(Q34122297)

31 July 2017

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title

The nuclear pore complex: bridging nuclear transport and gene regulation (English)

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31 July 2017

Caterina Strambio-De-Castillia

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1

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31 July 2017

Mario Niepel

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2

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31 July 2017

Michael P Rout

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3

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31 July 2017

1 July 2010

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Nature Reviews Molecular Cell Biology

31 July 2017

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31 July 2017

11

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31 July 2017

490-501

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31 July 2017

7

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https://scigraph.springernature.com/pub.10.1038/nrm2928

31 July 2017

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cites work

First and last ancestors: reconstructing evolution of the endomembrane system with ESCRTs, vesicle coat proteins, and nuclear pore complexes

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Transcriptional memory at the nuclear periphery

31 March 2020

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The nuclear envelope--a scaffold for silencing?

31 March 2020

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Evidence for a shared nuclear pore complex architecture that is conserved from the last common eukaryotic ancestor

31 March 2020

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31 March 2020

Peering through the Pore

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Structural analysis of the nuclear pore complex by integrated approaches.

31 March 2020

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Determining the architectures of macromolecular assemblies

31 March 2020

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The molecular architecture of the nuclear pore complex

31 March 2020

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The nuclear pore complex has entered the atomic age.

31 March 2020

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Modular self-assembly of a Y-shaped multiprotein complex from seven nucleoporins

31 March 2020

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Nuclear pores form de novo from both sides of the nuclear envelope

31 March 2020

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The nucleoporins Nup170p and Nup157p are essential for nuclear pore complex assembly

31 March 2020

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Components of coated vesicles and nuclear pore complexes share a common molecular architecture

31 March 2020

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Simple fold composition and modular architecture of the nuclear pore complex

31 March 2020

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The mechanisms of vesicle budding and fusion

31 March 2020

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Exporting RNA from the nucleus to the cytoplasm

31 March 2020

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Molecular mechanism of the nuclear protein import cycle

31 March 2020

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Protein import through the nuclear pore complex is a multistep process

31 March 2020

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The direction of transport through the nuclear pore can be inverted

31 March 2020

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Nucleocytoplasmic transport: Ran, beta and beyond

31 March 2020

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Flexible gates: dynamic topologies and functions for FG nucleoporins in nucleocytoplasmic transport

31 March 2020

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The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex

31 March 2020

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Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking

31 March 2020

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Rapid evolution exposes the boundaries of domain structure and function in natively unfolded FG nucleoporins

31 March 2020

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The yeast nuclear pore complex: composition, architecture, and transport mechanism

31 March 2020

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Proteomic analysis of the mammalian nuclear pore complex

31 March 2020

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Disorder in the nuclear pore complex: the FG repeat regions of nucleoporins are natively unfolded

31 March 2020

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Flexible phenylalanine-glycine nucleoporins as entropic barriers to nucleocytoplasmic transport

31 March 2020

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Natively unfolded nucleoporins gate protein diffusion across the nuclear pore complex.

31 March 2020

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Artificial nanopores that mimic the transport selectivity of the nuclear pore complex

31 March 2020

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Visualization of transport-related configurations of the nuclear pore transporter

31 March 2020

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Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins

31 March 2020

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Gradient of increasing affinity of importin beta for nucleoporins along the pathway of nuclear import

31 March 2020

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Virtual gating and nuclear transport: the hole picture

31 March 2020

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Translocation through the nuclear pore: Kaps pave the way.

31 March 2020

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Nanomechanical basis of selective gating by the nuclear pore complex.

31 March 2020

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The permeability barrier of nuclear pore complexes appears to operate via hydrophobic exclusion

31 March 2020

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FG-Rich Repeats of Nuclear Pore Proteins Form a Three-Dimensional Meshwork with Hydrogel-Like Properties

31 March 2020

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A Saturated FG-Repeat Hydrogel Can Reproduce the Permeability Properties of Nuclear Pore Complexes

31 March 2020

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Characterisation of the passive permeability barrier of nuclear pore complexes

31 March 2020

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Amyloid-like interactions within nucleoporin FG hydrogels

31 March 2020

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Transport into and out of the nucleus

31 March 2020

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Intramolecular cohesion of coils mediated by phenylalanine--glycine motifs in the natively unfolded domain of a nucleoporin

31 March 2020

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31 March 2020

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Simple kinetic relationships and nonspecific competition govern nuclear import rates in vivo.

