(Q34157250)

31 July 2017

1 reference

title

Hepatitis B virus x protein in the pathogenesis of hepatitis B virus-induced hepatocellular carcinoma (English)

1 reference

31 July 2017

Hepatitis B virus x protein in the pathogenesis of hepatitis B virus‐induced hepatocellular carcinoma (English)

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

21 November 2024

1 reference

0 references

1 reference

Michael C. Kew

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21199526

21 November 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21199526

21 November 2024

publication date

1 January 2011

1 reference

31 July 2017

January 2011

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21199526

full work available at URL

21 November 2024

https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1440-1746.2010.06546.x

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21199526

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1440-1746.2010.06546.x

21 November 2024

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1440-1746.2010.06546.x

21 November 2024

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Journal of Gastroenterology and Hepatology

21 November 2024

published in

1 reference

31 July 2017

volume

26 Suppl 1

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31 July 2017

page(s)

144-152

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Epidemiology of chronic hepatitis B virus infection, hepatocellular carcinoma, and hepatitis B virus-induced hepatocellular carcinoma

31 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2010.06546.X

Aberrant Promoter Methylation Profiles of Tumor Suppressor Genes in Hepatocellular Carcinoma

21 January 2018

1 reference

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Epigenetic silence of ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region- containing protein 1 (ASPP1) and ASPP2 genes promotes tumor growth in hepatitis B virus-positive hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2010.06546.X

DNA ends: maintenance of chromosome termini versus repair of double strand breaks

21 January 2018

1 reference

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Upregulation of human telomerase reverse transcriptase mRNA expression by in vitro transfection of hepatitis B virus X gene into human hepatocarcinoma and cholangiocarcinoma cells

21 January 2018

1 reference

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A mutant of hepatitis B virus X protein (HBxDelta127) promotes cell growth through a positive feedback loop involving 5-lipoxygenase and fatty acid synthase

21 January 2018

1 reference

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Lack of colocalization of HBxAg and insulin like growth factor II in the livers of patients with chronic hepatitis B, cirrhosis and hepatocellular carcinoma

21 January 2018

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Molecular events in the pathogenesis of hepadnavirus-associated hepatocellular carcinoma

21 January 2018

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Selective accumulation of the X transcript of hepatitis B virus in patients negative for hepatitis B surface antigen with hepatocellular carcinoma

21 November 2024

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Hepatitis B virus X protein: a multifunctional viral regulator

21 November 2024

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Common evolutionary origin of hepatitis B virus and retroviruses

21 November 2024

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Hepatitis B virus X antigen in the pathogenesis of chronic infections and the development of hepatocellular carcinoma

21 November 2024

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Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis

21 November 2024

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X protein of hepatitis B virus modulates cytokine and growth factor related signal transduction pathways during the course of viral infections and hepatocarcinogenesis

21 November 2024

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In vitro tumorigenicity of hepatitis B virus DNA and HBx protein

21 November 2024

10

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Activated ras oncogene collaborates with HBx gene of hepatitis B virus to transform cells by suppressing HBx-mediated apoptosis

21 November 2024

11

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Integration of region X of hepatitis B virus genome in human primary hepatocellular carcinomas propagated in nude mice

21 November 2024

12

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

HBx gene of hepatitis B virus induces liver cancer in transgenic mice

21 November 2024

13

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virus X gene

21 November 2024

14

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Knockdown of HBx by RNAi inhibits proliferation and enhances chemotherapy-induced apoptosis in hepatocellular carcinoma cells

21 November 2024

15

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Gene silencing in cancer in association with promoter hypermethylation

21 November 2024

16

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https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Structure and function of eukaryotic DNA methyltransferases

21 November 2024

17

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https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Hepatitis B virus X protein represses E-cadherin expression via activation of DNA methyltransferase 1.

21 November 2024

19

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https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Downregulation of E-cadherin by hepatitis B virus X antigen in hepatocellullar carcinoma

21 November 2024

20

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Expression of DNA methyltransferase 1 is activated by hepatitis B virus X protein via a regulatory circuit involving the p16INK4a-cyclin D1-CDK 4/6-pRb-E2F1 pathway

21 November 2024

21

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Association of p16INK4A hypermethylation with hepatitis B virus X protein expression in the early stage of HBV-associated hepatocarcinogenesis

21 November 2024

22

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Hepatitis B virus X protein induces hypermethylation of p16(INK4A) promoter via DNA methyltransferases in the early stage of HBV-associated hepatocarcinogenesis

21 November 2024

23

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Expression of DNA methyltransferase 1 is activated by hepatitis B virus X protein via a regulatory circuit involving the p16INK4a-cyclin D1-CDK 4/6-pRb-E2F1 pathway

21 November 2024

24

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein

21 November 2024

25

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Epigenetic modification induced by hepatitis B virus X protein via interaction with de novo DNA methyltransferase DNMT3A.

21 November 2024

26

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

ASPP proteins specifically stimulate the apoptotic function of p53

21 November 2024

27

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Hepatitis B virus X protein overcomes the growth-inhibitory potential of retinoic acid by downregulating retinoic acid receptor-beta2 expression via DNA methylation

21 November 2024

29

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

HBx genotype D represses GSTP1 expression and increases the oxidative level and apoptosis in HepG2 cells

21 November 2024

30

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Mechanisms and Functions of Cell Death

21 November 2024

31

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https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Life, death, and the pursuit of apoptosis.

21 November 2024

32

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Putative role of hepatitis B virus X protein in hepatocarcinogenesis: effects on apoptosis, DNA repair, mitogen-activated protein kinase and JAK/STAT pathways

21 November 2024

33

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Progressive changes in hepatoma cells stably transfected with hepatitis B virus X gene

21 November 2024

34

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Functional inactivation but not structural mutation of p53 causes liver cancer.

