(Q34162187)

31 July 2017

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title

Lymphoid malignancies: the dark side of B-cell differentiation (English)

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31 July 2017

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A L Shaffer

1

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PubMed ID

12461565

31 July 2017

Andreas Rosenwald

series ordinal

2

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PubMed ID

12461565

31 July 2017

Louis M Staudt

series ordinal

3

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31 July 2017

1 December 2002

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Nature Reviews Immunology

31 July 2017

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31 July 2017

2

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31 July 2017

920-932

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31 July 2017

12

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The RAG proteins and V(D)J recombination: complexes, ends, and transposition

31 July 2017

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V(D)J-mediated translocations in lymphoid neoplasms: a functional assessment of genomic instability by cryptic sites.

21 January 2018

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Antigen-independent appearance of recombination activating gene (RAG)-positive bone marrow B cells in the spleens of immunized mice

21 January 2018

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21 January 2018

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Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens

21 January 2018

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The function of AID in somatic mutation and class switch recombination: upstream or downstream of DNA breaks

21 January 2018

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Molecular mechanism of class switch recombination: linkage with somatic hypermutation

21 January 2018

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Somatic hypermutation of immunoglobulin genes: merging mechanisms for genetic diversity

21 January 2018

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Chromosomal breakpoints and structural alterations of the c-myc locus differ in endemic and sporadic forms of Burkitt lymphoma

21 January 2018

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Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma.

21 January 2018

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Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease

21 January 2018

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BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci

21 January 2018

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Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes.

21 January 2018

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Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

21 January 2018

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Different regions of the immunoglobulin heavy-chain locus are involved in chromosomal translocations in distinct pathogenetic forms of Burkitt lymphoma

21 January 2018

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Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma

21 January 2018

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Intraclonal generation of antibody mutants in germinal centres

21 January 2018

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The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation

21 January 2018

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CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans

21 January 2018

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Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice.

21 January 2018

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Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

21 January 2018

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Signatures of the immune response

21 January 2018

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The lymphochip: a specialized cDNA microarray for the genomic-scale analysis of gene expression in normal and malignant lymphocytes.

21 January 2018

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The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma

21 January 2018

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Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomas

21 January 2018

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Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells

21 January 2018

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Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo

21 January 2018

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Disentangling the MYC web.

21 January 2018

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Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2

21 January 2018

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A link between increased transforming activity of lymphoma-derived MYC mutant alleles, their defective regulation by p107, and altered phosphorylation of the c-Myc transactivation domain

21 January 2018

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Germinal center cells express bcl-2 protein after activation by signals which prevent their entry into apoptosis

21 January 2018

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NF-kappaB at the crossroads of life and death

21 January 2018

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Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells.

21 January 2018

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Activators and target genes of Rel/NF-kappaB transcription factors

21 January 2018

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Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18.

21 January 2018

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Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IkappaBalpha.

21 January 2018

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Clonal deleterious mutations in the IkappaBalpha gene in the malignant cells in Hodgkin's lymphoma

21 January 2018

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A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue

21 January 2018

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Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway

21 January 2018

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Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32)

21 January 2018

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Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure

21 January 2018

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Epstein-Barr virus-transforming protein latent infection membrane protein 1 activates transcription factor NF-kappaB through a pathway that includes the NF-kappaB-inducing kinase and the IkappaB kinases IKKalpha and IKKbeta

21 January 2018

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Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells.

21 January 2018

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Regulation of lymphocyte cell fate decisions and lymphomagenesis by BCL-6.

21 January 2018

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Control of inflammation, cytokine expression, and germinal center formation by BCL-6

21 January 2018

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The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation

21 January 2018

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Disruption of the Bcl6 gene results in an impaired germinal center formation

21 January 2018

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BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control.

21 January 2018

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Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6.

21 January 2018

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Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene

21 January 2018

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Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells

21 January 2018

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Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program

21 January 2018

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Repression of c-myc transcription by Blimp-1, an inducer of terminal B cell differentiation

21 January 2018

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Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor

21 January 2018

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A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling

21 January 2018

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Requirement for p27(KIP1) in retinoblastoma protein-mediated senescence

21 January 2018

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Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

21 January 2018

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Reversion of B cell commitment upon loss of Pax5 expression

21 January 2018

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Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis.

