(Q34180248)

31 July 2017

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title

Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients (English)

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31 July 2017

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C Lee

1

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31 July 2017

V D Longo

series ordinal

2

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31 July 2017

language of work or name

English

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publication date

25 April 2011

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31 July 2017

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31 July 2017

volume

30

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31 July 2017

issue

30

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31 July 2017

page(s)

3305-3316

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Effects of caloric restriction and growth hormone resistance on insulin-related intermediates in the skeletal muscle.

31 July 2017

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Does damage to DNA and other macromolecules play a role in aging? If so, how?

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Timeline: Chemotherapy and the war on cancer.

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Collateral damage in cancer chemotherapy: oxidative stress in nontargeted tissues

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Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein

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Nutritional regulation of IGF-I and IGF binding proteins

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Caloric restriction delays disease onset and mortality in rhesus monkeys

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Chemotherapy-associated oxidative stress: impact on chemotherapeutic effectiveness

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Assessment of growth parameters and life span of GHR/BP gene-disrupted mice.

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LACTIC ACIDOSIS AND DEATH AFTER THE TREATMENT OF OBESITY BY FASTING.

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Base-excision repair of oxidative DNA damage

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Fasting is neuroprotective following traumatic brain injury.

21 January 2018

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Nutrition and physical activity during and after cancer treatment: an American Cancer Society guide for informed choices

21 January 2018

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Effect of age and moderate food restriction on insulin sensitivity in Wistar rats: role of adiposity

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Sir2 blocks extreme life-span extension.

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Regulation of longevity and stress resistance by Sch9 in yeast

21 January 2018

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Effect of a protein and energy dense N-3 fatty acid enriched oral supplement on loss of weight and lean tissue in cancer cachexia: a randomised double blind trial

21 January 2018

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Protein metabolism in rats during long-term dietary restriction: influence of aging

21 January 2018

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Extending healthy life span--from yeast to humans

21 January 2018

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Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans.

21 January 2018

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Role of insulin-like signalling in Drosophila lifespan

21 January 2018

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Protective effect of fasting upon cerebral hypoxic-ischemic injury.

21 January 2018

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Medically supervised water-only fasting in the treatment of hypertension

21 January 2018

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Initial cost of care results in medically supervised water-only fasting for treating high blood pressure and diabetes

21 January 2018

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Differential effects of intermittent feeding and voluntary exercise on body weight and lifespan in adult rats

21 January 2018

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Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions

21 January 2018

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Genetic pathways that regulate ageing in model organisms

21 January 2018

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21 January 2018

The Hallmarks of Cancer

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https://api.crossref.org/works/10.1038%2FONC.2011.91

Stress resistance and aging: influence of genes and nutrition.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.91

Sixteen hours of fasting differentially affects hepatic and muscle insulin sensitivity in mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.91

Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.91

Caloric restriction in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.91

Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.91

Calorie restriction, aging, and cancer prevention: mechanisms of action and applicability to humans

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.91

Calorie restriction delays spontaneous tumorigenesis in p53-knockout transgenic mice

21 January 2018

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Nutritional and hormonal factors control the gene expression of FoxOs, the mammalian homologues of DAF-16

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.91

Dietary components that regulate serum somatomedin-C concentrations in humans

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.91

21 January 2018

Cancer statistics, 2010

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Starvation-induced cross protection against heat or H2O2 challenge in Escherichia coli

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.91

Fasting - the ultimate diet?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Preneoplastic changes persist after IGF-IR downregulation and tumor regression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Tumours with PI3K activation are resistant to dietary restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

A conserved regulatory system for aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Chemotherapy and neutropenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Lessons from hereditary colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Calorie restriction and susceptibility to intact pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Autophagy and the integrated stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Aging and resistance to oxidative damage in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Treatment resistant small cell carcinoma of the cervix.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Desirable cell death during anticancer chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Mutations in signal transduction proteins increase stress resistance and longevity in yeast, nematodes, fruit flies, and mammalian neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Human Bcl-2 reverses survival defects in yeast lacking superoxide dismutase and delays death of wild-type yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Evolutionary medicine: from dwarf model systems to healthy centenarians?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Calorie restriction and cancer prevention: metabolic and molecular mechanisms

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.91

Principles of cancer therapy: oncogene and non-oncogene addiction

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.91

Chemotherapy and radiotherapy: cryptic anticancer vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polzeta-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Fasting prior to transient cerebral ischemia reduces delayed neuronal necrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Ammonia: a diffusible factor released by proliferating cells that induces autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Defences against oxidative stress during starvation in bacteria

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.91

Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.91

Comparison of carbohydrate and lipid metabolism in mice and rats during fasting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Growth hormone secretion in starvation: a reassessment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Insulin-like growth factors in the fed and fasted states.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Incorporation of fasting therapy in an integrative medicine ward: evaluation of outcome, safety, and effects on lifestyle adherence in a large prospective cohort study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