31 March 2020

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Efficiency, selectivity, and robustness of nucleocytoplasmic transport

31 March 2020

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Nuclear Pore Complexes: “Press-Stud” Elements of Chromosomes in Pairing and Control

31 March 2020

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Gene gating: a hypothesis

31 March 2020

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A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export

31 March 2020

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Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p

31 March 2020

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Molecular basis for the functional interaction of dynein light chain with the nuclear-pore complex

31 March 2020

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mRNA nuclear export at a glance

31 March 2020

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Crosstalk between the actin cytoskeleton and Ran-mediated nuclear transport

31 March 2020

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The nuclear pore component Nup358 promotes transportin-dependent nuclear import.

31 March 2020

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Ratcheting mRNA out of the nucleus

31 March 2020

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Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region

31 March 2020

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SUMO-1 modification and its role in targeting the Ran GTPase-activating protein, RanGAP1, to the nuclear pore complex

31 March 2020

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In situ SUMOylation analysis reveals a modulatory role of RanBP2 in the nuclear rim and PML bodies

31 March 2020

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Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex

31 March 2020

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Viral interactions with the cytoskeleton: a hitchhiker's guide to the cell

31 March 2020

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A microtubule-facilitated nuclear import pathway for cancer regulatory proteins.

31 March 2020

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Highways for mRNA transport

31 March 2020

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The nucleoporin Nup358 associates with and regulates interphase microtubules

31 March 2020

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RANBP2 is an allosteric activator of the conventional kinesin-1 motor protein, KIF5B, in a minimal cell-free system

31 March 2020

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Toward a more complete 3-D structure of the nuclear pore complex

31 March 2020

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High-resolution field emission scanning electron microscope imaging of internal cell structures after Epon extraction from sections: a new approach to correlative ultrastructural and immunocytochemical studies

31 March 2020

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High resolution scanning electron microscopy of the nuclear envelope: demonstration of a new, regular, fibrous lattice attached to the baskets of the nucleoplasmic face of the nuclear pores

31 March 2020

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Calcium-mediated structural changes of native nuclear pore complexes monitored by time-lapse atomic force microscopy.

31 March 2020

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Snapshots of nuclear pore complexes in action captured by cryo-electron tomography

31 March 2020

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Yeast nuclear pore complexes have a cytoplasmic ring and internal filaments.

31 March 2020

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A look at messenger RNP moving through the nuclear pore

31 March 2020

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Nup153 affects entry of messenger and ribosomal ribonucleoproteins into the nuclear basket during export

31 March 2020

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Exclusion of mRNPs and ribosomal particles from a thin zone beneath the nuclear envelope revealed upon inhibition of transport.

31 March 2020

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Protein Tpr is required for establishing nuclear pore-associated zones of heterochromatin exclusion

31 March 2020

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Tpr, a large coiled coil protein whose amino terminus is involved in activation of oncogenic kinases, is localized to the cytoplasmic surface of the nuclear pore complex

31 March 2020

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The evolutionarily conserved single-copy gene for murine Tpr encodes one prevalent isoform in somatic cells and lacks paralogs in higher eukaryotes

31 March 2020

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Megator, an essential coiled-coil protein that localizes to the putative spindle matrix during mitosis in Drosophila.

31 March 2020

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Proteins connecting the nuclear pore complex with the nuclear interior

31 March 2020

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Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export

31 March 2020

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Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket

31 March 2020

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Identification of protein p270/Tpr as a constitutive component of the nuclear pore complex-attached intranuclear filaments

31 March 2020

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Amino acid substitutions of coiled-coil protein Tpr abrogate anchorage to the nuclear pore complex but not parallel, in-register homodimerization

31 March 2020

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Nuclear retention of unspliced mRNAs in yeast is mediated by perinuclear Mlp1.

31 March 2020

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Mlp-dependent anchorage and stabilization of a desumoylating enzyme is required to prevent clonal lethality

31 March 2020

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Developmentally induced changes in transcriptional program alter spatial organization across chromosomes

31 March 2020

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The nuclear pore complex-associated protein, Mlp2p, binds to the yeast spindle pole body and promotes its efficient assembly

31 March 2020

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Perinuclear Mlp proteins downregulate gene expression in response to a defect in mRNA export

31 March 2020

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A nuclear envelope protein linking nuclear pore basket assembly, SUMO protease regulation, and mRNA surveillance

31 March 2020

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Nucleoporins prevent DNA damage accumulation by modulating Ulp1-dependent sumoylation processes

31 March 2020

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NUCLEAR PORE ANCHOR, the Arabidopsis homolog of Tpr/Mlp1/Mlp2/megator, is involved in mRNA export and SUMO homeostasis and affects diverse aspects of plant development.

