(Q34173511)

31 July 2017

1 reference

title

Serotonin receptors and heart valve disease--it was meant 2B. (English)

1 reference

31 July 2017

0 references

Joshua D Hutcheson

1

1 reference

31 July 2017

Vincent Setola

series ordinal

2

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31 July 2017

Bryan L Roth

series ordinal

3

1 reference

31 July 2017

W David Merryman

series ordinal

4

1 reference

31 July 2017

publication date

2 April 2011

1 reference

Pharmacology & Therapeutics

31 July 2017

published in

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31 July 2017

volume

132

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31 July 2017

issue

2

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31 July 2017

page(s)

146-157

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Serotonin receptors - from molecular biology to clinical applications

31 July 2017

cites work

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5 July 2018

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5 July 2018

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Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy

5 July 2018

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Serotonin 5-HT(2B) receptor blockade prevents reactive oxygen species-induced cardiac hypertrophy in mice

5 July 2018

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Angiotensin II blockade and aortic-root dilation in Marfan's syndrome

5 July 2018

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5 July 2018

Carcinoid heart disease

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5-hydroxytryptamine (5HT)-induced valvulopathy: compositional valvular alterations are associated with 5HT2B receptor and 5HT transporter transcript changes in Sprague-Dawley rats

5 July 2018

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Transforming growth factor beta1 induces alphavbeta3 integrin expression in human lung fibroblasts via a beta3 integrin-, c-Src-, and p38 MAPK-dependent pathway

5 July 2018

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Serotonin 5-HT2B receptors are required for 3,4-methylenedioxymethamphetamine-induced hyperlocomotion and 5-HT release in vivo and in vitro

5 July 2018

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TGF-beta1-induced plasminogen activator inhibitor-1 expression in vascular smooth muscle cells requires pp60(c-src)/EGFR(Y845) and Rho/ROCK signaling

5 July 2018

1 reference

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Serum vasoconstrictor, serotonin; isolation and characterization

5 July 2018

1 reference

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Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix

5 July 2018

1 reference

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Possible association between 3,4-methylenedioxymethamphetamine abuse and valvular heart disease

5 July 2018

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Synergistic effects of cyclic tension and transforming growth factor-beta1 on the aortic valve myofibroblast

5 July 2018

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Fibrotic heart-valve reactions to dopamine-agonist treatment in Parkinson's disease

5 July 2018

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Molecular and functional characteristics of heart-valve interstitial cells

5 July 2018

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Functions of serotonin in hypoxic pulmonary vascular remodeling

5 July 2018

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Long-term serotonin effects in the rat are prevented by terguride.

5 July 2018

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Angiotensin II type 1 receptor blockade attenuates TGF-beta-induced failure of muscle regeneration in multiple myopathic states

5 July 2018

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Valvular heart disease and the use of dopamine agonists for Parkinson's disease

5 July 2018

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Dopamine agonists and the risk of cardiac-valve regurgitation

5 July 2018

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Drugs and valvular heart disease

5 July 2018

1 reference

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An ex vivo study of the biological properties of porcine aortic valves in response to circumferential cyclic stretch

5 July 2018

1 reference

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Mechanical stress enhances serotonin 2B receptor modulating brain natriuretic peptide through nuclear factor-kappaB in cardiomyocytes

5 July 2018

1 reference

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5-hydroxytryptamine receptors in the human cardiovascular system

5 July 2018

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Pathogenesis of calcific aortic valve disease: a disease process comes of age (and a good deal more).

5 July 2018

1 reference

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Lisuride, a dopamine receptor agonist with 5-HT2B receptor antagonist properties: absence of cardiac valvulopathy adverse drug reaction reports supports the concept of a crucial role for 5-HT2B receptor agonism in cardiac valvular fibrosis

5 July 2018

1 reference

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Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome

5 July 2018

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The effects of cellular contraction on aortic valve leaflet flexural stiffness.

5 July 2018

1 reference

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A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis

5 July 2018

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Molecular and cellular mechanisms for the polarized sorting of serotonin receptors: relevance for genesis and treatment of psychosis

5 July 2018

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Molecular determinants for the interaction of the valvulopathic anorexigen norfenfluramine with the 5-HT2B receptor

5 July 2018

1 reference

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Long-term serotonin administration induces heart valve disease in rats.

5 July 2018

1 reference

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Spatial heterogeneity of endothelial phenotypes correlates with side-specific vulnerability to calcification in normal porcine aortic valves.