The p66shc adaptor protein controls oxidative stress response and life span in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Short-term dietary restriction and fasting precondition against ischemia reperfusion injury in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Antiangiogenic and proapoptotic effects of dietary restriction on experimental mouse and human brain tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Stress resistance in long-lived mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

The role of high rates of glycolysis and glutamine utilization in rapidly dividing cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2011.91

The metabolic role of growth hormone in humans with particular reference to fasting

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

One year of caloric restriction in humans: feasibility and effects on body composition and abdominal adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

The Warburg effect suppresses oxidative stress induced apoptosis in a yeast model for cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Prolonged Starvation--A Dangerous Procedure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Assessment of the role of the glucocorticoid system in aging processes and in the action of food restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Fasting and cancer treatment in humans: A case series report.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Free radical generation in human leukocytes by CIS-unsaturated fatty acids is a calmodulin dependent process

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Feeding activates protein synthesis in mouse pancreas at the translational level without increase in mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

The metabolic events of starvation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

21 January 2018

The phenomenon of famine

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Calorie restriction as an anti-invasive therapy for malignant brain cancer in the VM mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Resistance and augmentation of innate immunity in mice exposed to starvation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Death during therapeutic starvation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Effects of prolonged food deprivation on the ultradian growth hormone rhythm and immunoreactive somatostatin tissue levels in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Treatment of obesity by total fasting for up to 249 days

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Cachexia in cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

The effects of total starvation upon the levels of circulating glucagon and insulin in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Disorders of gluconeogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

The use of preoperative nutritional interventions to protect against hepatic ischemia-reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Understanding the Warburg effect: the metabolic requirements of cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Strong dietary restrictions protect Drosophila against anoxia/reoxygenation injuries

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Cancer genes and the pathways they control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

The comparative physiology of food deprivation: from feast to famine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Age, severe comorbidity and functional impairment independently contribute to poor survival in cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Modification of age-related immune decline in mice dietarily restricted from or after midadulthood

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Long-term starvation and ageing induce AGE-1/PI 3-kinase-dependent translocation of DAF-16/FOXO to the cytoplasm

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

PI3K pathway alterations in cancer: variations on a theme

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Physiological role of the insulin-like growth factor binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Influence of Age and Long-term Dietary Restriction on Plasma Insulin-like Growth Factor-1 (IGF-1), IGF-1 Gene Expression, and IGF-1 Binding Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Catalase expression in delayed and premature aging mouse models

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Effects of growth hormone and insulin-like growth factor-1 on hepatocyte antioxidative enzymes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

PROLONGED STARVATION AS TREATMENT FOR SEVERE OBESITY.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Lipid peroxidation products, and vitamin and trace element status in patients with cancer before and after chemotherapy, including adriamycin. A preliminary study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Long-term low-protein, low-calorie diet and endurance exercise modulate metabolic factors associated with cancer risk

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Gross fragmentation of cardiac myofibrils after therapeutic starvation for obesity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Lifetime breeding studies in fully fed and dietary restricted female CFY Sprague-Dawley rats. 1. Effect of age, housing conditions and diet on fecundity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Diet and cancer prevention studies in p53-deficient mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

They starved so that others be better fed: remembering Ancel Keys and the Minnesota experiment

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Mitotic Activity in Mice is Suppressed by Energy Restriction-Induced Torpor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Caloric restriction and cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Chemoprotectants: a review of their clinical pharmacology and therapeutic efficacy.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Lipid peroxides in the polychemotherapy of cancer patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Effects of 36 hour fasting on GH/IGF-I axis and metabolic parameters in patients with simple obesity. Comparison with normal subjects and hypopituitary patients with severe GH deficiency

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Temporary nutritional stress and infertility in female mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Neuroendocrine control of growth hormone secretion

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Enhanced cell proliferation and biosynthesis mediate improved wound repair in refed, caloric-restricted mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Methionine restriction increases blood glutathione and longevity in F344 rats.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Neurodegeneration and regeneration in the CNS. New roles of heat shock proteins, nitric oxide and carbon monoxide

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Lifespan extension by reduction of the growth hormone‐insulin‐like growth factor‐1 axis: relation to caloric restriction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Dietary energy restriction in mice reduces hepatic expression of glucose-regulated protein 78 (BiP) and 94 mRNA.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Dietary restriction of single essential amino acids reduces plasma insulin-like growth factor-I (IGF-I) but does not affect plasma IGF-binding protein-1 in rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Regulation of insulin-like growth factor-I in starvation and injury.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Alternate-day fasting and chronic disease prevention: a review of human and animal trials

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Effects of dietary calorie restriction or exercise on the PI3K and Ras signaling pathways in the skin of mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Type 5 adenylyl cyclase disruption increases longevity and protects against stress

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

Effects of total energy withdrawal (fasting) on thelevels of growth hormone, thyrotropin, cortisol, adrenaline, noradrenaline, T4, T3, and rT3 in healthy males

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.91

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/ONC.2011.91

1 reference

Dimensions Publication ID

31 July 2017

1042172925

0 references

1 reference