(Q34188063)

31 July 2017

title

CFTR: a cysteine at position 338 in TM6 senses a positive electrostatic potential in the pore (English)

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31 July 2017

Xuehong Liu

1

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31 July 2017

Zhi-Ren Zhang

2

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31 July 2017

Matthew D Fuller

3

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31 July 2017

Joshua Billingsley

4

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31 July 2017

Nael A McCarty

5

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31 July 2017

David C Dawson

6

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31 July 2017

language of work or name

English

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publication date

10 September 2004

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31 July 2017

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31 July 2017

volume

87

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31 July 2017

issue

6

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31 July 2017

page(s)

3826-3841

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POTENTIAL, IMPEDANCE, AND RECTIFICATION IN MEMBRANES

31 July 2017

cites work

1 reference

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5 July 2018

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A study of the kinetics of the reaction between thiol compounds and chloroacetamide

5 July 2018

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Multiple roles of cysteine in biocatalysis

5 July 2018

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Experimental pK(a) values of buried residues: analysis with continuum methods and role of water penetration

5 July 2018

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CFTR: covalent modification of cysteine-substituted channels expressed in Xenopus oocytes shows that activation is due to the opening of channels resident in the plasma membrane

5 July 2018

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CFTR: covalent and noncovalent modification suggests a role for fixed charges in anion conduction

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

What are the dielectric "constants" of proteins and how to validate electrostatic models?

5 July 2018

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S4 charges move close to residues in the pore domain during activation in a K channel

5 July 2018

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Interaction between permeation and gating in a putative pore domain mutant in the cystic fibrosis transmembrane conductance regulator

5 July 2018

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Molecular determinants of anion selectivity in the cystic fibrosis transmembrane conductance regulator chloride channel pore

5 July 2018

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The intrinsic electrostatic potential and the intermediate ring of charge in the acetylcholine receptor channel

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

Cystic fibrosis transmembrane conductance regulator. Physical basis for lyotropic anion selectivity patterns

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

Redox reagents and divalent cations alter the kinetics of cystic fibrosis transmembrane conductance regulator channel gating

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

A self-consistent, microenvironment modulated screened coulomb potential approximation to calculate pH-dependent electrostatic effects in proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

Delimiting the binding site for quaternary ammonium lidocaine derivatives in the acetylcholine receptor channel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

Non-pore lining amino acid side chains influence anion selectivity of the human CFTR Cl- channel expressed in mammalian cell lines

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

Calculations of electrostatic interactions and pKas in the active site of Escherichia coli thioredoxin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

Electrostatic evaluation of the signature motif (H/V)CX5R(S/T) in protein-tyrosine phosphatases.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

The effect of protein relaxation on charge-charge interactions and dielectric constants of proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

Cystic fibrosis transmembrane conductance regulator (CFTR) anion binding as a probe of the pore

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

Permeability of wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride channels to polyatomic anions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

Locating the anion-selectivity filter of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

Identification of cystic fibrosis transmembrane conductance regulator channel-lining residues in and flanking the M6 membrane-spanning segment.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

CFTR: the nucleotide binding folds regulate the accessibility and stability of the activated state

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

Multigrid solution of the nonlinear Poisson-Boltzmann equation and calculation of titration curves

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

Prediction of pH-dependent properties of proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

Functional roles of the nucleotide-binding folds in the activation of the cystic fibrosis transmembrane conductance regulator

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

Ionisation of cysteine residues at the termini of model alpha-helical peptides. Relevance to unusual thiol pKa values in proteins of the thioredoxin family.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

Reactivity of small thiolate anions and cysteine-25 in papain toward methyl methanethiosulfonate

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

Energetics of charge-charge interactions in proteins.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

The electrostatic properties of membranes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

Ion-channel entrances influence permeation. Net charge, size, shape, and binding considerations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

pKa's of ionizable groups in proteins: atomic detail from a continuum electrostatic model

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

How does vestibule surface charge affect ion conduction and toxin binding in a sodium channel?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

Acetylcholine receptor channel gating and conductance involve extracellular disulfide bond(s).

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

Electrostatic calculations of the pKa values of ionizable groups in bacteriorhodopsin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

Voltage-sensitive gating induced by a mutation in the fifth transmembrane domain of CFTR.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

Identification of a region of strong discrimination in the pore of CFTR.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

Cystic fibrosis-associated mutations at arginine 347 alter the pore architecture of CFTR. Evidence for disruption of a salt bridge.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

Channel-lining residues in the M3 membrane-spanning segment of the cystic fibrosis transmembrane conductance regulator.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

The determinants of pKas in proteins

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

Electrostatic tuning of Mg2+ affinity in an inward-rectifier K+ channel.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

Mutations in CFTR associated with mild-disease-form Cl- channels with altered pore properties.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

Comparison of dielectric response models for simulating electrostatic effects in proteins

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1304894

Electrostatic potential of the acetylcholine binding sites in the nicotinic receptor probed by reactions of binding-site cysteines with charged methanethiosulfonates

28 October 2018

1 reference

12 December 2020

Substituted-cysteine accessibility method

1 reference

12 December 2020

Role of surface electrostatics in the operation of a high-conductance Ca2+-activated K+ channel

1 reference

12 December 2020

Sodium channel permeation in squid axons. II: Non-independence and current-voltage relations

1 reference

12 December 2020

On the calculation of pKas in proteins

1 reference

12 December 2020

A rapid method of calculating charge-charge interaction energies in proteins

1 reference

12 December 2020

10.1529/BIOPHYSJ.104.050534

Identifiers

DOI

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31 July 2017

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31 July 2017

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