(Q34190644)

31 July 2017

title

A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion (English)

1 reference

31 July 2017

Felix Kopp

1

1 reference

31 July 2017

Christopher F Stratton

series ordinal

2

1 reference

31 July 2017

Lakshmi B Akella

series ordinal

3

1 reference

31 July 2017

Derek S Tan

series ordinal

4

1 reference

31 July 2017

publication date

11 March 2012

1 reference

31 July 2017

published in

Nature Chemical Biology

1 reference

31 July 2017

volume

8

1 reference

31 July 2017

issue

4

1 reference

31 July 2017

page(s)

358-365

1 reference

An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors

31 July 2017

cites work

1 reference

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Expanding the range of 'druggable' targets with natural product-based libraries: an academic perspective

5 July 2018

1 reference

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The exploration of macrocycles for drug discovery--an underexploited structural class

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3359144

The bound conformation of microtubule-stabilizing agents: NMR insights into the bioactive 3D structure of discodermolide and dictyostatin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3359144

The impact of natural products upon modern drug discovery.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3359144

Topography-biased compound library design: the shape of things to come?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3359144

Macrocyclization by Ring-Closing Metathesis in the Total Synthesis of Natural Products: Reaction Conditions and Limitations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3359144

Diversity-oriented synthesis: exploring the intersections between chemistry and biology

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3359144

Synthesis of a library of complex macrodiolides employing cyclodimerization of hydroxy esters

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3359144

What can a chemist learn from nature's macrocycles?--a brief, conceptual view.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3359144

Macrolactones in diversity-oriented synthesis: preparation of a pilot library and exploration of factors controlling macrocyclization

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3359144

Stereochemical diversity through cyclodimerization: synthesis of polyketide-like macrodiolides

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3359144

Molecular shape diversity of combinatorial libraries: a prerequisite for broad bioactivity.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3359144

Molecular properties that influence the oral bioavailability of drug candidates

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3359144

Highly Enantio- and Diastereoselective Hetero-Diels-Alder Reactions Catalyzed by New Chiral Tridentate Chromium(III) Catalysts

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3359144

Lowering the entropic barrier for binding conformationally flexible inhibitors to enzymes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3359144

The Tubulin-Bound Conformation of Discodermolide Derived by NMR Studies in Solution Supports a Common Pharmacophore Model for Epothilone and Discodermolide

5 July 2018

1 reference

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Asymmetric total synthesis of erythromycin. 2. Synthesis of an erythronolide A lactone system

21 January 2018

1 reference

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From rigidity to conformational flexibility: macrocyclic templates derived from ansa-steroids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.911

Synthesis of polycyclic structures by the Diels-Alder reaction of inner-outer-ring 1,3-bis(trimethylsilyloxy)dienes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.911

Catalyzed Diels-Alder reaction of alkylidene- or arylideneacetoacetates and Danishefsky's dienes with lanthanide salts aimed at selective synthesis of cis-4,5-dimethyl-2-cyclohexenone derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.911

Lanthanoids in organic synthesis. 6. Reduction of .alpha.-enones by sodium borohydride in the presence of lanthanoid chlorides: synthetic and mechanistic aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.911

Ruthenium-catalyzed oxidative cleavage of olefins to aldehydes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.911

An effective use of benzoic anhydride and its derivatives for the synthesis of carboxylic esters and lactones: a powerful and convenient mixed anhydride method promoted by basic catalysts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.911

Synthesis of macrocyclic, potential protease inhibitors using a generic scaffold

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.911

Conformational energy penalties of protein-bound ligands

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3359144

Conformational constraint in protein ligand design and the inconsistency of binding entropy

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22406518

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Ligand preorganization may be accompanied by entropic penalties in protein-ligand interactions

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22406518

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Small-molecule diversity using a skeletal transformation strategy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22406518

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCHEMBIO.911

1 reference

31 July 2017

1 reference

31 July 2017

1 reference