(Q34155281)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20675369%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

title

Metabolomic profiling reveals biochemical pathways and biomarkers associated with pathogenesis in cystic fibrosis cells (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20675369%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

0 references

0 references

metabolomic profiling

1 reference

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20675369%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

author name string

Diana R Wetmore

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20675369%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Elizabeth Joseloff

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20675369%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Joseph Pilewski

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20675369%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Douglas P Lee

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20675369%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Kay A Lawton

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20675369%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Michael V Milburn

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20675369%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

John A Ryals

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20675369%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Lining Guo

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20675369%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

language of work or name

English

0 references

publication date

30 July 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20675369%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

9 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20675369%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

volume

285

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20675369%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

issue

40

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20675369%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

page(s)

30516-30522

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20675369%20AND%20SRC:MED&resulttype=core&format=json

Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770

9 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

Cystic fibrosis pulmonary guidelines: treatment of pulmonary exacerbations

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

A phase II study on safety and efficacy of high-dose N-acetylcysteine in patients with cystic fibrosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

Novel human bronchial epithelial cell lines for cystic fibrosis research.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

Evidence-based practice recommendations for nutrition-related management of children and adults with cystic fibrosis and pancreatic insufficiency: results of a systematic review

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

Analysis of the adult human plasma metabolome

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

Spatiotemporal coupling of cAMP transporter to CFTR chloride channel function in the gut epithelia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

Mechanisms and significance of cell volume regulation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

Coordinated release of nucleotides and mucin from human airway epithelial Calu-3 cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

Adenosine regulation of alveolar fluid clearance

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

Monitoring the health to disease continuum with global metabolic profiling and systems biology

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

Activation of chloride transport in CF airway epithelial cell lines and primary CF nasal epithelial cells by S-nitrosoglutathione.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

S-nitrosylating agents: a novel class of compounds that increase cystic fibrosis transmembrane conductance regulator expression and maturation in epithelial cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

High-dose oral N-acetylcysteine, a glutathione prodrug, modulates inflammation in cystic fibrosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

The short apical membrane half-life of rescued {Delta}F508-cystic fibrosis transmembrane conductance regulator (CFTR) results from accelerated endocytosis of {Delta}F508-CFTR in polarized human airway epithelial cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

Cystic fibrosis since 1938.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

Occurrence of hypermutable Pseudomonas aeruginosa in cystic fibrosis patients is associated with the oxidative stress caused by chronic lung inflammation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

New insights into the pathogenesis of cystic fibrosis: pivotal role of glutathione system dysfunction and implications for therapy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

A pilot study of the effect of inhaled buffered reduced glutathione on the clinical status of patients with cystic fibrosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

Role for cystic fibrosis transmembrane conductance regulator protein in a glutathione response to bronchopulmonary pseudomonas infection

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

Statistical significance for genomewide studies

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

Acute effects of aerosolized S-nitrosoglutathione in cystic fibrosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

Rethinking cystic fibrosis pathology: the critical role of abnormal reduced glutathione (GSH) transport caused by CFTR mutation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

Abnormal glutathione transport in cystic fibrosis airway epithelia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

Structural basis for specificity and potency of xanthine derivatives as activators of the CFTR chloride channel.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

Culture and transformation of human airway epithelial cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

CFTR and outward rectifying chloride channels are distinct proteins with a regulatory relationship

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

Energy expenditure and genotype of children with cystic fibrosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

Chloride Conductance Expressed by ΔF508 and Other Mutant CFTRs In Xenopus Oocytes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

New insights into cystic fibrosis: molecular switches that regulate CFTR

28 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.140806

Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.140806

Metabolomics for early detection of drug-induced kidney injury: review of the current status

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.140806

Development and analysis of recombinant adenoviruses for gene therapy of cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.140806

Untargeted metabolomic profiling as an evaluative tool of fenofibrate-induced toxicology in Fischer 344 male rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.140806

Adenosine receptors, cystic fibrosis, and airway hydration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.140806

Extracellular purines are biomarkers of neutrophilic airway inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.140806

Mass spectrometric analysis of biomarkers and dilution markers in exhaled breath condensate reveals elevated purines in asthma and cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.140806

Organic solutes rescue the functional defect in delta F508 cystic fibrosis transmembrane conductance regulator.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.140806

Glutathione dysregulation and the etiology and progression of human diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.140806

Improvement in clinical markers in CF patients using a reduced glutathione regimen: an uncontrolled, observational study

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.140806

Kynurenine and its metabolites--kynurenic acid and anthranilic acid are associated with soluble endothelial adhesion molecules and oxidative status in patients with chronic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.140806

Well-differentiated human airway epithelial cell cultures.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945545

Systemic deficiency of glutathione in cystic fibrosis

28 October 2018

1 reference

12 December 2020

Ion transport across the normal and CF neonatal murine intestine

1 reference

12 December 2020

Molecular basis of formaldehyde detoxification. Characterization of two S-formylglutathione hydrolases from Escherichia coli, FrmB and YeiG

1 reference

12 December 2020

Decreased levels of nitrosothiols in the lower airways of patients with cystic fibrosis and normal pulmonary function

1 reference

12 December 2020

Pharmacological modulation of ion transport across wild-type and DeltaF508 CFTR-expressing human bronchial epithelia

1 reference

12 December 2020

Properties of CFTR activated by the xanthine derivative X-33 in human airway Calu-3 cells

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.140806

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20675369%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20675369%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference