(Q34121565)

2 July 2019

review article

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title

Beyond the cholinergic hypothesis: do current drugs work in Alzheimer's disease? (English)

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2 July 2019

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3

Giacomo Koch

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PubMed publication ID

31 July 2017

Alessandro Martorana

1

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Zaira Esposito

series ordinal

2

object named as

Zaira Esposito

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2 July 2019

language of work or name

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16 April 2010

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2 July 2019

CNS Neuroscience & Therapeutics

published in

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2 July 2019

volume

16

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2 July 2019

issue

4

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2 July 2019

page(s)

235-245

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2 July 2019

The clinical and cost-effectiveness of donepezil, rivastigmine, galantamine and memantine for Alzheimer's disease.

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https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00175.X

Effectiveness of Cholinesterase Inhibitors and Memantine for Treating Dementia: Evidence Review for a Clinical Practice Guideline

21 January 2018

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Release of [3H]-noradrenaline from rat hippocampal synaptosomes by nicotine: mediation by different nicotinic receptor subtypes from striatal [3H]-dopamine release

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00175.X

Noninvasive in vivo assessment of cholinergic cortical circuits in AD using transcranial magnetic stimulation

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00175.X

Different TMS patterns of intracortical inhibition in early onset Alzheimer dementia and frontotemporal dementia

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00175.X

Update on the use of memantine in Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1755-5949.2010.00175.X

Pathologic evaluation of the human suprachiasmatic nucleus in severe dementia

21 January 2018

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12 December 2020

The effects of donepezil in Alzheimer's disease - results from a multinational trial.

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12 December 2020

In vivo neurochemical effects of the acetylcholinesterase inhibitor ENA713 in rat hippocampus.

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12 December 2020

Evidence for a complex influence of nicotinic acetylcholine receptors on hippocampal serotonin release

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12 December 2020

Donepezil-induced REM sleep augmentation enhances memory performance in elderly, healthy persons.

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12 December 2020

Nicotinic receptor-mediated protection against beta-amyloid neurotoxicity

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12 December 2020

Nicotine and amyloid formation

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12 December 2020

Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease

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12 December 2020

Synaptic potentials mediated by alpha 7 nicotinic acetylcholine receptors in supraoptic nucleus.

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12 December 2020

Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins

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12 December 2020

Direct evidence that release-stimulating alpha7* nicotinic cholinergic receptors are localized on human and rat brain glutamatergic axon terminals

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12 December 2020

Chronic nicotine treatment reduces beta-amyloidosis in the brain of a mouse model of Alzheimer's disease (APPsw).

1 reference

12 December 2020

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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12 December 2020

The locus coeruleus–noradrenergic system: modulation of behavioral state and state-dependent cognitive processes

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12 December 2020

Cholinesterases: new roles in brain function and in Alzheimer's disease

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12 December 2020

Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro 04-6790.

1 reference

12 December 2020

Nicotinic enhancement of the noradrenergic inhibition of sleep-promoting neurons in the ventrolateral preoptic area.

1 reference

12 December 2020

Effects of donepezil treatment on rat nicotinic acetylcholine receptor levels in vivo and in vitro.

1 reference

12 December 2020

Effects of galantamine, a nicotinic allosteric potentiating ligand, on nicotine-induced catecholamine release in hippocampus and nucleus accumbens of rats

1 reference

12 December 2020

Slow-wave sleep, acetylcholine, and memory consolidation

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12 December 2020

Motor cortex hyperexcitability to transcranial magnetic stimulation in Alzheimer's disease

1 reference

12 December 2020

Nicotine reduces A beta in the brain and cerebral vessels of APPsw mice.

1 reference

12 December 2020

Long-Term Cholinesterase Inhibitor Therapy for Alzheimer's Disease: Practical Considerations for the Primary Care Physician

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12 December 2020

Metaanalysis of randomized trials of the efficacy and safety of donepezil, galantamine, and rivastigmine for the treatment of Alzheimer disease

1 reference

12 December 2020

Cholinergic drugs for Alzheimer's disease enhance in vitro dopamine release

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12 December 2020

The alpha7 nicotinic acetylcholine receptor-selective antagonist, methyllycaconitine, partially protects against beta-amyloid1-42 toxicity in primary neuron-enriched cultures

1 reference

12 December 2020

Signal transduction during amyloid-beta-peptide neurotoxicity: role in Alzheimer disease

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12 December 2020

Declarative memory consolidation: mechanisms acting during human sleep.

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12 December 2020

Effects of donepezil on Alzheimer's disease: the relationship between cognitive function and rapid eye movement sleep

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12 December 2020

Indicators of neuroprotection with galantamine

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12 December 2020

A preclinical view of cholinesterase inhibitors in neuroprotection: do they provide more than symptomatic benefits in Alzheimer's disease?

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12 December 2020

Cholinergic-serotonergic imbalance contributes to cognitive and behavioral symptoms in Alzheimer's disease.

