(Q34185881)

31 July 2017

title

A structural model of EmrE, a multi-drug transporter from Escherichia coli (English)

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31 July 2017

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Kay-Eberhard Gottschalk

1

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31 July 2017

Misha Soskine

2

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31 July 2017

Shimon Schuldiner

3

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31 July 2017

Horst Kessler

4

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31 July 2017

language of work or name

English

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publication date

1 June 2004

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31 July 2017

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31 July 2017

volume

86

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31 July 2017

issue

6

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31 July 2017

page(s)

3335-3348

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Structure prediction of small transmembrane helix bundles

31 July 2017

cites work

1 reference

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Structure of the multidrug resistance efflux transporter EmrE from Escherichia coli

5 July 2018

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Three-dimensional structure of the bacterial multidrug transporter EmrE shows it is an asymmetric homodimer

5 July 2018

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Conformational changes in the multidrug transporter EmrE associated with substrate binding

5 July 2018

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5 July 2018

Bacterial ion channels

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Structure and mechanism of the lactose permease of Escherichia coli

5 July 2018

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Position-dependence of stabilizing polar interactions of asparagine in transmembrane helical bundles

5 July 2018

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Characterization of an archaeal multidrug transporter with a unique amino acid composition

5 July 2018

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5 July 2018

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Crystal structure of bacterial multidrug efflux transporter AcrB

5 July 2018

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Crosslinking of membrane-embedded cysteines reveals contact points in the EmrE oligomer

5 July 2018

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A large iris-like expansion of a mechanosensitive channel protein induced by membrane tension

5 July 2018

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The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism

5 July 2018

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Mechanism of the F(1)F(0)-type ATP synthase, a biological rotary motor

5 July 2018

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Structure of the interferon-receptor complex determined by distance constraints from double-mutant cycles and flexible docking

5 July 2018

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Mapping the energy surface of transmembrane helix-helix interactions

5 July 2018

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Functional analysis of novel multidrug transporters from human pathogens

5 July 2018

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RETRACTED: Structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding cassette (ABC) transporters

5 July 2018

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A new method to model membrane protein structure based on silent amino acid substitutions.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

Small is mighty: EmrE, a multidrug transporter as an experimental paradigm

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

SMR-type multidrug resistance pumps.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

Precious things come in little packages.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

The projection structure of EmrE, a proton-linked multidrug transporter from Escherichia coli, at 7 A resolution

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

Polar side chains drive the association of model transmembrane peptides

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

Helical membrane protein folding, stability, and evolution

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

A common binding site for substrates and protons in EmrE, an ion-coupled multidrug transporter.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

5 July 2018

Antibiotic efflux pumps

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

Recursive use of evolutionary conservation data in molecular modeling of membrane proteins A model of the multidrug H+ antiporter emrE.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

A membrane-embedded glutamate is required for ligand binding to the multidrug transporter EmrE

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

Evolutionary relationship between K(+) channels and symporters

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

Defining the transmembrane helix of M2 protein from influenza A by molecular dynamics simulations in a lipid bilayer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

NMR investigation of the multidrug transporter EmrE, an integral membrane protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

Structure-based prediction of the stability of transmembrane helix-helix interactions: the sequence dependence of glycophorin A dimerization

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

A transmembrane helix dimer: structure and implications

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

Proton-dependent multidrug efflux systems

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

Improved prediction for the structure of the dimeric transmembrane domain of glycophorin A obtained through global searching

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

Negative dominance studies demonstrate the oligomeric structure of EmrE, a multidrug antiporter from Escherichia coli.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

The SMR family: a novel family of multidrug efflux proteins involved with the efflux of lipophilic drugs.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

Prevention of drug access to bacterial targets: permeability barriers and active efflux

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

Structure and stability of membrane proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

Proposed Knobs-Into-Holes Packing for Several Membrane Proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

A simple method for modeling transmembrane helix oligomers

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

Structure of the substrate binding pocket of the multidrug transporter EmrE: site-directed spin labeling of transmembrane segment 1.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

An amino acid cluster around the essential Glu-14 is part of the substrate- and proton-binding domain of EmrE, a multidrug transporter from Escherichia coli.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

Computation and mutagenesis suggest a right-handed structure for the synaptobrevin transmembrane dimer

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

A single carboxyl mutant of the multidrug transporter EmrE is fully functional

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

A model for coupling of H(+) and substrate fluxes based on "time-sharing" of a common binding site

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

An essential glutamyl residue in EmrE, a multidrug antiporter from Escherichia coli

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

Interaction of transmembrane helices by a knobs-into-holes packing characteristic of soluble coiled coils.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

Ion channels formed by HIV-1 Vpu: a modelling and simulation study

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

Determining the secondary structure and orientation of EmrE, a multi-drug transporter, indicates a transmembrane four-helix bundle.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

In VitroMonomer Swapping in EmrE, a Multidrug Transporter fromEscherichia coli,Reveals That the Oligomer Is the Functional Unit

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304243

Molecular dynamics simulations of the ErbB-2 transmembrane domain within an explicit membrane environment: comparison with vacuum simulations

9 December 2018

1 reference

12 December 2020

Scanning Cysteine Accessibility of EmrE, an H+-coupled Multidrug Transporter fromEscherichia coli, Reveals a Hydrophobic Pathway for Solutes

1 reference

12 December 2020

Membrane protein folding and oligomerization: the two-stage model

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12 December 2020

The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin

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12 December 2020

Refolding of bacteriorhodopsin in lipid bilayers. A thermodynamically controlled two-stage process

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12 December 2020

Computational searching and mutagenesis suggest a structure for the pentameric transmembrane domain of phospholamban

1 reference

12 December 2020

EmrE, an Escherichia coli 12-kDa multidrug transporter, exchanges toxic cations and H+ and is soluble in organic solvents

1 reference

12 December 2020

Identification of residues in the translocation pathway of EmrE, a multidrug antiporter from Escherichia coli

1 reference

12 December 2020

An automated approach for clustering an ensemble of NMR-derived protein structures into conformationally related subfamilies

1 reference

12 December 2020

10.1529/BIOPHYSJ.103.034546

Identifiers

DOI

1 reference

31 July 2017

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31 July 2017

1 reference