21 January 2018

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Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1

21 January 2018

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Plasma cell differentiation requires the transcription factor XBP-1

21 January 2018

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Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells

21 January 2018

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In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.

21 January 2018

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Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori

21 January 2018

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Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection. MALT Lymphoma Study Group

21 January 2018

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Hepatitis C virus infection in patients with B-cell non-Hodgkin lymphoma

21 January 2018

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Prospective study of hepatitis C viral infection as a risk factor for subsequent B-cell neoplasia

21 January 2018

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Regression of splenic lymphoma with villous lymphocytes after treatment of hepatitis C virus infection

21 January 2018

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The B-cell receptor of a hepatitis C virus (HCV)-associated non-Hodgkin lymphoma binds the viral E2 envelope protein, implicating HCV in lymphomagenesis

21 January 2018

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Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells.

21 January 2018

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Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia

21 January 2018

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Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors.

21 January 2018

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Monoclonal B lymphocytes with the characteristics of "indolent" chronic lymphocytic leukemia are present in 3.5% of adults with normal blood counts

21 January 2018

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Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia

21 January 2018

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Production of autoantibodies by CD5-expressing B lymphocytes from patients with chronic lymphocytic leukemia

21 January 2018

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Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia

21 January 2018

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Different nuclear signals are activated by the B cell receptor during positive versus negative signaling.

21 January 2018

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Transmodulation of BCR signaling by transduction-incompetent antigen receptors: implications for impaired signaling in anergic B cells

21 January 2018

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Preclinical and clinical evaluation of proteasome inhibitor PS-341 for the treatment of cancer

21 January 2018

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

21 January 2018

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Diffuse large cell lymphoma

21 January 2018

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Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.

21 January 2018

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Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning

21 January 2018

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Clinical translation of gene expression profiling in lymphomas and leukemias

21 January 2018

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Somatic hypermutation and V(H) gene usage in mantle cell lymphoma.

21 January 2018

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Chronic lymphocytic leukemia B cells can undergo somatic hypermutation and intraclonal immunoglobulin V(H)DJ(H) gene diversification.

21 January 2018

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The CD40-Inducible Bcl-2 Family Member A1 Protects B Cells from Antigen Receptor-Mediated Apoptosis

21 January 2018

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Rheumatoid arthritis and cancer risk

21 January 2018

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Analysis of the IgVH somatic mutations in splenic marginal zone lymphoma defines a group of unmutated cases with frequent 7q deletion and adverse clinical course

21 January 2018

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Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

21 January 2018

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Continued RAG expression in late stages of B cell development and no apparent re-induction after immunizion

21 January 2018

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Evolution of autoantibody responses via somatic hypermutation outside of germinal centers

21 January 2018

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The propensity to apoptosis of centrocytes and centroblasts correlates with elevated levels of intracellular myc protein

21 January 2018

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Translocation and rearrangements of the c-myc oncogene locus in human undifferentiated B-cell lymphomas

21 January 2018

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Involvement of the bcl-2 gene in human follicular lymphoma

21 January 2018

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The response of cells from low-grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue to Helicobacter pylori

21 January 2018

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Self-tolerance checkpoints in B lymphocyte development

21 January 2018

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Defective assembly of the B-cell receptor chains accounts for its low expression in B-chronic lymphocytic leukaemia

21 January 2018

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Nuclear NF-ATp is a hallmark of unstimulated B cells from B-CLL patients

21 January 2018

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The t(14;18) defines a unique subset of diffuse large B-cell lymphoma with a germinal center B-cell gene expression profile

21 January 2018

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Molecular and clinical features of non-Burkitt's, diffuse large-cell lymphoma of B-cell type associated with the c-MYC/immunoglobulin heavy-chain fusion gene

21 January 2018

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31 March 2020

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Complete remission of primary high-grade B-cell gastric lymphoma after cure of Helicobacter pylori infection

31 March 2020

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A selective defect in IgM antigen receptor synthesis and transport causes loss of cell surface IgM expression on tolerant B lymphocytes.

31 March 2020

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Ongoing somatic mutations and clonal expansions after cure of Helicobacter pylori infection in gastric mucosa-associated lymphoid tissue B-cell lymphoma

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI953

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31 July 2017

1 reference

PubMed ID

12461565