5 July 2018

1 reference

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5 July 2018

Mining the receptorome

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Involvement of the serotonin 5-HT2B receptor in cardiac hypertrophy linked to sympathetic stimulation: control of interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha cytokine production by ventricular fibroblasts

5 July 2018

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TGF-beta1 and angiotensin networking in cardiac remodeling

5 July 2018

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G-protein-coupled receptors at a glance

5 July 2018

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The relative activities of some tryptamine analogues on the isolated rat stomach strip preparation

5 July 2018

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Hypercholesterolemic aortic-valve disease

5 July 2018

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3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro

5 July 2018

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Serotonin mechanisms in heart valve disease II: the 5-HT2 receptor and its signaling pathway in aortic valve interstitial cells

5 July 2018

1 reference

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Serotonin mechanisms in heart valve disease I: serotonin-induced up-regulation of transforming growth factor-beta1 via G-protein signal transduction in aortic valve interstitial cells

5 July 2018

1 reference

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Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. III. Agonist and antagonist properties at serotonin, 5-HT(1) and 5-HT(2), receptor subtypes

5 July 2018

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Evolution of cell phenotype and extracellular matrix in tissue-engineered heart valves during in-vitro maturation and in-vivo remodeling.

5 July 2018

1 reference

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Molecular biology of serotonin receptors structure and function at the molecular level

5 July 2018

1 reference

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Atorvastatin inhibits hypercholesterolemia-induced cellular proliferation and bone matrix production in the rabbit aortic valve

5 July 2018

1 reference

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Multiplicity of mechanisms of serotonin receptor signal transduction

5 July 2018

1 reference

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The serotonin binding site of human and murine 5-HT2B receptors: molecular modeling and site-directed mutagenesis

5 July 2018

1 reference

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5-hydroxytryptamine2A receptor inverse agonists as antipsychotics

5 July 2018

1 reference

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Ablation of serotonin 5-HT(2B) receptors in mice leads to abnormal cardiac structure and function

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications

5 July 2018

1 reference

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Serotonin 2B receptor is required for heart development

5 July 2018

1 reference

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PDZ-dependent activation of nitric-oxide synthases by the serotonin 2B receptor

5 July 2018

1 reference

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5-hydroxytryptamine 2B receptor regulates cell-cycle progression: cross-talk with tyrosine kinase pathways

5 July 2018

1 reference

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Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine

5 July 2018

1 reference

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A review of central 5-HT receptors and their function

5 July 2018

1 reference

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The prevalence of cardiac valvular insufficiency assessed by transthoracic echocardiography in obese patients treated with appetite-suppressant drugs

5 July 2018

1 reference

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Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line. Involvement of arachidonic acid metabolism

5 July 2018

1 reference

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Valvular heart disease associated with fenfluramine-phentermine

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Clinical factors associated with calcific aortic valve disease. Cardiovascular Health Study

5 July 2018

1 reference

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Sequential onset of three 5-HT receptors during the 5-hydroxytryptaminergic differentiation of the murine 1C11 cell line.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Localization of the 5-hydroxytryptamine2C receptor protein in human and rat brain using specific antisera.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Immunohistochemical localisation of the serotonin 5-HT2B receptor in mouse gut, cardiovascular system, and brain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Ras involvement in signal transduction by the serotonin 5-HT2B receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Accumulation of T lymphocytes and expression of interleukin-2 receptors in nonrheumatic stenotic aortic valves

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Molecular cloning, functional expression, and mRNA tissue distribution of the human 5-hydroxytryptamine2B receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Expression of serotonin receptor mRNAs in blood vessels

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Selective 5HT-2 antagonists inhibit serotonin stimulated phosphatidylinositol metabolism in cerebral cortex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

A double-blind clinical trial in weight control. Use of fenfluramine and phentermine alone and in combination

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Fibrotic Disorders Associated with Methysergide Therapy for Headache

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Development and progression of aortic valve stenosis: atherosclerosis risk factors--a causal relationship? A clinical morphologic study

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Valve disease associated with ergot alkaloid use: echocardiographic and pathologic correlations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Methysergide-induced heart disease: a case of multivalvular and myocardial fibrosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Valvular heart disease associated with benfluorex therapy: results from the French multicentre registry.