31 March 2020

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Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint

31 March 2020

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Mlp1 acts as a mitotic scaffold to spatially regulate spindle assembly checkpoint proteins in Aspergillus nidulans

31 March 2020

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Spatiotemporal control of mitosis by the conserved spindle matrix protein Megator

31 March 2020

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An endoribonuclease functionally linked to perinuclear mRNP quality control associates with the nuclear pore complexes

31 March 2020

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Gene loops function to maintain transcriptional memory through interaction with the nuclear pore complex

31 March 2020

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DNA zip codes control an ancient mechanism for gene targeting to the nuclear periphery

31 March 2020

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Nuclear pore proteins nup153 and megator define transcriptionally active regions in the Drosophila genome

31 March 2020

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mRNA export: an assembly line from genes to nuclear pores

31 March 2020

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HSF1-TPR interaction facilitates export of stress-induced HSP70 mRNA

31 March 2020

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Mechanisms of nuclear mRNA quality control

31 March 2020

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The nuclear envelope and transcriptional control.

31 March 2020

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Sus1, Sac3, and Thp1 mediate post-transcriptional tethering of active genes to the nuclear rim as well as to non-nascent mRNP.

31 March 2020

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Quality control of mRNP in the nucleus

31 March 2020

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The exosome: a multipurpose RNA-decay machine

31 March 2020

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Proteomic analysis identifies a new complex required for nuclear pre-mRNA retention and splicing

31 March 2020

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Comprehensive mapping of long-range interactions reveals folding principles of the human genome

31 March 2020

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Perinuclear localization of chromatin facilitates transcriptional silencing.

31 March 2020

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Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development

31 March 2020

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Gene regulation through nuclear organization.

31 March 2020

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The mobile nucleoporin Nup2p and chromatin-bound Prp20p function in endogenous NPC-mediated transcriptional control

31 March 2020

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Cotranscriptional recruitment to the mRNA export receptor Mex67p contributes to nuclear pore anchoring of activated genes

31 March 2020

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Nup-PI: the nucleopore-promoter interaction of genes in yeast.

31 March 2020

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Nuclear pore association confers optimal expression levels for an inducible yeast gene

31 March 2020

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H2A.Z-mediated localization of genes at the nuclear periphery confers epigenetic memory of previous transcriptional state

31 March 2020

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Chromatin boundaries in budding yeast: the nuclear pore connection

31 March 2020

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Gene recruitment of the activated INO1 locus to the nuclear membrane

31 March 2020

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SWI/SNF is required for transcriptional memory at the yeast GAL gene cluster

31 March 2020

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Dominant role for signal transduction in the transcriptional memory of yeast GAL genes

31 March 2020

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SAGA interacting factors confine sub-diffusion of transcribed genes to the nuclear envelope

31 March 2020

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SAGA and a novel Drosophila export complex anchor efficient transcription and mRNA export to NPC.

31 March 2020

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Actively transcribed GAL genes can be physically linked to the nuclear pore by the SAGA chromatin modifying complex

31 March 2020

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Yeast Ataxin-7 links histone deubiquitination with gene gating and mRNA export

31 March 2020

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THO/Sub2p functions to coordinate 3'-end processing with gene-nuclear pore association.

31 March 2020

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Sus1, Cdc31, and the Sac3 CID Region Form a Conserved Interaction Platform that Promotes Nuclear Pore Association and mRNA Export

31 March 2020

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Mutational uncoupling of the role of Sus1 in nuclear pore complex targeting of an mRNA export complex and histone H2B deubiquitination

31 March 2020

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Structural basis for the interaction between yeast Spt-Ada-Gcn5 acetyltransferase (SAGA) complex components Sgf11 and Sus1.

31 March 2020

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Localization of DNAase I-sensitive sequences to specific regions of interphase nuclei.

31 March 2020

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The locus control region is required for association of the murine beta-globin locus with engaged transcription factories during erythroid maturation

31 March 2020

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Braking the silence: how heterochromatic gene repression is stopped in its tracks.