1 reference

12 December 2020

Integrated treatment approach improves cognitive function in demented and clinically depressed patients

1 reference

12 December 2020

New insights into serotonin 5-HT4 receptors : a novel therapeutic target for Alzheimer's disease?

1 reference

12 December 2020

Presynaptic alpha7 and non-alpha7 nicotinic acetylcholine receptors modulate [3H]d-aspartate release from rat frontal cortex in vitro

1 reference

12 December 2020

Nicotinic and muscarinic subtypes in the human brain: changes with aging and dementia

1 reference

12 December 2020

Treating patients with moderate to severe Alzheimer's disease: implications of recent pharmacologic studies

1 reference

12 December 2020

Dopamine D5 receptor localization on cholinergic neurons of the rat forebrain and diencephalon: a potential neuroanatomical substrate involved in mediating dopaminergic influences on acetylcholine release

1 reference

12 December 2020

Indirect modulation by alpha7 nicotinic acetylcholine receptors of noradrenaline release in rat hippocampal slices: interaction with glutamate and GABA systems and effect of nicotine withdrawal.

1 reference

12 December 2020

A systematic review of the clinical effectiveness of donepezil, rivastigmine and galantamine on cognition, quality of life and adverse events in Alzheimer's disease

1 reference

12 December 2020

Circadian cholinergic rhythms: implications for cholinesterase inhibitor therapy

1 reference

12 December 2020

Cholinesterase inhibitors for Alzheimer's disease

1 reference

12 December 2020

The effect of donepezil on sleep and REM sleep EEG in patients with Alzheimer disease: a double-blind placebo-controlled study.

1 reference

12 December 2020

M1 receptors play a central role in modulating AD-like pathology in transgenic mice

1 reference

12 December 2020

Changes in cerebral neurotransmitters and metabolites induced by acute donepezil and memantine administrations: a microdialysis study

1 reference

12 December 2020

Galantamine enhances dopaminergic neurotransmission in vivo via allosteric potentiation of nicotinic acetylcholine receptors

1 reference

12 December 2020

Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade

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12 December 2020

Combined blockade of cholinergic receptors shifts the brain from stimulus encoding to memory consolidation.

1 reference

12 December 2020

Acetylcholinesterase inhibitors and sleep architecture in patients with Alzheimer's disease

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12 December 2020

Down-regulation of vesicular glutamate transporters precedes cell loss and pathology in Alzheimer's disease

1 reference

12 December 2020

A systematic review of assessment and treatment of moderate to severe Alzheimer's disease

1 reference

12 December 2020

Activation of 5-HT4 receptors inhibits secretion of beta-amyloid peptides and increases neuronal survival

1 reference

12 December 2020

Realistic expectations for treatment success in Alzheimer's disease

1 reference

12 December 2020

Imaging the role of dopamine in health and disease Parkinson's disease as a lesion model

1 reference

12 December 2020

The relationship between REM sleep and memory consolidation in old age and effects of cholinergic medication

1 reference

12 December 2020

Immunohistochemical localization of dopamine receptor subtypes (D1R-D5R) in Alzheimer's disease brain

1 reference

12 December 2020

Selective blockade of dopamine D(3) versus D(2) receptors enhances frontocortical cholinergic transmission and social memory in rats: a parallel neurochemical and behavioural analysis

1 reference

12 December 2020

Decoding NMDA receptor signaling: identification of genomic programs specifying neuronal survival and death

1 reference

12 December 2020

Functional outcomes of drug treatment in Alzheimer's disease: A systematic review and meta-analysis

1 reference

12 December 2020

5-HT4 receptor agonists increase sAPPalpha levels in the cortex and hippocampus of male C57BL/6j mice

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12 December 2020

The National Institute for Health and Clinical Excellence (NICE) and drug treatment for Alzheimer's disease

1 reference

12 December 2020

5-hydroxytryptamine 4 receptor activation of the extracellular signal-regulated kinase pathway depends on Src activation but not on G protein or beta-arrestin signaling.

1 reference

12 December 2020

Pathologically-activated therapeutics for neuroprotection: mechanism of NMDA receptor block by memantine and S-nitrosylation

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12 December 2020

NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders

1 reference

12 December 2020

Loss of VGLUT1 and VGLUT2 in the prefrontal cortex is correlated with cognitive decline in Alzheimer disease

1 reference

12 December 2020

Acute beta-amyloid administration disrupts the cholinergic control of dopamine release in the nucleus accumbens

1 reference

12 December 2020

MDMA induces EPSP-Spike potentiation in rat ventral hippocampus in vitro via serotonin and noradrenaline release and coactivation of 5-HT4 and beta1 receptors

1 reference

12 December 2020

Synthesis of specific bivalent probes that functionally interact with 5-HT(4) receptor dimers

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12 December 2020

Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system--too little activation is bad, too much is even worse

1 reference

12 December 2020

Prucalopride and donepezil act synergistically to reverse scopolamine-induced memory deficit in C57Bl/6j mice.

