(Q34145570)

31 July 2017

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title

Structural aspects of protein kinase control-role of conformational flexibility (English)

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31 July 2017

Richard A Engh

1

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31 July 2017

Dirk Bossemeyer

series ordinal

2

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31 July 2017

publication date

1 February 2002

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Pharmacology & Therapeutics

31 July 2017

published in

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31 July 2017

volume

93

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31 July 2017

issue

2-3

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31 July 2017

page(s)

99-111

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Energetic limits of phosphotransfer in the catalytic subunit of cAMP-dependent protein kinase as measured by viscosity experiments

31 July 2017

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Specificity and mechanism of action of some commonly used protein kinase inhibitors

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Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors

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Crystal structure of cyclin-dependent kinase 2

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The protein kinase activity modulation sites: mechanisms for cellular regulation - targets for therapeutic intervention

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Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity

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Protein kinases as targets for anticancer agents: from inhibitors to useful drugs

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A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase

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7 January 2021

Structural basis for the autoinhibition of calcium/calmodulin-dependent protein kinase I

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Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

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CK2: a protein kinase in need of control.

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Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket

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7 January 2021

Physiological inhibitors of the catalytic subunit of cAMP-dependent protein kinase: effect of magnesium-ATP on protein-protein interactions

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Insights into autoregulation from the crystal structure of twitchin kinase

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Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

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Crystal structure of the tyrosine kinase domain of the human insulin receptor

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Determinants of ligand binding to cAMP-dependent protein kinase.

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7 January 2021

Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12

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7 January 2021

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

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7 January 2021

The Eleventh Datta Lecture. The structural basis for substrate recognition and control by protein kinases

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Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

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7 January 2021

Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine

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Initial sequencing and analysis of the human genome

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Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2

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7 January 2021

Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch

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7 January 2021

Identification of a partially rate-determining step in the catalytic mechanism of cAMP-dependent protein kinase: a transient kinetic study using stopped-flow fluorescence spectroscopy

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7 January 2021

Three-dimensional structure of mammalian casein kinase I: molecular basis for phosphate recognition

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7 January 2021

Structural basis for activation of the titin kinase domain during myofibrillogenesis

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7 January 2021

Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent

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7 January 2021

Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism

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7 January 2021

Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors

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Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain.

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7 January 2021

Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase

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7 January 2021

Crystal structure of the catalytic subunit of protein kinase CK2 from Zea mays at 2.1 A resolution.

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7 January 2021

GTP plus water mimic ATP in the active site of protein kinase CK2

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7 January 2021

Two structures of the catalytic domain of phosphorylase kinase: an active protein kinase complexed with substrate analogue and product

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7 January 2021

Staurosporine-induced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential

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7 January 2021

Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex

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7 January 2021

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7 January 2021

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7 January 2021

Biochemical evidence for the interaction of regulatory subunit of cAMP-dependent protein kinase with IDA (Inter-DFG-APE) region of catalytic subunit

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7 January 2021

Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor

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7 January 2021

Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

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7 January 2021

An ATP-linked structural change in protein kinase A precedes phosphoryl transfer under physiological magnesium concentrations

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7 January 2021

Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail

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7 January 2021

Crystal structure of the Src family tyrosine kinase Hck

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7 January 2021

Structural basis of inhibitor selectivity in MAP kinases

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7 January 2021

The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions

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7 January 2021

Crystal structure of p38 mitogen-activated protein kinase

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7 January 2021

Computational analysis of PKA-balanol interactions

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7 January 2021

Crystal structure of JNK3: a kinase implicated in neuronal apoptosis

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7 January 2021

Crystal structure of casein kinase-1, a phosphate-directed protein kinase

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7 January 2021

Structural basis for selectivity of the isoquinoline sulfonamide family of protein kinase inhibitors

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7 January 2021

Three-dimensional structure of the tyrosine kinase c-Src

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7 January 2021

Crystal structures of c-Src reveal features of its autoinhibitory mechanism

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7 January 2021

Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

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7 January 2021

Atomic structure of the MAP kinase ERK2 at 2.3 A resolution

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7 January 2021

Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor

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7 January 2021

Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors

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7 January 2021

10.1016/S0163-7258(02)00180-8

Identifiers

DOI

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31 July 2017

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