(Q34145529)

31 July 2017

title

Pharmacological validation of Trypanosoma brucei phosphodiesterases as novel drug targets (English)

1 reference

31 July 2017

0 references

1 reference

Harry P de Koning

1

0 references

author name string

Matthew K Gould

2

1 reference

31 July 2017

Geert Jan Sterk

3

1 reference

31 July 2017

Hermann Tenor

4

1 reference

31 July 2017

Stefan Kunz

5

1 reference

31 July 2017

Edith Luginbuehl

6

1 reference

31 July 2017

Thomas Seebeck

7

1 reference

31 July 2017

language of work or name

English

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publication date

30 January 2012

1 reference

Journal of Infectious Diseases

31 July 2017

published in

1 reference

31 July 2017

volume

206

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31 July 2017

issue

2

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31 July 2017

page(s)

229-237

1 reference

Phosphodiesterase inhibitors as a new generation of antiprotozoan drugs: exploiting the benefit of enzymes that are highly conserved between host and parasite

31 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379837

State of the art in African trypanosome drug discovery

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379837

Design, synthesis, and structure-activity relationship of Trypanosoma brucei leucyl-tRNA synthetase inhibitors as antitrypanosomal agents

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379837

The N Terminus of Phosphodiesterase TbrPDEB1 of Trypanosoma brucei Contains the Signal for Integration into the Flagellar Skeleton

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379837

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379837

Crystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379837

Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379837

The deep roots of eukaryotes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379837

Genetic variants of the TbAT1 adenosine transporter from African trypanosomes in relapse infections following melarsoprol therapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379837

Drug resistance in Trypanosoma brucei spp., the causative agents of sleeping sickness in man and nagana in cattle

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379837

cAMP signalling in Trypanosoma brucei

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379837

Characterization of TbPDE2A, a novel cyclic nucleotide-specific phosphodiesterase from the protozoan parasite Trypanosoma brucei

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379837

Separation of Trypanosomes from the Blood of Infected Rats and Mice by Anion-exchangers

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379837

Identification, purification and properties of clone-specific glycoprotein antigens constituting the surface coat ofTrypanosoma brucei

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379837

Human African trypanosomiasis

5 July 2018

2 references

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR857

21 January 2018

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379837

Cyclic nucleotide specific phosphodiesterases of the kinetoplastida: a unified nomenclature.

9 December 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR857

The Trypanosoma brucei cAMP phosphodiesterases TbrPDEB1 and TbrPDEB2: flagellar enzymes that are essential for parasite virulence

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR857

Loss of the high-affinity pentamidine transporter is responsible for high levels of cross-resistance between arsenical and diamidine drugs in African trypanosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR857

A novel cultivation technique for long-term maintenance of bloodstream form trypanosomes in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR857

Propidium iodide-based methods for monitoring drug action in the kinetoplastidae: comparison with the Alamar Blue assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR857

Novel selective PDE4 inhibitors. 2. Synthesis and structure-activity relationships of 4-aryl-substituted cis-tetra- and cis-hexahydrophthalazinones

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR857

Ever-increasing complexities of diamidine and arsenical crossresistance in African trypanosomes

21 January 2018

2 references

https://api.crossref.org/works/10.1093%2FINFDIS%2FJIR857

21 January 2018

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379837

Assay of cyclic nucleotide phosphodiesterases with radioactive substrates

9 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22291195

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

An improved assay of cyclic 3',5'-nucleotide phosphodiesterases with QAE-Sephadex columns

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22291195

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/INFDIS/JIR857

1 reference

31 July 2017

1 reference

31 July 2017

1 reference