(Q34162111)

31 July 2017

title

Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease (English)

1 reference

autosomal dominant polycystic kidney disease

31 July 2017

main subject

0 references

protein ubiquitination

1 reference

autosomal dominant polycystic kidney

inferred from title

1 reference

Shan Qin

1

1 reference

31 July 2017

Mary Taglienti

2

1 reference

31 July 2017

Surya M Nauli

3

1 reference

31 July 2017

Leah Contrino

4

1 reference

31 July 2017

Ayumi Takakura

5

1 reference

31 July 2017

Jing Zhou

6

1 reference

31 July 2017

Jordan A Kreidberg

7

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31 July 2017

language of work or name

English

0 references

publication date

13 September 2010

1 reference

Journal of Clinical Investigation

31 July 2017

published in

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31 July 2017

volume

120

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31 July 2017

issue

10

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31 July 2017

page(s)

3617-3628

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Crosstalk in Met receptor oncogenesis

31 July 2017

cites work

1 reference

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Toxic tubular injury in kidneys from Pkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways

5 July 2018

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Cystic kidney diseases and planar cell polarity signaling.

5 July 2018

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Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis

5 July 2018

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Pkd1 inactivation induced in adulthood produces focal cystic disease

5 July 2018

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Role of vasopressin antagonists

5 July 2018

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Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1

5 July 2018

1 reference

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Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia.

5 July 2018

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Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1.

5 July 2018

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A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1

5 July 2018

1 reference

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HGF mediates cell proliferation of human mesothelioma cells through a PI3K/MEK5/Fra-1 pathway

5 July 2018

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Role of primary cilia in the pathogenesis of polycystic kidney disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

Laminin 5 regulates polycystic kidney cell proliferation and cyst formation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

A hypomorphic mutation in the mouse laminin alpha5 gene causes polycystic kidney disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

Cbl-mediated ubiquitination of alpha5 integrin subunit mediates fibronectin-dependent osteoblast detachment and apoptosis induced by FGFR2 activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

alpha3beta1 integrin-CD151, a component of the cadherin-catenin complex, regulates PTPmu expression and cell-cell adhesion

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

Hepatocyte growth factor switches orientation of polarity and mode of movement during morphogenesis of multicellular epithelial structures

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

Control of epithelial transport via luminal P2 receptors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

Involvement of cAMP-response element binding protein in corticotropin-releasing factor (CRF)-induced down-regulation of CRF receptor 1 gene expression in rat anterior pituitary cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

The differential distribution of acetylated and detyrosinated alpha-tubulin in the microtubular cytoskeleton and primary cilia of hyaline cartilage chondrocytes.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

Shedding of c-Met is regulated by crosstalk between a G-protein coupled receptor and the EGF receptor and is mediated by a TIMP-3 sensitive metalloproteinase.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

Compromised cytoarchitecture and polarized trafficking in autosomal dominant polycystic kidney disease cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

(Alpha)3(beta)1 integrin regulates epithelial cytoskeletal organization.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

Interaction between FGF and BMP signaling pathways regulates development of metanephric mesenchyme

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

Renal tubular hyperplasia, polycystic disease, and glomerulosclerosis in transgenic mice overexpressing hepatocyte growth factor/scatter factor.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

Basement membrane chondroitin sulfate proteoglycan alterations in a rat model of polycystic kidney disease.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

Analogs of cyclic AMP and cyclic GMP: general methods of synthesis and the relationship of structure to enzymic activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

Golgi-cilium complex in rabbit ciliary process cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

Decreased de novo synthesis of proteoglycans in drug-induced renal cystic disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

Inhibition of tubular cell proliferation by neutralizing endogenous HGF leads to renal hypoxia and bone marrow-derived cell engraftment in acute renal failure

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

Defective planar cell polarity in polycystic kidney disease

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

The integrin alpha6beta1 modulation of PI3K and Cdc42 activities induces dynamic filopodium formation in human platelets

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

Expression of hepatocyte growth factor and its receptor C-met in acquired renal cystic disease associated with renal cell carcinoma

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

Sulfonylurea-sensitive K(+) transport is involved in Cl(-) secretion and cyst trowth by cultured ADPKD cells

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

Interaction of the leucine-rich repeats of polycystin-1 with extracellular matrix proteins: possible role in cell proliferation

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

ADPKD: a human disease altering Golgi function and basolateral exocytosis in renal epithelia.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

Dysregulation of cellular proliferation and apoptosis mediates human autosomal dominant polycystic kidney disease (ADPKD).

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

Loss of Polycystin-1 in Human Cyst-Lining Epithelia Leads to Ciliary Dysfunction

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947217

Late onset of renal and hepatic cysts in Pkd1-targeted heterozygotes

28 October 2018

1 reference

12 December 2020

The beta4 integrin subunit rescues A431 cells from apoptosis through a PI3K/Akt kinase signaling pathway

1 reference

12 December 2020

Activation of Wnt/beta-catenin pathway during hepatocyte growth factor-induced hepatomegaly in mice

1 reference

12 December 2020

Early embryonic renal tubules of wild-type and polycystic kidney disease kidneys respond to cAMP stimulation with cystic fibrosis transmembrane conductance regulator/Na(+),K(+),2Cl(-) Co-transporter-dependent cystic dilation

1 reference

12 December 2020

Polycystic Kidney Disease

1 reference

12 December 2020

Polycystic kidney disease channel and synaptotagmin homologues play roles in schizosaccharomyces pombe cell wall synthesis/repair and membrane protein trafficking

1 reference

12 December 2020

[Cilia-centriole-Golgi apparatus relationships in the glandular cells of the anterior pituitary of the hedgehog (Erinaceus europaeus L)]

1 reference

12 December 2020

Reconstitution of the transport of protein between successive compartments of the Golgi measured by the coupled incorporation of N-acetylglucosamine

1 reference

12 December 2020

Comparison of proteoglycans synthesized by porcine normal and polycystic renal tubular epithelial cells in vitro

1 reference

12 December 2020

Altered synthesis and intracellular transport of proteoglycans by cyst-derived cells from human polycystic kidneys

1 reference

12 December 2020

Growth factor gene expression in kidney of murine polycystic kidney disease

1 reference

12 December 2020

Decreased synthesis and delayed processing of sulfated glycoproteins by cells from human polycystic kidneys

1 reference

12 December 2020

HGF-induced tubulogenesis and branching of epithelial cells is modulated by extracellular matrix and TGF-beta

1 reference

12 December 2020

Expression of the c-ret proto-oncogene during mouse embryogenesis

1 reference

12 December 2020

Involvement of hepatocyte growth factor in kidney development

1 reference

12 December 2020

Mediation of renal cyst formation by hepatocyte growth factor

1 reference

12 December 2020

Differential growth factor-induced modulation of proteoglycans synthesized by normal human renal versus cyst-derived cells

1 reference

12 December 2020

Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis

1 reference

12 December 2020

Insulin-like growth factor (IGF) and IGF binding protein gene expression in multicystic renal dysplasia

1 reference

12 December 2020

Acidic FGF regulation of hyperproliferation of fibroblasts in human autosomal dominant polycystic kidney disease

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI41531

1 reference

31 July 2017

1 reference

31 July 2017

1 reference