyl-modified hammerhead ribozymes targeted to the RNA component of telomerase as sequence-specific inhibitors of telomerase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Inhibition of telomerase activity of melanoma cells in vitro by antisense oligonucleotides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

A hexameric phosphorothioate oligonucleotide telomerase inhibitor arrests growth of Burkitt's lymphoma cells in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Inhibition of human telomerase activity by peptide nucleic acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Telomerase protein rather than its RNA is the target of phosphorothioate-modified oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

21 January 2018

Myc activates telomerase

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Direct activation of TERT transcription by c-MYC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Telomerase activity in human leukemic cell lines is inhibited by antisense pentadecadeoxynucleotides targeted against c-myc mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

In vivo studies with antisense oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Restoration of the cellular senescence program and repression of telomerase by human chromosome 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Telomerase repressor sequences on chromosome 3 and induction of permanent growth arrest in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Repression of the telomerase catalytic subunit by a gene on human chromosome 3 that induces cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

The effects of nucleoside analogs on telomerase and telomeres in Tetrahymena

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Transplacental effects of 3'-azido-2',3'-dideoxythymidine (AZT): tumorigenicity in mice and genotoxicity in mice and monkeys.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

1,4- and 2,6-disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Telomeres: no end in sight

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine-guanine base pairs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

The DNA structures at the ends of eukaryotic chromosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Crystal structure of four-stranded Oxytricha telomeric DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Solution structure of the human telomeric repeat d[AG3(T2AG3)3] G-tetraplex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

The high-resolution crystal structure of a parallel-stranded guanine tetraplex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

The crystal structure of a parallel-stranded guanine tetraplex at 0.95 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

G-quartet structures in telomeric DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

1H NMR spectroscopy of DNA triplexes and quadruplexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Telomere structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Control of telomere length by the human telomeric protein TRF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Modulation of telomerase activity by telomere DNA-binding proteins in Oxytricha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Inhibition of telomerase by G-quartet DNA structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Multiple pathways for the regulation of telomerase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

The thermodynamics of DNA structures that contain lesions or guanine tetrads

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

A DNA polymerase stop assay for G-quadruplex-interactive compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Spectroscopic recognition of guanine dimeric hairpin quadruplexes by a carbocyanine dye.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Anthracene-9,10-diones as potential anticancer agents: bacterial mutation studies of amido-substituted derivatives reveal an unexpected lack of mutagenicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Porphyrin binding to quadrupled T4G4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Fluorescent dyes specific for quadruplex DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

2,7-Disubstituted amidofluorenone derivatives as inhibitors of human telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

NMR-Based model of a telomerase-inhibiting compound bound to G-quadruplex DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Molecular Anchoring of Duplex and Triplex DNA by Disubstituted Anthracene-9,10-diones: Calorimetric, UV Melting, and Competition Dialysis Studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

Inhibition of telomerase activity by PKC inhibitors in human nasopharyngeal cancer cells in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

9-Hydroxyellipticine inhibits telomerase activity in human pancreatic cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.1981

10.1517/13543784.8.12.1981

21 January 2018

Identifiers

DOI

1 reference

31 July 2017

1 reference

PubMed ID

11139836