5 July 2018

1 reference

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Inflammatory aneurysm of the abdominal aorta in a patient treated with ropinirole

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Dose dependency and reversibility of serotonin-induced valvular heart disease in rats.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Platelet derived serotonin drives the activation of rat cardiac fibroblasts by 5-HT2A receptors

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Fluoxetine-mediated 5-HT2B receptor stimulation in astrocytes causes EGF receptor transactivation and ERK phosphorylation

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Src kinases in systemic sclerosis: central roles in fibroblast activation and in skin fibrosis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Modulation of bleomycin-induced lung fibrosis by serotonin receptor antagonists in mice.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Differences in tissue-remodeling potential of aortic and pulmonary heart valve interstitial cells.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

TGF-beta-regulated collagen type I accumulation: role of Src-based signals.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Human semilunar cardiac valve remodeling by activated cells from fetus to adult: implications for postnatal adaptation, pathology, and tissue engineering.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Biaixal stress-stretch behavior of the mitral valve anterior leaflet at physiologic strain rates.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Pizotyline effectively attenuates the stimulus effects of N-methyl-3,4-methylenedioxyamphetamine (MDMA).

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

5-Hydroxytryptamine (5HT) receptors in the heart valves of cynomolgus monkeys and Sprague-Dawley rats

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Dynamic and reversible changes of interstitial cell phenotype during remodeling of cardiac valves.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Valvular myofibroblast activation by transforming growth factor-beta: implications for pathological extracellular matrix remodeling in heart valve disease.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Identification of enteramine, the specific hormone of the enterochromaffin cell system, as 5-hydroxytryptamine.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

An assessment of the effects of serotonin 6 (5-HT6) receptor antagonists in rodent models of learning

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Overexpression of the serotonin 5-HT2B receptor in heart leads to abnormal mitochondrial function and cardiac hypertrophy

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Valvular heart disease in patients taking pergolide

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Effect of hydroxymethylglutaryl coenzyme a reductase inhibitors on the progression of calcific aortic stenosis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Association of coronary risk factors and use of statins with progression of mild valvular aortic stenosis in older persons

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Aortic valve sclerosis and aortic atherosclerosis: different manifestations of the same disease? Insights from a population-based study

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3179857

Evaluation of glycosaminoglycans content and 5-hydroxytryptamine 2B receptor in the heart valves of Sprague-Dawley rats with spontaneous mitral valvulopathy--a possible exacerbation by dl-amphetamine sulfate in Fischer 344 rats?

28 October 2018

1 reference

12 December 2020

Valvular heart disease in a patient taking benfluorex

1 reference

12 December 2020

Expression of HLA-DR antigen and smooth muscle cell differentiation markers by valvular fibroblasts in degenerative aortic stenosis

1 reference

12 December 2020

Insights into (the interstitium of) degenerative aortic valve disease

1 reference

12 December 2020

Apolipoproteins B, (a), and E accumulate in the morphologically early lesion of 'degenerative' valvular aortic stenosis

1 reference

12 December 2020

Aortic recognition sites for serotonin (5HT) are coupled to phospholipase C and modulate phosphatidylinositol turnover

1 reference

12 December 2020

The pathogenesis of atherosclerosis of the mitral and aortic valves

1 reference

12 December 2020

Cardiac and pulmonary fibrosis during methysergide therapy for headache

1 reference

12 December 2020

Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies

1 reference

12 December 2020

Association of Angiotensin-Converting Enzyme With Low-Density Lipoprotein in Aortic Valvular Lesions and in Human Plasma

1 reference

12 December 2020

Correlation between heart valve interstitial cell stiffness and transvalvular pressure: implications for collagen biosynthesis

1 reference

12 December 2020

5-Hydroxytryptamine2-family receptors (5-hydroxytryptamine2A, 5-hydroxytryptamine2B, 5-hydroxytryptamine2C): where structure meets function

1 reference

12 December 2020

Kinetic analysis of the inhibition of the epidermal growth factor receptor tyrosine kinase by Lavendustin-A and its analogue

1 reference

12 December 2020

Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values

1 reference

12 December 2020

Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves

1 reference

12 December 2020

Elevated cyclic stretch alters matrix remodeling in aortic valve cusps: implications for degenerative aortic valve disease

1 reference

12 December 2020

Benfluorex: the last chapter of drug-induced valvular heart disease?

1 reference

12 December 2020

10.1016/J.PHARMTHERA.2011.03.008

Identifiers

DOI

1 reference

31 July 2017

1 reference

31 July 2017

1 reference