(Q34600282)

3 August 2017

The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease (English)

1 reference

polycystic kidney disease

3 August 2017

1 reference

inferred from title

author

Albrecht Kramer-Zucker

10

object named as

Albrecht Kramer-Zucker

1 reference

3 August 2017

Jonathan M Shillingford

1

1 reference

3 August 2017

Noel S Murcia

2

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3 August 2017

Claire H Larson

3

1 reference

3 August 2017

Seng Hui Low

4

1 reference

3 August 2017

Ryan Hedgepeth

5

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3 August 2017

Nicole Brown

6

1 reference

3 August 2017

Chris A Flask

7

1 reference

3 August 2017

Andrew C Novick

8

1 reference

3 August 2017

David A Goldfarb

9

1 reference

3 August 2017

Gerd Walz

11

1 reference

3 August 2017

Klaus B Piontek

12

1 reference

3 August 2017

Gregory G Germino

13

1 reference

3 August 2017

Thomas Weimbs

14

1 reference

3 August 2017

language of work or name

English

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publication date

27 March 2006

1 reference

Proceedings of the National Academy of Sciences of the United States of America

3 August 2017

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3 August 2017

103

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3 August 2017

14

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3 August 2017

5466-5471

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Rheb binds and regulates the mTOR kinase

3 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459378

Molecular pathogenesis of ADPKD: the polycystin complex gets complex

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459378

Dysregulation of the TSC-mTOR pathway in human disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459378

Tuberous sclerosis complex: from Drosophila to human disease.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459378

TSC2: filling the GAP in the mTOR signaling pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459378

Tuberous sclerosis complex: genetics to pathogenesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459378

SNAREs and epithelial cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459378

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459378

Syntaxin 2 and endobrevin are required for the terminal step of cytokinesis in mammalian cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459378

Positional cloning of jcpk/bpk locus of the mouse

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459378

Rapamycin is an effective inhibitor of human renal cancer metastasis.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459378

Autosomal dominant polycystic kidney disease: molecular genetics and pathophysiology.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459378

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459378

Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459378

Genetics and pathogenesis of polycystic kidney disease.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459378

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459378

p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459378

Tuberin-dependent membrane localization of polycystin-1: a functional link between polycystic kidney disease and the TSC2 tumor suppressor gene

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459378

Regulation of translation initiation by FRAP/mTOR

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459378

Polycystin-1, the product of the polycystic kidney disease 1 gene, co-localizes with desmosomes in MDCK cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459378

Progressive segregation of unmyelinated axons in peripheral nerves, myelin alterations in the CNS, and cyst formation in the kidneys of myelin and lymphocyte protein-overexpressing mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459378

VIP17/MAL, a lipid raft-associated protein, is involved in apical transport in MDCK cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459378

Cellular activation triggered by the autosomal dominant polycystic kidney disease gene product PKD2

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459378

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459378

Renal cystic disease in tuberous sclerosis: role of the polycystic kidney disease 1 gene

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459378

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459378

TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459378

Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459378

Kidney transplantation without calcineurin inhibitor drugs: a prospective, randomized trial of sirolimus versus cyclosporine

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459378

Relationship between renal volume growth and renal function in autosomal dominant polycystic kidney disease: a longitudinal study.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1459378

Delayed cystogenesis and increased ciliogenesis associated with the re-expression of polaris in Tg737 mutant mice

26 October 2018

1 reference

12 December 2020

Renal and biliary abnormalities in a new murine model of autosomal recessive polycystic kidney disease

1 reference

12 December 2020

Alternative splicing of the tuberous sclerosis 2 (TSC2) gene in human and mouse tissues

1 reference

12 December 2020

Cellular localization and tissue distribution of polycystin-1

1 reference

12 December 2020

A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo

1 reference

12 December 2020

Autosomal dominant polycystic kidney disease

1 reference

12 December 2020

Polycystic kidney disease

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12 December 2020

Identifiers

DOI

10.1073/PNAS.0509694103

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3 August 2017

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3 August 2017

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