(Q34132787)

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Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2-mediated Jak2-STAT3 signaling pathway.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20732905%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2-mediated Jak2-STAT3 signaling pathway (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20732905%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

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based on heuristic

inferred from title

tumor angiogenesis

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based on heuristic

inferred from title

12

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11 February 2020

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Yanmin Dong

1

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11 February 2020

Binbin Lu

2

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11 February 2020

Xiaoli Zhang

3

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11 February 2020

Jing Zhang

4

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11 February 2020

Li Lai

5

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11 February 2020

Dali Li

6

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11 February 2020

Yuanyuan Wu

7

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11 February 2020

Yajuan Song

8

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11 February 2020

Jian Luo

9

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11 February 2020

Xiufeng Pang

10

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11 February 2020

Zhengfang Yi

11

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11 February 2020

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23 August 2010

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11 February 2020

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11 February 2020

31

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11 February 2020

12

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11 February 2020

2097-2104

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11 February 2020

Endogenous angiogenesis inhibitors

1 reference

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KSHV-GPCR and CXCR2 transforming capacity and angiogenic responses are mediated through a JAK2-STAT3-dependent pathway

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STAT proteins: From normal control of cellular events to tumorigenesis

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Nuclear translocation of phosphorylated STAT3 is essential for vascular endothelial growth factor-induced human dermal microvascular endothelial cell migration and tube formation

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21 January 2018

STAT3: a critical transcription activator in angiogenesis.

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21 January 2018

VEGF differentially activates STAT3 in microvascular endothelial cells

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21 January 2018

Activated STAT3 is a mediator and biomarker of VEGF endothelial activation

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21 January 2018

Cucurbitacins as kairomones for diabroticite beetles

1 reference

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21 January 2018

Cucurbitane-type compounds from Hemsleya carnosiflora antagonize ecdysteroid action in the Drosophila melanogaster BII cell line

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21 January 2018

Anticancer and antiinflammatory activities of cucurbitacins from Cucurbita andreana

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21 January 2018

Cucurbitacins and cucurbitane glycosides: structures and biological activities

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21 January 2018

Inhibitory effects of cucurbitane triterpenoids on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumor. II.

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Anticarcinogenic activity of natural sweeteners, cucurbitane glycosides, from Momordica grosvenori

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21 January 2018

Cucurbitacin B, a small molecule inhibitor of the Stat3 signaling pathway, enhances the chemosensitivity of laryngeal squamous cell carcinoma cells to cisplatin

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21 January 2018

Cucurbitacin E-induced disruption of the actin and vimentin cytoskeleton in prostate carcinoma cells.

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21 January 2018

Cucurbitacin E targets proliferating endothelia

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21 January 2018

Inhibitory effect of cucurbitacin E on pancreatic cancer cells growth via STAT3 signaling

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21 January 2018

Inhibitory effect of cucurbitacin E on the proliferation of ovarian cancer cells and its mechanism

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21 January 2018

Cucurbitacin E as a new inhibitor of cofilin phosphorylation in human leukemia U937 cells

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21 January 2018

Screening of biochemical modulator by tumor cell permeability of doxorubicin

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Gambogic acid inhibits angiogenesis and prostate tumor growth by suppressing vascular endothelial growth factor receptor 2 signaling.

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Protocol for the fast chromatin immunoprecipitation (ChIP) method

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Vasculogenesis and angiogenesis

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Disrupting tumour blood vessels

1 reference

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Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways

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Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma

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Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells

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