31 March 2020

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Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes

31 March 2020

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Nucleoporins directly stimulate expression of developmental and cell-cycle genes inside the nucleoplasm

31 March 2020

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Telomere tethering at the nuclear periphery is essential for efficient DNA double strand break repair in subtelomeric region

31 March 2020

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A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization

31 March 2020

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Functional targeting of DNA damage to a nuclear pore-associated SUMO-dependent ubiquitin ligase

31 March 2020

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Stimulation of in vitro sumoylation by Slx5-Slx8: evidence for a functional interaction with the SUMO pathway

31 March 2020

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Opening the DNA repair toolbox: localization of DNA double strand breaks to the nuclear periphery.

31 March 2020

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The DNA damage response at eroded telomeres and tethering to the nuclear pore complex.

31 March 2020

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Controlling the efficiency of excision repair

31 March 2020

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Genome-wide analysis of factors affecting transcription elongation and DNA repair: a new role for PAF and Ccr4-not in transcription-coupled repair.

31 March 2020

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The molecular basis of chromatin dynamics during nucleotide excision repair

31 March 2020

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Sem1 is a functional component of the nuclear pore complex-associated messenger RNA export machinery

31 March 2020

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Nuclear pore complex biogenesis

31 March 2020

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Orchestrating nuclear envelope disassembly and reassembly during mitosis

31 March 2020

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The yeast nuclear pore complex functionally interacts with components of the spindle assembly checkpoint

31 March 2020

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Spindle checkpoint proteins and chromosome-microtubule attachment in budding yeast

31 March 2020

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Interactions between Mad1p and the nuclear transport machinery in the yeast Saccharomyces cerevisiae

31 March 2020

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The nuclear export factor Xpo1p targets Mad1p to kinetochores in yeast

31 March 2020

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In vivo dynamics of Drosophila nuclear envelope components

31 March 2020

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Nucleoporin translocated promoter region (Tpr) associates with dynein complex, preventing chromosome lagging formation during mitosis.

31 March 2020

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Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: a perspective from genetic studies in mice

31 March 2020

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Mechanisms of Receptor-Mediated Nuclear Import and Nuclear Export

31 March 2020

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SnapShot: nuclear transport.

31 March 2020

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Viral RNAs: lessons from the enemy

31 March 2020

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Mechanisms that regulate localization of a DNA double-strand break to the nuclear periphery

31 March 2020

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Yeast telomerase and the SUN domain protein Mps3 anchor telomeres and repress subtelomeric recombination

31 March 2020

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Mps3p is a novel component of the yeast spindle pole body that interacts with the yeast centrin homologue Cdc31p

31 March 2020

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SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice.

31 March 2020

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Life on the edge: telomeres and persistent DNA breaks converge at the nuclear periphery

31 March 2020

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Functional association of Sun1 with nuclear pore complexes

31 March 2020

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Role for perinuclear chromosome tethering in maintenance of genome stability.

31 March 2020

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Ufd2, a novel autoantigen in scleroderma, regulates sister chromatid separation

31 March 2020

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The inner nuclear membrane protein Src1 associates with subtelomeric genes and alters their regulated gene expression

31 March 2020

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The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instability

31 March 2020

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A new connection of mRNP biogenesis and export with transcription-coupled repair

31 March 2020

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Different physiological relevance of yeast THO/TREX subunits in gene expression and genome integrity

31 March 2020

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KASH-domain proteins and the cytoskeletal landscapes of the nuclear envelope

31 March 2020

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Messenger RNA export from the nucleus: a series of molecular wardrobe changes

31 March 2020

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Biogenesis of mRNPs: integrating different processes in the eukaryotic nucleus

31 March 2020

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Differential export requirements for shuttling serine/arginine-type mRNA-binding proteins

31 March 2020

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Regulation of mRNP dynamics along the export pathway

31 March 2020

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A Drosophila Tpr protein homolog is localized both in the extrachromosomal channel network and to nuclear pore complexes.

31 March 2020

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12 December 2020

Comparative genomics, evolution and origins of the nuclear envelope and nuclear pore complex

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12 December 2020

Minimal nuclear pore complexes define FG repeat domains essential for transport

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12 December 2020

Active nuclear pore complexes in Chironomus: visualization of transporter configurations related to mRNP export.

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12 December 2020

Peering through the pore: nuclear pore complex structure, assembly, and function

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12 December 2020

Transcription and double-strand breaks induce similar mitotic recombination events in Saccharomyces cerevisiae.

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12 December 2020

Identifiers

DOI

10.1038/NRM2928

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Dimensions Publication ID

31 July 2017

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