(Q34157339)

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TET2 mutations are associated with specific 5-methylcytosine and 5-hydroxymethylcytosine profiles in patients with chronic myelomonocytic leukemia

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Europe PubMed Central

PubMed publication ID

31 July 2017

TET2 mutations are associated with specific 5-methylcytosine and 5-hydroxymethylcytosine profiles in patients with chronic myelomonocytic leukemia (English)

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Europe PubMed Central

PubMed publication ID

31 July 2017

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17

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Xabier Agirre

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Marta Fernandez-Mercado

object named as

Marta Fernandez-Mercado

6

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object named as

Eric Delabesse

5

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José I Martín-Subero

object named as

José Ignacio Martín-Subero

3

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Jacqueline Boultwood

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Jacqueline Boultwood

11

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Felipe Prósper

16

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7

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Leire Garate

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31 July 2017

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Cristina Pérez

1

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Europe PubMed Central

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31 July 2017

Nicolas Martínez-Calle

2

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31 July 2017

Victor Segura

4

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31 July 2017

Sara Alvarez

8

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31 July 2017

José Rifon

9

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31 July 2017

Sara Varea

10

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31 July 2017

James S Wainscoat

12

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31 July 2017

Juan Cruz Cigudosa

13

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31 July 2017

María José Calasanz

14

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31 July 2017

Nicholas C P Cross

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31 July 2017

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publication date

6 February 2012

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31 July 2017

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Europe PubMed Central

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31 July 2017

7

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31 July 2017

2

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31 July 2017

e31605

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Europe PubMed Central

PubMed publication ID

31 July 2017

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Creative Commons Attribution 4.0 International

6 February 2012

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April 2022 Public Data File from Crossref

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Europe PubMed Central

22 June 2022

https://europepmc.org/article/PMC/3273467

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inferred from PubMed Central ID database lookup

Genome-wide DNA methylation profiling using Infinium® assay

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

Frequent and simultaneous epigenetic inactivation of TP53 pathway genes in acute lymphoblastic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

Cytogenetic risk stratification in chronic myelomonocytic leukemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

Lyn- and PLC-beta3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemia-like disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

Phase 2 study of romiplostim in patients with low- or intermediate-risk myelodysplastic syndrome receiving azacitidine therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

New insights into the biology and origin of mature aggressive B-cell lymphomas by combined epigenomic, genomic, and transcriptional profiling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

Aberrant DNA methylation is a dominant mechanism in MDS progression to AML.

1 reference

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5 July 2018

An integrated genomic analysis of human glioblastoma multiforme

1 reference

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5 July 2018

c-Jun N-terminal kinase activation failure is a new mechanism of anthracycline resistance in acute myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

Induction of hypomethylation and molecular response after decitabine therapy in patients with chronic myelomonocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

Chronic neutrophilic leukemia and chronic myelomonocytic leukemia: WHO defined

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

Linear models and empirical bayes methods for assessing differential expression in microarray experiments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

Control of developmental regulators by Polycomb in human embryonic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

Reliability and reproducibility issues in DNA microarray measurements

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

Analysis of microarray data using Z score transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

Genesis: cluster analysis of microarray data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

5 July 2018

Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0031605

21 January 2018

Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0031605

21 January 2018

TET1 is a DNA-binding protein that modulates DNA methylation and gene transcription via hydroxylation of 5-methylcytosine

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0031605

21 January 2018

Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0031605

21 January 2018

Valproic acid at therapeutic plasma levels may increase 5-azacytidine efficacy in higher risk myelodysplastic syndromes.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0031605

21 January 2018

Aberrant methylation and impaired expression of the p15(INK4b) cell cycle regulatory gene in chronic myelomonocytic leukemia (CMML).

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0031605

21 January 2018

DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0031605

21 January 2018

JAKing up hematopoietic proliferation

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0031605

21 January 2018

Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0031605

21 January 2018

JNK and ERK mitogen-activated protein kinases mediate THDA-induced apoptosis in K562 cells

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0031605

21 January 2018

Activity of azacitidine in chronic myelomonocytic leukemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

28 October 2018

Activating FLT3 mutations are detectable in chronic and blast phase of chronic myeloproliferative disorders other than chronic myeloid leukemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3273467

28 October 2018

Next-Generation Sequencing Technology Reveals a Characteristic Pattern of Molecular Mutations in 72.8% of Chronic Myelomonocytic Leukemia by Detecting Frequent Alterations in TET2, CBL, RAS, and RUNX1

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0031605

21 January 2018

Molecular profiling of chronic myelomonocytic leukemia reveals diverse mutations in >80% of patients with TET2 and EZH2 being of high prognostic relevance

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0031605

21 January 2018

Methylation status within exon 3 of the c-myc gene as a prognostic marker in myeloma and leukaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22328940

12 December 2020

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10.1371/JOURNAL.PONE.0031605

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Europe PubMed Central

PubMed publication ID

31 July 2017

2012PLoSO...731605P

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PMC publication ID

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Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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