(Q34185019)

31 July 2017

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title

Pharmacokinetics of selective estrogen receptor modulators (English)

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31 July 2017

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Karla C Morello

1

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31 July 2017

Gregory T Wurz

series ordinal

2

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31 July 2017

Michael W DeGregorio

series ordinal

3

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31 July 2017

1 January 2003

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Clinical Pharmacokinetics

31 July 2017

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31 July 2017

42

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31 July 2017

4

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31 July 2017

361-372

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https://scigraph.springernature.com/pub.10.2165/00003088-200342040-00004

31 July 2017

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1 reference

12 December 2020

Postmenopausal hormone therapy, SERMs, and coronary heart disease in women

1 reference

12 December 2020

The pharmacology and clinical uses of tamoxifen

1 reference

12 December 2020

The metabolism of tamoxifen by human cytochromes P450 is rationalized by molecular modelling of the enzyme-substrate interactions: potential importance to its proposed anti-carcinogenic/carcinogenic actions

1 reference

12 December 2020

Impact of tamoxifen on the pharmacokinetics and endocrine effects of the aromatase inhibitor letrozole in postmenopausal women with breast cancer

1 reference

12 December 2020

Comparison of bioavailability in man of tamoxifen after oral and rectal administration

1 reference

12 December 2020

Clinical pharmacology of tamoxifen and N-desmethyltamoxifen in patients with advanced breast cancer

1 reference

12 December 2020

The bioavailability of Tamoplex (tamoxifen). Part 1. A pilot study

1 reference

12 December 2020

Biodistribution and scintigraphy of 11C-toremifene in rats bearing DMBA-induced mammary carcinoma

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12 December 2020

LY353381.HCl: a novel raloxifene analog with improved SERM potency and efficacy in vivo

1 reference

12 December 2020

Pharmacokinetics and bioavailability of tamoxifen in postmenopausal healthy women

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12 December 2020

Selective estrogenic effects of a novel triphenylethylene compound, FC1271a, on bone, cholesterol level, and reproductive tissues in intact and ovariectomized rats

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12 December 2020

Elevated plasma tamoxifen levels in a patient with liver obstruction

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12 December 2020

Effects of ospemifene (FC-1271a) on uterine endometrium, vaginal maturation index, and hormonal status in healthy postmenopausal women

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12 December 2020

Decreased serum concentrations of tamoxifen and its metabolites induced by aminoglutethimide

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12 December 2020

Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators

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12 December 2020

A phase III comparison of two toremifene doses to tamoxifen in postmenopausal women with advanced breast cancer. Eastern European Study Group

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12 December 2020

Divergent effects of raloxifene HCI on the pharmacokinetics and pharmacodynamics of warfarin

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12 December 2020

Influence of age on toremifene pharmacokinetics

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12 December 2020

Phase III trials of toremifene vs tamoxifen.

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12 December 2020

Tamoxifen in the treatment of breast cancer

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12 December 2020

Pharmacokinetics and bioavailability of tamoxifen in healthy volunteers

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12 December 2020

Comparison of effects of tamoxifen and toremifene on bone biochemistry and bone mineral density in postmenopausal breast cancer patients

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12 December 2020

Binding of toremifene to human serum proteins

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12 December 2020

Adjuvant trials of toremifene vs tamoxifen: the European experience.

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12 December 2020

Cytochrome P-450 3A and 2D6 catalyze ortho hydroxylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: involvement of catechols in covalent binding to hepatic proteins.

1 reference

12 December 2020

Pharmacokinetics of the novel antiestrogenic agent toremifene in subjects with altered liver and kidney function.

1 reference

12 December 2020

Clinical pharmacology of tamoxifen in patients with breast cancer: comparison of traditional and loading dose schedules

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12 December 2020

Toremifene. A review of its pharmacological properties and clinical efficacy in the management of advanced breast cancer

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12 December 2020

Raloxifene: A selective estrogen receptor modulator (SERM) with multiple target system effects

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12 December 2020

Effect of impaired renal function on tamoxifen

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12 December 2020

Effects of raloxifene on serum lipids and coagulation factors in healthy postmenopausal women

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12 December 2020

Biochemical and pharmacological effects of toremifene metabolites

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12 December 2020

Endometrial cancer in tamoxifen-treated breast cancer patients: findings from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14.