1 reference

12 December 2020

Alpha7 nicotinic receptor up-regulation in cholinergic basal forebrain neurons in Alzheimer disease.

1 reference

12 December 2020

Muscarinic acetylcholine receptors as CNS drug targets

1 reference

12 December 2020

Aromatic residues at position 55 of rat alpha7 nicotinic acetylcholine receptors are critical for maintaining rapid desensitization

1 reference

12 December 2020

Noradrenergic modulation of arousal

1 reference

12 December 2020

Memory formation, amnesia, improved memory and reversed amnesia: 5-HT role

1 reference

12 December 2020

Serotoninergic dorsal raphe neurons possess functional postsynaptic nicotinic acetylcholine receptors.

1 reference

12 December 2020

Functional consequences of locus coeruleus degeneration in Alzheimer's disease

1 reference

12 December 2020

L-dopa modulates motor cortex excitability in Alzheimer's disease patients

1 reference

12 December 2020

An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function

1 reference

12 December 2020

Functional convergence of dopaminergic and cholinergic input is critical for hippocampus-dependent working memory.

1 reference

12 December 2020

Efficacy and safety of donepezil, galantamine, and rivastigmine for the treatment of Alzheimer's disease: a systematic review and meta-analysis

1 reference

12 December 2020

Modulation of hippocampus-dependent learning and synaptic plasticity by nicotine

1 reference

12 December 2020

Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors.

1 reference

12 December 2020

Effects of cholinesterase inhibitors on rat nicotinic receptor levels in vivo and in vitro

1 reference

12 December 2020

Importance of circadian rhythmicity in the cholinergic treatment of Alzheimer's disease: focus on galantamine*.

1 reference

12 December 2020

Nicotinic receptor agonists and antagonists increase sAPPalpha secretion and decrease Abeta levels in vitro

1 reference

12 December 2020

Cholinergic modulation of the cerebral metabolic response to citalopram in Alzheimer's disease

1 reference

12 December 2020

Current treatments for sleep disturbances in individuals with dementia

1 reference

12 December 2020

Roles of nicotinic receptors in acetylcholinesterase inhibitor-induced neuroprotection and nicotinic receptor up-regulation

1 reference

12 December 2020

Cholinesterase inhibitors and beyond

1 reference

12 December 2020

Cortical alpha7 nicotinic acetylcholine receptor and beta-amyloid levels in early Alzheimer disease.

1 reference

12 December 2020

Nicotinic mechanisms influencing synaptic plasticity in the hippocampus

1 reference

12 December 2020

Pharmacological Treatment of Alzheimer's Disease: Is it Progressing Adequately?

1 reference

12 December 2020

Dopamine modulates cholinergic cortical excitability in Alzheimer's disease patients.

1 reference

12 December 2020

Efficacy of SSRIs on cognition of Alzheimer's disease patients treated with cholinesterase inhibitors.

1 reference

12 December 2020

DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease - a multicentre RCT

1 reference

12 December 2020

Alzheimer's disease amyloid beta-protein and synaptic function

1 reference

12 December 2020

Alpha7 neuronal nicotinic receptors: the missing link to understanding Alzheimer's etiopathology?

1 reference

12 December 2020

Persistent treatment with cholinesterase inhibitors and/or memantine slows clinical progression of Alzheimer disease

1 reference

12 December 2020

Rivastigmine transdermal system for the treatment of mild to moderate Alzheimer's disease

1 reference

12 December 2020

The cholinergic hypothesis of geriatric memory dysfunction

1 reference

12 December 2020

Second generation cholinesterase inhibitors: effect of (L)-huperzine-A on cortical biogenic amines

1 reference

12 December 2020

Coupling of muscarinic receptors to GTP proteins in postmortem human brain--alterations in Alzheimer's disease

1 reference

12 December 2020

The effect of the selective reversible acetylcholinesterase inhibitor E2020 on extracellular acetylcholine and biogenic amine levels in rat cortex.

1 reference

12 December 2020

Downregulation of muscarinic- and 5-HT1B-mediated modulation of [3H]acetylcholine release in hippocampal slices of rats with fimbria-fornix lesions and intrahippocampal grafts of septal origin

1 reference

12 December 2020

Acetylcholine: a neurotransmitter for learning and memory?

1 reference

12 December 2020

Nicotine inhibits amyloid formation by the beta-peptide.

1 reference

12 December 2020

Muscarinic M1 receptor agonists increase the secretion of the amyloid precursor protein ectodomain

1 reference

12 December 2020

Effects of the M1 agonist xanomeline on processing of human beta-amyloid precursor protein (FAD, Swedish mutant) transfected into Chinese hamster ovary-m1 cells.

1 reference

12 December 2020

Perspectives in the management of Alzheimer's disease: clinical profile of donepezil.

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12 December 2020

10.1111/J.1755-5949.2010.00175.X

Identifiers

DOI

1 reference

2 July 2019

PMC publication ID

6493875

1 reference

2 July 2019

PubMed publication ID

20560995

1 reference

2 July 2019