21 November 2024

38

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3

21 November 2024

39

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

The hepatitis B virus-X protein activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade

21 November 2024

40

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

COX-2 mediates hepatitis B virus X protein abrogation of p53-induced apoptosis

21 November 2024

41

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Hepatitis B virus X protein prevents apoptosis of hepatocellular carcinoma cells by upregulating SATB1 and HURP expression

21 November 2024

42

1 reference

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p53-independent apoptotic effects of the hepatitis B virus HBx protein in vivo and in vitro

21 November 2024

43

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

X-gene Product of Hepatitis B Virus Induces Apoptosis in Liver Cells

21 November 2024

44

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Hepatitis B virus X protein induces apoptosis in hepatoma cells through inhibiting Bcl-xL expression

21 November 2024

45

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor α

21 November 2024

46

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Hepatitis B virus X protein via the p38MAPK pathway induces E2F1 release and ATR kinase activation mediating p53 apoptosis

21 November 2024

48

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Knock-down of hepatitis B virus X protein reduces the tumorigenicity of hepatocellular carcinoma cells

21 November 2024

49

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Blockade of TRAIL pathway ameliorates HBV-induced hepatocyte apoptosis in an acute hepatitis model

21 November 2024

50

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Structure and function of telomeres

21 November 2024

52

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Growth, telomere dynamics and successful and unsuccessful human aging

21 November 2024

54

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity

21 November 2024

55

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Telomere length variation and maintenance in hepatocarcinogenesis.

21 November 2024

57

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Effects of hepatitis B virus X protein on human telomerase reverse transcriptase expression and activity in hepatoma cells.

21 November 2024

59

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Telomerase and c-myc expression in hepatocellular carcinomas

21 November 2024

60

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

X protein of hepatitis B virus functions as a transcriptional corepressor on the human telomerase promoter

21 November 2024

61

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Phenylethanolamine N-methyltransferase gene expression. Sp1 and MAZ potential for tissue-specific expression

21 November 2024

62

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Telomerase activity, telomere length and human telomerase reverse transcriptase expression in hepatocellular carcinoma is independent of hepatitis virus status

21 November 2024

64

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Conservation of eukaryotic DNA repair mechanisms.

21 November 2024

65

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Nucleotide Excision Repair in Mammalian Cells

21 November 2024

66

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

p53 deficiency in liver reduces local control of survival and proliferation, but does not affect apoptosis after DNA damage

21 November 2024

69

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Hepatitis B virus X protein interferes with cellular DNA repair.

21 November 2024

70

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Hepatitis B virus X protein interacts with a probable cellular DNA repair protein

21 November 2024

71

1 reference

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Hepatitis B virus X-protein binds damaged DNA and sensitizes liver cells to ultraviolet irradiation

21 November 2024

72

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Hepatitis B virus transactivator protein, HBx, associates with the components of TFIIH and stimulates the DNA helicase activity of TFIIH

21 November 2024

73

1 reference

https://api.crossref.org/works/10.1111/J.1440-1746.2010.06546.X

Downregulation of DNA excision repair by the hepatitis B virus-x protein occurs in p53-proficient and p53-deficient cells

21 November 2024

74

1 reference

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21 November 2024

p53: puzzle and paradigm

75

1 reference

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Hepatitis B virus HBx protein deregulates cell cycle checkpoint controls

21 November 2024

76

1 reference

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The human hepatitis B virus transactivator X gene product regulates Sp1 mediated transcription of an insulin-like growth factor II promoter 4

21 November 2024

77

1 reference

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Altered DNA mutation spectrum in aflatoxin b1-treated transgenic mice that express the hepatitis B virus x protein

21 November 2024

78

1 reference

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Hepatitis B virus X mutants, present in hepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx.

21 November 2024

80

1 reference

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COOH-terminal truncated HBV X protein plays key role in hepatocarcinogenesis

21 November 2024

81

1 reference

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Expression of mutated hepatitis B virus X genes in human hepatocellular carcinomas

21 November 2024

82

1 reference

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Characterization of HBV integrants in 14 hepatocellular carcinomas: association of truncated X gene and hepatocellular carcinogenesis.

21 November 2024

83

1 reference

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A truncated mutant (residues 58-140) of the hepatitis B virus X protein retains transactivation function

21 November 2024

85

1 reference

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Mutations in the C-terminus of the X protein of hepatitis B virus regulate Wnt-5a expression in hepatoma Huh7 cells: cDNA microarray and proteomic analyses

21 November 2024

87

1 reference

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Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus

21 November 2024

88

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beta-Catenin mutation and overexpression in hepatocellular carcinoma: clinicopathologic and prognostic significance.

21 November 2024

89

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Expression of insulin-like growth factor II in hepatitis B, cirrhosis and hepatocellular carcinoma: its relationship with hepatitis B virus antigen expression

21 November 2024

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Activation of the IGF-II gene by HBV-X protein requires PKC and p44/p42 map kinase signalings

21 November 2024

96

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Mutational hot spot in the p53 gene in human hepatocellular carcinomas

21 November 2024

97

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Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa

21 November 2024

98

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The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway

21 November 2024

99

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Activation of the insulin-like growth factor II transcription by aflatoxin B1 induced p53 mutant 249 is caused by activation of transcription complexes; implications for a gain-of-function during the formation of hepatocellular carcinoma

21 November 2024

100

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21 November 2024

Identifiers

1 reference

31 July 2017

1 reference