(Q34181023)

31 July 2017

title

SOST and DKK: Antagonists of LRP Family Signaling as Targets for Treating Bone Disease (English)

1 reference

31 July 2017

James J Mason

1

1 reference

31 July 2017

Bart O Williams

series ordinal

2

1 reference

31 July 2017

publication date

1 July 2010

1 reference

31 July 2017

published in

Journal of Osteoporosis

1 reference

31 July 2017

volume

2010

1 reference

Creative Commons Attribution 3.0 Unported

31 July 2017

copyright license

start time

1 January 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

copyrighted

0 references

cites work

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis

5 July 2018

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Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis

5 July 2018

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Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease

5 July 2018

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5 July 2018

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Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling

5 July 2018

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SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

5 July 2018

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Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation

5 July 2018

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5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2951123

Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2951123

Sclerostin inhibition of Wnt-3a-induced C3H10T1/2 cell differentiation is indirect and mediated by bone morphogenetic proteins

5 July 2018

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Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6

5 July 2018

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5 July 2018

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5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2951123

Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2951123

Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

5 July 2018

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A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population

5 July 2018

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5 July 2018

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Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

5 July 2018

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Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease

5 July 2018

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A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

5 July 2018

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5 July 2018

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Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse

5 July 2018

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Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

5 July 2018

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Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

5 July 2018

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5 July 2018

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Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

5 July 2018

1 reference

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Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein

5 July 2018

1 reference

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An LDL-receptor-related protein mediates Wnt signalling in mice

5 July 2018

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5 July 2018

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arrow encodes an LDL-receptor-related protein essential for Wingless signalling

5 July 2018

1 reference

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Localization of the gene for sclerosteosis to the van Buchem disease-gene region on chromosome 17q12-q21

5 July 2018

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beta-catenin is a target for the ubiquitin-proteasome pathway

5 July 2018

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Osteoprotegerin: a novel secreted protein involved in the regulation of bone density

5 July 2018

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A molecular mechanism for the effect of lithium on development

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5 July 2018

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5 July 2018

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5 July 2018

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21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2010%2F460120

Inhibiting the inhibitor: a new route to bone anabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2010%2F460120

Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2010%2F460120

A short treatment with an antibody to sclerostin can inhibit bone loss in an ongoing model of colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2010%2F460120

Bone anabolic effects of parathyroid hormone are blunted by deletion of the Wnt antagonist secreted frizzled-related protein-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2010%2F460120

Dkk-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2010%2F460120

The prognostic significance of BMP-6 signaling in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2010%2F460120

Cyclo-oxygenase 2 function is essential for bone fracture healing

21 January 2018

1 reference

https://api.crossref.org/works/10.4061%2F2010%2F460120

Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass

21 January 2018

1 reference

12 December 2020

Transcriptional profiling of bone regeneration. Insight into the molecular complexity of wound repair

1 reference

12 December 2020

Sclerostin and Wnt signaling--the pathway to bone strength

1 reference

12 December 2020

Dickkopf-1 is a master regulator of joint remodeling

1 reference

12 December 2020

1 reference

12 December 2020

sFRPs: a declaration of (Wnt) independence

1 reference

12 December 2020

Identifiers

DOI

10.4061/2010/460120

1 reference

31 July 2017

1 reference

31 July 2017

1 reference