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T-helper type 2 cell-directed therapy for asthma
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
11150597
retrieved
31 July 2017
review article
1 reference
stated in
Europe PubMed Central
title
T-helper type 2 cell-directed therapy for asthma
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
11150597
retrieved
31 July 2017
main subject
asthma
0 references
author name string
Cohn L
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
11150597
retrieved
31 July 2017
Ray A
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
11150597
retrieved
31 July 2017
publication date
1 November 2000
1 reference
stated in
Europe PubMed Central
PubMed ID
11150597
retrieved
31 July 2017
published in
Pharmacology & Therapeutics
1 reference
stated in
Europe PubMed Central
PubMed ID
11150597
retrieved
31 July 2017
volume
88
1 reference
stated in
Europe PubMed Central
PubMed ID
11150597
retrieved
31 July 2017
issue
2
1 reference
stated in
Europe PubMed Central
PubMed ID
11150597
retrieved
31 July 2017
page(s)
187-196
1 reference
stated in
Europe PubMed Central
PubMed ID
11150597
retrieved
31 July 2017
cites work
Differences between IL-4R alpha-deficient and IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responses
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Identification of T lymphocytes, macrophages, and activated eosinophils in the bronchial mucosa in intrinsic asthma. Relationship to symptoms and bronchial responsiveness
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Interleukin-4 receptor in moderate atopic asthma. A phase I/II randomized, placebo-controlled trial.
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Interleukin 4 is localized to and released by human mast cells
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7 January 2021
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Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to
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Could asthma be worsened by stimulating the T-helper type 1 immune response?
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Cyclic AMP activates p38 mitogen-activated protein kinase in Th2 cells: phosphorylation of GATA-3 and stimulation of Th2 cytokine gene expression
1 reference
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Crossref
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7 January 2021
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Inhibition of IgE-dependent histamine release from human dispersed lung mast cells by anti-allergic drugs and salbutamol
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Antibody to interleukin-5 inhibits helminth-induced eosinophilia in mice
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7 January 2021
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Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production
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7 January 2021
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T helper 1 cells and interferon gamma regulate allergic airway inflammation and mucus production
1 reference
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Crossref
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7 January 2021
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Do allergens induce type-2 immune responses?
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Regulation of IgE production by beta 2-adrenoceptor agonists
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7 January 2021
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T lymphocyte activation in acute severe asthma
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T lymphocytes and eosinophils in the nasal mucosa and increases the number of cells expressing messenger RNA for interferon-gamma.
1 reference
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Crossref
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7 January 2021
based on heuristic
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Long-term clinical efficacy of grass-pollen immunotherapy
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7 January 2021
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Airway remodeling in asthma
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7 January 2021
based on heuristic
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Infection of mice with Mycobacterium bovis-Bacillus Calmette-Guérin (BCG) suppresses allergen-induced airway eosinophilia
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based on heuristic
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Regulation of IgE and cytokine production by cAMP: implications for extrinsic asthma
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7 January 2021
based on heuristic
inferred from DOI database lookup
Lymphokine-mediated regulation of the proliferative response of clones of T helper 1 and T helper 2 cells
1 reference
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Crossref
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7 January 2021
based on heuristic
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Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of eight weeks of treatment with salmeterol on bronchoalveolar lavage inflammatory indices in asthmatics
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Requirement for IL-13 independently of IL-4 in experimental asthma
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Vaccination with heat-killed Listeria as adjuvant reverses established allergen-induced airway hyperreactivity and inflammation: role of CD8+ T cells and IL-18
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Recombinant interleukin 12 cures mice infected with Leishmania major
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4.
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Aeroallergen-induced eosinophilic inflammation, lung damage, and airways hyperreactivity in mice can occur independently of IL-4 and allergen-specific immunoglobulins
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
A potential vaccine strategy for asthma and allied atopic diseases during early childhood.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The one-two of T helper cells: does interferon-gamma knock out the Th2 hypothesis for asthma?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interferon gamma regulates antigen-induced eosinophil recruitment into the mouse airways by inhibiting the infiltration of CD4+ T cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Disodium cromoglycate inhibits activation of human inflammatory cells in vitro.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Distinct functional phenotypes of cloned Ia-restricted helper T cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanisms and therapeutic applications of immune stimulatory cpG DNA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of sodium cromoglycate and nedocromil sodium on histamine secretion from human lung mast cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of protein tyrosine kinases in CD40/interleukin-4-mediated isotype switching to IgE
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cytokine mRNA profile and cell activation in bronchoalveolar lavage fluid from nonatopic patients with symptomatic asthma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
CD4+ T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Aerosolized recombinant interferon-gamma prevents antigen-induced eosinophil recruitment in mouse trachea
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Gene expression of the GATA-3 transcription factor is increased in atopic asthma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Late asthmatic responses
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
T cell response to Mycobacterium tuberculosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
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7 January 2021
based on heuristic
inferred from DOI database lookup
Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Th2 cells and GATA-3 in asthma: new insights into the regulation of airway inflammation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Antagonism of nuclear factor-kappa B functions by steroid hormone receptors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of CD4+ T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin-4, interleukin-5, and interferon-gamma cytokine gene expression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Relationships among numbers of bronchoalveolar lavage cells expressing messenger ribonucleic acid for cytokines, asthma symptoms, and airway methacholine responsiveness in atopic asthma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Measles and atopy in Guinea-Bissau
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The inverse association between tuberculin responses and atopic disorder.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of the Interleukin-5 Promoter by cAMP in Murine EL-4 Cells Requires the GATA-3 and CLE0 Elements
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Local expansion of allergen-specific CD30+Th2-type gamma delta T cells in bronchial asthma.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Developmental commitment to the Th2 lineage by extinction of IL-12 signaling.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Antiallergic drug cromolyn may inhibit histamine secretion by regulating phosphorylation of a mast cell protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transcription factor GATA-3 is required for development of the T-cell lineage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immunologic basis of antigen-induced airway hyperresponsiveness
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-13: central mediator of allergic asthma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of NK1.1+ T cells in a TH2 response and in immunoglobulin E production
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Beta 2-adrenergic receptors on eosinophils. Binding and functional studies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900091-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0163-7258(00)00091-7
1 reference
stated in
Europe PubMed Central
PubMed ID
11150597
retrieved
31 July 2017
PubMed ID
11150597
1 reference
stated in
Europe PubMed Central
PubMed ID
11150597
retrieved
31 July 2017
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