(Q34160786)

31 July 2017

title

Direct activation of human phospholipase C by its well known inhibitor u73122. (English)

1 reference

31 July 2017

John Sondek

8

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author name string

Ryan R Klein

1

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31 July 2017

David M Bourdon

2

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31 July 2017

Chester L Costales

3

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31 July 2017

Craig D Wagner

4

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31 July 2017

Wendy L White

5

1 reference

31 July 2017

Jon D Williams

6

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31 July 2017

Stephanie N Hicks

7

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31 July 2017

Dhiren R Thakker

9

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31 July 2017

language of work or name

English

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publication date

25 January 2011

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31 July 2017

number of pages

10

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Journal of Biological Chemistry

inferred from page(s)

published in

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31 July 2017

volume

286

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31 July 2017

issue

14

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31 July 2017

page(s)

12407-12416

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Mechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes

31 July 2017

cites work

1 reference

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The phospholipase C inhibitor U-73122 inhibits Ca2+ release from the intracellular sarcoplasmic reticulum Ca2+ store by inhibiting Ca2+ pumps in smooth muscle

5 July 2018

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General and Versatile Autoinhibition of PLC Isozymes

5 July 2018

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1-[6-[[(17beta)-3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione (U73122) selectively inhibits Kir3 and BK channels in a phospholipase C-independent fashion

5 July 2018

1 reference

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The phosphoinositide-specific phospholipase C inhibitor U73122 (1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione) spontaneously forms conjugates with common components of cell culture medium.

5 July 2018

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Stringent 3Q.1R composition of the SNARE 0-layer can be bypassed for fusion by compensatory SNARE mutation or by lipid bilayer modification.

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Signalling through phospholipase C interferes with clathrin-mediated endocytosis

5 July 2018

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5 July 2018

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Critical role of phospholipase Cgamma1 in the generation of H2O2-evoked [Ca2+]i oscillations in cultured rat cortical astrocytes

5 July 2018

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Thioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteine

5 July 2018

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5 July 2018

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Role of the lid hydrophobicity pattern in pancreatic lipase activity.

5 July 2018

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Rhythmic expression of adenylyl cyclase VI contributes to the differential regulation of serotonin N-acetyltransferase by bradykinin in rat pineal glands

5 July 2018

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5 July 2018

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Protein S-nitrosation: biochemistry and characterization of protein thiol-NO interactions as cellular signals

5 July 2018

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Redox regulation of PTEN by S-nitrosothiols

5 July 2018

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Ras plasma membrane signalling platforms

5 July 2018

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Palmitoylation of claudins is required for efficient tight-junction localization

5 July 2018

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Distinctive solution conformation of phosphatase inhibitor CPI-17 substituted with aspartate at the phosphorylation-site threonine residue

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069444

Role of phospholipase C-beta in the modulation of epithelial tight junction permeability

5 July 2018

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Phospholipase C-gamma modulates epithelial tight junction permeability through hyperphosphorylation of tight junction proteins

5 July 2018

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Solution NMR structure of the myosin phosphatase inhibitor protein CPI-17 shows phosphorylation-induced conformational changes responsible for activation

5 July 2018

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Crystal structure of the open form of dog gastric lipase in complex with a phosphonate inhibitor

5 July 2018

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Regulation of phosphoinositide-specific phospholipase C

5 July 2018

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Structure, function, and control of phosphoinositide-specific phospholipase C

5 July 2018

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The open lid mediates pancreatic lipase function.

5 July 2018

1 reference

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Crystal structure of human gastric lipase and model of lysosomal acid lipase, two lipolytic enzymes of medical interest

5 July 2018

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Interfacial activation of triglyceride lipase from Thermomyces (Humicola) lanuginosa: kinetic parameters and a basis for control of the lid.

5 July 2018

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Suppression of phospholipase C beta, gamma, and delta families alters cell growth and phosphatidylinositol 4,5-bisphosphate levels

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069444

Activation mechanism of the MAP kinase ERK2 by dual phosphorylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069444

Regulation of phosphoinositide-specific phospholipase C isozymes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069444

Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development

5 July 2018

1 reference

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Time-dependent inhibition of phospholipase C beta-catalysed phosphoinositide hydrolysis: a comparison of different assays

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069444

The making of a tight junction.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069444

Domain separation in the activation of glycogen phosphorylase a.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069444

All ras proteins are polyisoprenylated but only some are palmitoylated

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069444

Studies of inositol phospholipid-specific phospholipase C.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069444

Receptor-coupled signal transduction in human polymorphonuclear neutrophils: effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069444

Structure of human pancreatic lipase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069444

Assembly and sealing of tight junctions: possible participation of G-proteins, phospholipase C, protein kinase C and calmodulin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069444

The aminosteroid U-73122 inhibits muscarinic receptor sequestration and phosphoinositide hydrolysis in SK-N-SH neuroblastoma cells. A role for Gp in receptor compartmentation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069444

Regulation of inositol phospholipid-specific phospholipase C isozymes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069444

PLCgamma1 is essential for early events in integrin signalling required for cell motility

5 July 2018

1 reference

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In vivo activity of a phospholipase C inhibitor, 1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione (U73122), in acute and chronic inflammatory reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.191783

The aminosteroid phospholipase C antagonist U-73122 (1-[6-[[17-beta-3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione) potently inhibits human 5-lipoxygenase in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.191783

U73122, an aminosteroid phospholipase C inhibitor, is a potent inhibitor of cardiac phospholipase D by a PIP2-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.191783

Inhibition of phospholipase C-independent exocytotic responses in rat peritoneal mast cells by U73122.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110.191783

Angiotensin II inhibits bTREK-1 K+ channels in adrenocortical cells by separate Ca2+- and ATP hydrolysis-dependent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.191783

Phospholipase Cgamma-Erk Axis in vascular endothelial growth factor-induced eukaryotic initiation factor 4E phosphorylation and protein synthesis in renal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.191783

Crystallographic study of the structure of colipase and of the interaction with pancreatic lipase

21 January 2018

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21 January 2018

Controlled S-nitrosation

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https://api.crossref.org/works/10.1074%2FJBC.M110.191783

Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110.191783

Crystal structure of Rac1 bound to its effector phospholipase C-β2

21 January 2018

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Glucagon-like peptide 1 activates protein kinase C through Ca2+-dependent activation of phospholipase C in insulin-secreting cells

21 January 2018

1 reference

12 December 2020

Potent inhibition of human telomerase by U-73122

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12 December 2020

Modification of creatine kinase by S-nitrosothiols: S-nitrosation vs. S-thiolation

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12 December 2020

The interaction of U-73122 with the histamine H1 receptor: implications for the use of U-73122 in defining H1 receptor-coupled signalling pathways

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12 December 2020

Inhibition of phospholipase C dependent processes by U-73, 122

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12 December 2020

Kinetic analysis of phospholipase C beta isoforms using phospholipid-detergent mixed micelles. Evidence for interfacial catalysis involving distinct micelle binding and catalytic steps

1 reference

12 December 2020

Evidence for separate effects of U73122 on phospholipase C and calcium channels in human platelets

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12 December 2020

Identifiers

DOI

10.1074/JBC.M110.191783

1 reference

31 July 2017

1 reference

31 July 2017

1 reference