1 reference

12 December 2020

Pharmacokinetics of (deaminohydroxy)toremifene in humans: a new, selective estrogen-receptor modulator

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12 December 2020

Effect of low dose tamoxifen on the insulin-like growth factor system in healthy women

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12 December 2020

Involvement of cytochrome P450 3A enzyme family in the major metabolic pathways of toremifene in human liver microsomes

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12 December 2020

In vitro and in vivo biologic effects of Ospemifene (FC-1271a) in breast cancer

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12 December 2020

The metabolism of tamoxifen (I.C.I. 46,474). II. In female patients

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12 December 2020

Tamoxifen and toremifene concentrations in plasma are greatly decreased by rifampin

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12 December 2020

Studies on the metabolism and pharmacokinetics of tamoxifen in normal volunteers

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12 December 2020

Clinical pharmacokinetics of toremifene

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12 December 2020

Treatment of postmenopausal women with osteoporosis or low bone density with raloxifene. Raloxifene Study Group.

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12 December 2020

Phase I study of a third-generation selective estrogen receptor modulator, LY353381.HCL, in metastatic breast cancer

1 reference

12 December 2020

Phase I clinical and pharmacokinetics study of high-dose toremifene in postmenopausal patients with advanced breast cancer

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12 December 2020

Evaluation of tamoxifen plus letrozole with assessment of pharmacokinetic interaction in postmenopausal women with metastatic breast cancer

1 reference

12 December 2020

The selective uptake of tamoxifen by human uterine tissue

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12 December 2020

Life threatening interaction between tamoxifen and warfarin.

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12 December 2020

Clinical pharmacokinetics of endocrine agents used in advanced breast cancer

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12 December 2020

Raloxifene: a selective estrogen receptor modulator.

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12 December 2020

Influence of tamoxifen and its N-desmethyl and 4-hydroxy metabolites on rat liver microsomal enzymes

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12 December 2020

Tamoxifen and toremifene in breast cancer: comparison of safety and efficacy

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12 December 2020

Effects of tamoxifen on bone mineral density in postmenopausal women with breast cancer

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12 December 2020

Pharmacokinetics of toremifene and its metabolites in patients with advanced breast cancer

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12 December 2020

Clinical pharmacokinetics of drugs used in the treatment of breast cancer

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12 December 2020

Tamoxifen metabolic patterns within a glioma patient population treated with high-dose tamoxifen

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12 December 2020

Tamoxifen. A reappraisal of its pharmacodynamic and pharmacokinetic properties, and therapeutic use.

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12 December 2020

Distribution of 4-hydroxy-N-desmethyltamoxifen and other tamoxifen metabolites in human biological fluids during tamoxifen treatment

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12 December 2020

Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study

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12 December 2020

Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women

1 reference

12 December 2020

Antiatherogenic effects of adjuvant antiestrogens: a randomized trial comparing the effects of tamoxifen and toremifene on plasma lipid levels in postmenopausal women with node-positive breast cancer

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12 December 2020

The distribution and metabolism of 14C-labelled tamoxifen in spayed female mice

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12 December 2020

Pharmacokinetics of toremifene

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12 December 2020

Raloxifene hydrochloride

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12 December 2020

Pharmacokinetics of raloxifene and its clinical application

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12 December 2020

Phase I study of the tolerance and pharmacokinetics of toremifene in patients with cancer

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12 December 2020

The bioavailability of Tamoplex (tamoxifen). Part 2. A single dose cross-over study in healthy male volunteers

1 reference

12 December 2020

Analysis of cross-resistance of the selective estrogen receptor modulators arzoxifene (LY353381) and LY117018 in tamoxifen-stimulated breast cancer xenografts.

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12 December 2020

Tamoxifen and metabolites in MCF7 cells: correlation between binding to estrogen receptor and inhibition of cell growth.

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12 December 2020

Identification and biological activity of tamoxifen metabolites in human serum

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12 December 2020

Distribution of tamoxifen and its metabolites in rat and human tissues during steady-state treatment.

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12 December 2020

10.2165/00003088-200342040-00004

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DOI

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Dimensions Publication ID

31 July 2017

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