(Q34186954)

31 July 2017

title

A signal transduction pathway model prototype I: From agonist to cellular endpoint (English)

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31 July 2017

Thomas J Lukas

1

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31 July 2017

language of work or name

English

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publication date

1 September 2004

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31 July 2017

number of pages

11

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inferred from page(s)

published in

Biophysical Journal

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31 July 2017

volume

87

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31 July 2017

issue

3

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31 July 2017

page(s)

1406-1416

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A signal transduction pathway model prototype II: Application to Ca2+-calmodulin signaling and myosin light chain phosphorylation

31 July 2017

cites work

1 reference

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Metabotropic receptor activation, desensitization and sequestration-II: modelling the dynamics of the pleckstrin homology domain

5 July 2018

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Kinetic analysis of receptor-activated phosphoinositide turnover

5 July 2018

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Untangling ligand induced activation and desensitization of G-protein-coupled receptors

5 July 2018

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Specificity and structural requirements of phospholipase C-beta stimulation by Rho GTPases versus G protein beta gamma dimers

5 July 2018

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Lessons from constitutively active mutants of G protein-coupled receptors

5 July 2018

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Simulations of inositol phosphate metabolism and its interaction with InsP(3)-mediated calcium release

5 July 2018

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The ligand paradox between affinity and efficacy: can you be there and not make a difference?

5 July 2018

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Computational cell biology: spatiotemporal simulation of cellular events

5 July 2018

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Modelling of simple and complex calcium oscillations. From single-cell responses to intercellular signalling.

5 July 2018

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Reciprocal regulation of capacitative and non-capacitative Ca2+ entry in A7r5 vascular smooth muscle cells: only the latter operates during receptor activation

5 July 2018

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5 July 2018

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Activity-dependent CREB phosphorylation: convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway

5 July 2018

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Detection of bradykinin B1 receptors in rat aortic smooth muscle cells.

5 July 2018

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The human B1 bradykinin receptor exhibits high ligand-independent, constitutive activity. Roles of residues in the fourth intracellular and third transmembrane domains

5 July 2018

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Control of cellular phosphatidylinositol 4,5-bisphosphate levels by adhesion signals and rho GTPases in NIH 3T3 fibroblasts involvement of both phosphatidylinositol-4-phosphate 5-kinase and phospholipase C.

5 July 2018

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An image-based model of calcium waves in differentiated neuroblastoma cells

5 July 2018

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Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase

5 July 2018

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Rapid GTP binding and hydrolysis by G(q) promoted by receptor and GTPase-activating proteins

5 July 2018

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Determination of time-dependent inositol-1,4,5-trisphosphate concentrations during calcium release in a smooth muscle cell

5 July 2018

1 reference

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Analysis of the functional coupling between calmodulin's calcium binding and peptide recognition properties

5 July 2018

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Structural basis of agonist-induced desensitization and sequestration of the P2Y2 nucleotide receptor. Consequences of truncation of the C terminus.

5 July 2018

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A mathematical model for ligand/receptor/G-protein dynamics and actin polymerization in human neutrophils.

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304549

Tyrosine-phosphorylation-dependent and rho-protein-mediated control of cellular phosphatidylinositol 4,5-bisphosphate levels

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304549

The synthesis and cellular roles of phosphatidylinositol 4,5-bisphosphate

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304549

Differential regulation of muscarinic acetylcholine receptor-sensitive polyphosphoinositide pools and consequences for signaling in human neuroblastoma cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304549

Regulation of phosphoinositide-specific phospholipase C isozymes

5 July 2018

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A role for Rho in receptor- and G protein-stimulated phospholipase C. Reduction in phosphatidylinositol 4,5-bisphosphate by Clostridium difficile toxin B.

5 July 2018

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Characteristics of the bradykinin-induced changes in intracellular calcium ion concentration of single bovine tracheal smooth muscle cells

5 July 2018

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Equations for InsP3 receptor-mediated [Ca2+]i oscillations derived from a detailed kinetic model: a Hodgkin-Huxley like formalism.

5 July 2018

1 reference

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Ca(2+)-dependent phosphorylation of myosin light chain kinase decreases the Ca2+ sensitivity of light chain phosphorylation within smooth muscle cells

5 July 2018

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Des-Arg9-bradykinin-induced increases in intracellular calcium ion concentration in single bovine tracheal smooth muscle cells

5 July 2018

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Characterization of Gq family G proteins GL1 alpha (G14 alpha), GL2 alpha (G11 alpha), and Gq alpha expressed in the baculovirus-insect cell system

5 July 2018

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Stimulation of phosphatidylinositol hydrolysis, diacylglycerol release, and gene expression in response to endothelin, a potent new agonist for fibroblasts and smooth muscle cells

5 July 2018

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Endothelin evoked Ca2+ transients and oscillations in A10 vascular smooth muscle cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304549

Minimal model for signal-induced Ca2+ oscillations and for their frequency encoding through protein phosphorylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304549

Phosphorylation of smooth myosin light chain kinase by smooth muscle Ca2+/calmodulin-dependent multifunctional protein kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304549

Endothelin receptor is coupled to phospholipase C via a pertussis toxin-insensitive guanine nucleotide-binding regulatory protein in vascular smooth muscle cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304549

Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304549

Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304549

Metabotropic receptor activation, desensitization and sequestration-I: modelling calcium and inositol 1,4,5-trisphosphate dynamics following receptor activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304549

The Database of Quantitative Cellular Signaling: management and analysis of chemical kinetic models of signaling networks.

28 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304549

A spatial focusing model for G protein signals. Regulator of G protein signaling (RGS) protien-mediated kinetic scaffolding.

28 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304549

Ca2+ activation of smooth muscle contraction: evidence for the involvement of calmodulin that is bound to the triton insoluble fraction even in the absence of Ca2+.

28 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304549

Modeling activation and desensitization of G-protein coupled receptors provides insight into ligand efficacy.

28 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304549

Mechanistic model of G-protein signal transduction. Determinants of efficacy and effect of precoupled receptors.

28 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304549

Ca2+, caldesmon, and myosin light chain kinase exchange with calmodulin.

28 October 2018

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Protein kinase and protein phosphatase expression in amyotrophic lateral sclerosis spinal cord

28 October 2018

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12 December 2020

Novel kinetics of single cell Ca2+ transients in stimulated hepatocytes and A10 cells measured using fura-2 and fluorescent videomicroscopy

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12 December 2020

Microcalorimetric investigation of the interaction of calmodulin with seminalplasmin and myosin light chain kinase

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12 December 2020

Calcium dependence of myosin light chain phosphorylation in smooth muscle cells

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12 December 2020

Restoration of the calcium binding activity of mutant calmodulins toward normal by the presence of a calmodulin binding structure

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12 December 2020

Acid pairs increase the N-terminal Ca2+ affinity of CaM by increasing the rate of Ca2+ association

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12 December 2020

Effects of myosin light chain kinase and peptides on Ca2+ exchange with the N- and C-terminal Ca2+ binding sites of calmodulin

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12 December 2020

Phosphorylation of the large subunit of myosin phosphatase and inhibition of phosphatase activity

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12 December 2020

Reductionism for biochemists: how to survive the protein jungle

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12 December 2020

Biochemistry by numbers: simulation of biochemical pathways with Gepasi 3

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12 December 2020

Characterizing the response of calcium signal transducers to generated calcium transients

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12 December 2020

Apocalmodulin binds to the myosin light chain kinase calmodulin target site

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12 December 2020

10.1529/BIOPHYSJ.103.035253

Identifiers

DOI

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31 July 2017

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31 July 2017

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