(Q34171550)

31 July 2017

title

A radically different mechanism for S-adenosylmethionine-dependent methyltransferases (English)

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rRNA (adenine-C2-)-methyltransferase activity

31 July 2017

main subject

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Gene Ontology release 2020-05-02

Carsten Krebs

6

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author name string

Tyler L Grove

1

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31 July 2017

Jack S Benner

2

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31 July 2017

Matthew I Radle

3

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31 July 2017

Jessica H Ahlum

4

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31 July 2017

Bradley J Landgraf

5

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31 July 2017

Squire J Booker

7

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31 July 2017

language of work or name

English

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publication date

17 March 2011

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31 July 2017

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31 July 2017

volume

332

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31 July 2017

issue

6029

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31 July 2017

page(s)

604-607

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The bacterial ribosome as a target for antibiotics

31 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

Ribosome biogenesis and the translation process in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

Expanding the nucleotide repertoire of the ribosome with post-transcriptional modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

Posttranscriptional modification of the central loop of domain V in Escherichia coli 23 S ribosomal RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

From the structure and function of the ribosome to new antibiotics (Nobel Lecture).

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

Erythromycin resistance by ribosome modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

A 9 A resolution X-ray crystallographic map of the large ribosomal subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

High resolution structure of the large ribosomal subunit from a mesophilic eubacterium

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

Structures of the bacterial ribosome at 3.5 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

Structure of the 70S ribosome complexed with mRNA and tRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

The methyltransferase YfgB/RlmN is responsible for modification of adenosine 2503 in 23S rRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

The Cfr rRNA methyltransferase confers resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

Identification of a plasmid-borne chloramphenicol-florfenicol resistance gene in Staphylococcus sciuri

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

Anaerobic functionalization of unactivated C-H bonds

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

S-Adenosylmethionine-dependent radical-based modification of biological macromolecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

Radical mechanisms of S-adenosylmethionine-dependent enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

Lipoyl synthase requires two equivalents of S-adenosyl-L-methionine to synthesize one equivalent of lipoic acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

A consensus mechanism for Radical SAM-dependent dehydrogenation? BtrN contains two [4Fe-4S] clusters

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

High-level expression and reconstitution of active Cfr, a radical-SAM rRNA methyltransferase that confers resistance to ribosome-acting antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

Biotin synthase, a new member of the family of enzymes which uses S-adenosylmethionine as a source of deoxyadenosyl radical.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

9-Mercaptodethiobiotin is formed as a competent catalytic intermediate by Escherichia coli biotin synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

Cloning of the pactamycin biosynthetic gene cluster and characterization of a crucial glycosyltransferase prior to a unique cyclopentane ring formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

Chlorophyll biosynthesis in bacteria: the origins of structural and functional diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

Bioactive natural products with carbon-phosphorus bonds and their biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

Rings, radicals, and regeneration: the early years of a bioorganic laboratory

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1200877

21 January 2018

Identifiers

DOI

10.1126/SCIENCE.1200877

1 reference

31 July 2017

1 reference