(Q34121655)

31 July 2017

Reevaluation of phosphorylation sites in the Parkinson disease-associated leucine-rich repeat kinase 2 (English)

1 reference

31 July 2017

1 reference

1 reference

4

Ted M Dawson

1 reference

31 July 2017

2

Darren J Moore

1 reference

31 July 2017

Xiaojie Li

1

1 reference

31 July 2017

Yulan Xiong

series ordinal

3

1 reference

31 July 2017

Valina L Dawson

series ordinal

5

1 reference

31 July 2017

language of work or name

English

0 references

publication date

1 July 2010

1 reference

Journal of Biological Chemistry

31 July 2017

1 reference

31 July 2017

285

1 reference

31 July 2017

29569-29576

1 reference

31 July 2017

38

1 reference

describes a project that uses

31 July 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2937988/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937988

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937988

CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937988

Leucine-rich repeat kinase 2 (LRRK2): a key player in the pathogenesis of Parkinson's disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937988

LRRK2 regulates synaptic vesicle endocytosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937988

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937988

Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937988

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937988

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937988

Localization of LRRK2 to membranous and vesicular structures in mammalian brain

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937988

The familial Parkinsonism gene LRRK2 regulates neurite process morphology

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937988

Kinase activity of mutant LRRK2 mediates neuronal toxicity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937988

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937988

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937988

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937988

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937988

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937988

Regulation of protein kinases; controlling activity through activation segment conformation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937988

LRRK2 G2019S and R1441G mutations associated with Parkinson's disease are common in the Basque Country, but relative prevalence is determined by ethnicity.

28 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.127639

The prevalence of the G2019S and R1441C/G/H mutations in LRRK2 in German patients with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.127639

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.127639

Genetic analysis for five LRRK2 mutations in a Sardinian parkinsonian population: importance of G2019S and R1441C mutations in sporadic Parkinson's disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.127639

Clinical features of LRRK2-associated Parkinson's disease in central Norway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.127639

Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.127639

Mechanistic insight into the dominant mode of the Parkinson's disease-associated G2019S LRRK2 mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.127639

GTPase activity plays a key role in the pathobiology of LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.127639

21 January 2018

Identifiers

DOI

10.1074/JBC.M110.127639

1 reference

31 July 2017

1 reference

31 July 2017

1 reference