(Q34169318)

31 July 2017

title

N-naphthoyl-beta-naltrexamine (NNTA), a highly selective and potent activator of μ/kappa-opioid heteromers (English)

1 reference

31 July 2017

0 references

Ajay S Yekkirala

1

1 reference

31 July 2017

Mary M Lunzer

2

1 reference

31 July 2017

Christopher R McCurdy

3

1 reference

31 July 2017

Michael D Powers

4

1 reference

31 July 2017

Alexander E Kalyuzhny

5

1 reference

31 July 2017

Sandra C Roerig

6

1 reference

31 July 2017

Philip S Portoghese

7

1 reference

31 July 2017

language of work or name

English

0 references

publication date

8 March 2011

1 reference

Proceedings of the National Academy of Sciences of the United States of America

31 July 2017

published in

1 reference

31 July 2017

volume

108

1 reference

31 July 2017

issue

12

1 reference

31 July 2017

page(s)

5098-5103

1 reference

Standard opioid agonists activate heteromeric opioid receptors: evidence for morphine and [d-Ala(2)-MePhe(4)-Glyol(5)]enkephalin as selective μ-δ agonists

31 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064379

The delta(1) opioid receptor is a heterodimer that opposes the actions of the delta(2) receptor on alcohol intake

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064379

Design, synthesis, and biological evaluation of 6alpha- and 6beta-N-heterocyclic substituted naltrexamine derivatives as mu opioid receptor selective antagonists

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064379

Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064379

Cannabinoid receptor homo- and heterodimerization

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064379

A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064379

Opioid receptor homo- and heterodimerization in living cells by quantitative bioluminescence resonance energy transfer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064379

Heterodimerization of opioid receptor-like 1 and mu-opioid receptors impairs the potency of micro receptor agonist

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064379

Interactions between delta opioid receptors and alpha-adrenoceptors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064379

Hetero-oligomers of alpha2A-adrenergic and mu-opioid receptors do not lead to transactivation of G-proteins or altered endocytosis profiles

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064379

G protein-coupled receptor dimerization: function and ligand pharmacology

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064379

A bivalent ligand (KDN-21) reveals spinal delta and kappa opioid receptors are organized as heterodimers that give rise to delta(1) and kappa(2) phenotypes. Selective targeting of delta-kappa heterodimers

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064379

Homodimerization of the beta2-adrenergic receptor as a prerequisite for cell surface targeting

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064379

Functional interactions between mu opioid and alpha 2A-adrenergic receptors.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064379

Heterodimerization of substance P and mu-opioid receptors regulates receptor trafficking and resensitization.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064379

Heterodimerization of somatostatin and opioid receptors cross-modulates phosphorylation, internalization, and desensitization

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064379

Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064379

Is Galpha16 the optimal tool for fishing ligands of orphan G-protein-coupled receptors?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064379

G protein coupled receptor dimerization: implications in modulating receptor function

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064379

Minireview: Insights into G protein-coupled receptor function using molecular models

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064379

Heterodimerization of mu and delta opioid receptors: A role in opiate synergy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064379

G-protein-coupled receptor heterodimerization modulates receptor function

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064379

Narcotic antagonistic potency of bivalent ligands which contain beta-naltrexamine. Evidence for bridging between proximal recognition sites

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064379

Synthesis and opioid antagonist potencies of naltrexamine bivalent ligands with conformationally restricted spacers

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064379

Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064379

Coexpression of delta-opioid receptors with micro receptors in GH3 cells changes the functional response to micro agonists from inhibitory to excitatory.

5 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1016277108

Heterodimerization and cross-desensitization between the mu-opioid receptor and the chemokine CCR5 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1016277108

Trafficking of preassembled opioid mu-delta heterooligomer-Gz signaling complexes to the plasma membrane: coregulation by agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1016277108

Induced association of mu opioid (MOP) and type 2 cholecystokinin (CCK2) receptors by novel bivalent ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1016277108

Absence of conditioned place preference or reinstatement with bivalent ligands containing mu-opioid receptor agonist and delta-opioid receptor antagonist pharmacophores

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1016277108

A novel opioid receptor site directed alkylating agent with irreversible narcotic antagonistic and reversible agonistic activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1016277108

Development of antinociceptive tolerance and physical dependence following morphine i.c.v. infusion in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1016277108

Selectivity of delta- and kappa-opioid ligands depends on the route of central administration in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1016277108

Coexistence of kappa- and delta-opioid receptors in rat spinal cord axons

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1016277108

MU-opioid receptor-knockout mice: role of mu-opioid receptor in morphine mediated immune functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1016277108

Oxytocin and Vasopressin V1a and V2 Receptors Form Constitutive Homo- and Heterodimers during Biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1016277108

21 January 2018

Identifiers

DOI

10.1073/PNAS.1016277108

1 reference

release_tutdzezzlzaodpjcvlwj23vtna

31 July 2017

0 references

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/tutdzezzlzaodpjcvlwj23vtna

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

3064379

1 reference

31 July 2017

1 reference