(Q34145273)

31 July 2017

title

PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX. (English)

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31 July 2017

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Giancarlo A Biagini

4

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David A. Fidock

object named as

David A Fidock

11

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Mathirut Mungthin

object named as

Mathirut Mungthin

2

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author name string

Patrick G Bray

1

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31 July 2017

Ian M Hastings

3

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31 July 2017

Dauda K Saidu

5

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31 July 2017

Viswanathan Lakshmanan

6

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31 July 2017

David J Johnson

7

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31 July 2017

Ruth H Hughes

8

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31 July 2017

Paul A Stocks

9

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31 July 2017

Paul M O'Neill

10

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31 July 2017

David C Warhurst

12

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31 July 2017

Stephen A Ward

13

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31 July 2017

language of work or name

English

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publication date

31 August 2006

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31 July 2017

published in

Molecular Microbiology

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31 July 2017

volume

62

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31 July 2017

issue

1

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31 July 2017

page(s)

238-251

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ClC chloride channels viewed through a transporter lens

31 July 2017

cites work

1 reference

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Evidence for a pfcrt-associated chloroquine efflux system in the human malarial parasite Plasmodium falciparum

5 July 2018

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A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance.

5 July 2018

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Dictyostelium discoideum expresses a malaria chloroquine resistance mechanism upon transfection with mutant, but not wild-type, Plasmodium falciparum transporter PfCRT.

5 July 2018

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Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance

5 July 2018

1 reference

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Evidence for a substrate specific and inhibitable drug efflux system in chloroquine resistant Plasmodium falciparum strains

5 July 2018

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Evidence for a Central Role for PfCRT in Conferring Plasmodium falciparum Resistance to Diverse Antimalarial Agents

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

The malaria parasite's chloroquine resistance transporter is a member of the drug/metabolite transporter superfamily

5 July 2018

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The principal chloroquine resistance protein of Plasmodium falciparum is a member of the drug/metabolite transporter superfamily

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

Trans stimulation provides evidence for a drug efflux carrier as the mechanism of chloroquine resistance in Plasmodium falciparum

5 July 2018

1 reference

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Heme binding contributes to antimalarial activity of bis-quaternary ammoniums

5 July 2018

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Amazing chloride channels: an overview

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

Lysosomes and drug resistance in malaria

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

Analysis of the antimalarial drug resistance protein Pfcrt expressed in yeast

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

The drug/metabolite transporter superfamily

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

The public health impact of chloroquine resistance in Africa

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

The structure of malaria pigment beta-haematin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

Characterisation of synthetic beta-haematin and effects of the antimalarial drugs quinidine, halofantrine, desbutylhalofantrine and mefloquine on its formation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

Cellular uptake of chloroquine is dependent on binding to ferriprotoporphyrin IX and is independent of NHE activity in Plasmodium falciparum

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

A common mechanism for blockade of heme polymerization by antimalarial quinolines

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

Uptake of an antiplasmodial protease inhibitor into Plasmodium falciparum-infected human erythrocytes via a parasite-induced pathway.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

Role for the plasmodium falciparum digestive vacuole in chloroquine resistance

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

Access to hematin: the basis of chloroquine resistance.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

A comparison and analysis of several ways to promote haematin (haem) polymerisation and an assessment of its initiation in vitro

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

Identification of a chloroquine importer in Plasmodium falciparum. Differences in import kinetics are genetically linked with the chloroquine-resistant phenotype

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

Physicochemical properties correlated with drug resistance and the reversal of drug resistance in Plasmodium falciparum

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

Ferriprotoporphyrin IX fulfills the criteria for identification as the chloroquine receptor of malaria parasites

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

The molecular mechanism of action of the proton ionophore FCCP (carbonylcyanide p-trifluoromethoxyphenylhydrazone).

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

Accumulation of14C-chloroquine byEntamoeba histolytica

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

Acidification of endocytic vesicles by an ATP-dependent proton pump

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

Lysosomes, pH and the Anti-malarial Action of Chloroquine

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

Susceptibility of human malaria parasites to chloroquine is pH dependent

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

Interaction of ferriprotoporphyrin IX with the antimalarials amodiaquine and halofantrine

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

Alkalinization of the food vacuole of malaria parasites by quinoline drugs and alkylamines is not correlated with their antimalarial activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum: a catabolic pathway initiated by a specific aspartic protease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

Simulation of kinetic data on the influx and efflux of chloroquine by erythrocytes infected with Plasmodium falciparum. Evidence for a drug-importer in chloroquine-sensitive strains

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

Inhibition by chloroquine of a novel haem polymerase enzyme activity in malaria trophozoites

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

Energy dependence of chloroquine accumulation and chloroquine efflux in Plasmodium falciparum

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

Rapid chloroquine efflux phenotype in both chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum. A correlation of chloroquine sensitivity with energy-dependent drug accumulation.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

Human malaria parasites in continuous culture

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation

5 July 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2006.05368.X

Identification and characterization of the new gene rhtA involved in threonine and homoserine efflux in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2006.05368.X

Entamoeba histolytica: correlation of assessment methods to measure erythrocyte digestion, and effect of cysteine proteinases inhibitors in HM-1:IMSS and HK-9:NIH strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2006.05368.X

Acidification of the malaria parasite's digestive vacuole by a H+-ATPase and a H+-pyrophosphatase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2006.05368.X

Activation of HIV-1 coreceptor (CXCR4) mediates myelosuppression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2006.05368.X

Partitioning of halofantrine hydrochloride between water, micellar solutions, and soybean oil: Effects on its apparent ionization constant.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2006.05368.X

Patterns of haemozoin accumulation in tissue

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2943415

10.1111/J.1365-2958.2006.05368.X

28 October 2018

Identifiers

DOI

1 reference

31 July 2017

1 reference

31 July 2017

1 reference