(Q33743418)

English

An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

29 July 2017

An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors (English)

1 reference

Europe PubMed Central

29 July 2017

author name string

Lisa A Marcaurelle

1

1 reference

Europe PubMed Central

29 July 2017

Eamon Comer

2

1 reference

Europe PubMed Central

29 July 2017

Sivaraman Dandapani

3

1 reference

Europe PubMed Central

29 July 2017

Jeremy R Duvall

4

1 reference

Europe PubMed Central

29 July 2017

Baudouin Gerard

5

1 reference

Europe PubMed Central

29 July 2017

Sarathy Kesavan

6

1 reference

Europe PubMed Central

29 July 2017

Maurice D Lee

7

1 reference

Europe PubMed Central

29 July 2017

Haibo Liu

8

1 reference

Europe PubMed Central

29 July 2017

Jason T Lowe

9

1 reference

Europe PubMed Central

29 July 2017

Jean-Charles Marie

10

1 reference

Europe PubMed Central

29 July 2017

Carol A Mulrooney

11

1 reference

Europe PubMed Central

29 July 2017

Bhaumik A Pandya

12

1 reference

Europe PubMed Central

29 July 2017

Ann Rowley

13

1 reference

Europe PubMed Central

29 July 2017

Troy D Ryba

14

1 reference

Europe PubMed Central

29 July 2017

Byung-Chul Suh

15

1 reference

Europe PubMed Central

29 July 2017

Jingqiang Wei

16

1 reference

Europe PubMed Central

29 July 2017

Damian W Young

17

1 reference

Europe PubMed Central

29 July 2017

Lakshmi B Akella

18

1 reference

Europe PubMed Central

29 July 2017

Nathan T Ross

19

1 reference

Europe PubMed Central

29 July 2017

Yan-Ling Zhang

20

1 reference

Europe PubMed Central

29 July 2017

Daniel M Fass

21

1 reference

Europe PubMed Central

29 July 2017

Surya A Reis

22

1 reference

Europe PubMed Central

29 July 2017

Wen-Ning Zhao

23

1 reference

Europe PubMed Central

29 July 2017

Stephen J Haggarty

24

1 reference

Europe PubMed Central

29 July 2017

Michelle Palmer

25

1 reference

Europe PubMed Central

29 July 2017

Michael A Foley

26

1 reference

Europe PubMed Central

29 July 2017

language of work or name

0 references

publication date

10 November 2010

1 reference

Europe PubMed Central

29 July 2017

Journal of the American Chemical Society

1 reference

Europe PubMed Central

29 July 2017

132

1 reference

Europe PubMed Central

29 July 2017

16962-16976

1 reference

Europe PubMed Central

29 July 2017

47

1 reference

Europe PubMed Central

29 July 2017

Stereochemical and skeletal diversity arising from amino propargylic alcohols

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Suppression of histone deacetylase 3 (HDAC3) enhances apoptosis induced by paclitaxel in human maxillary cancer cells in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Expanding the range of 'druggable' targets with natural product-based libraries: an academic perspective

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Formal [4+3] epoxide cascade reaction via a complementary ambiphilic pairing strategy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Chemical phylogenetics of histone deacetylases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

HDAC2 negatively regulates memory formation and synaptic plasticity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Diversity-oriented synthesis of a cytisine-inspired pyridone library leading to the discovery of novel inhibitors of Bcl-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Skeletally diverse small molecules using a build/couple/pair strategy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Synthesis of a 35-member stereoisomer library of bistramide A: evaluation of effects on actin state, cell cycle and tumor cell growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Synthesis of natural-product-like molecules with over eighty distinct scaffolds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Mechanisms and molecular probes of sirtuins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

HDAC3 impacts multiple oncogenic pathways in colon cancer cells with effects on Wnt and vitamin D signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Cu-catalyzed azide-alkyne cycloaddition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

The exploration of macrocycles for drug discovery--an underexploited structural class

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Ruthenium-catalyzed azide-alkyne cycloaddition: scope and mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Isoform-selective histone deacetylase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Chemical biology--identification of small molecule modulators of cellular activity by natural product inspired synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

The impact of natural products upon modern drug discovery.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Application of natural product-inspired diversity-oriented synthesis to drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Multivalent engagement of chromatin modifications by linked binding modules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

An approach to skeletal diversity using functional group pairing of multifunctional scaffolds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Macrocyclization by Ring-Closing Metathesis in the Total Synthesis of Natural Products: Reaction Conditions and Limitations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Total synthesis of a 28-member stereoisomer library of murisolins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Synthesis of a 10,000-membered library of molecules resembling carpanone and discovery of vesicular traffic inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Prevention of undesirable isomerization during olefin metathesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Charting biologically relevant chemical space: a structural classification of natural products (SCONP)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Ruthenium-catalyzed cycloaddition of alkynes and organic azides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Solid-supported reagents and catalysts for the preparation of large ring compounds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Discovery of novel non-peptidic ketopiperazine-based renin inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Recent applications of olefin metathesis to combinatorial chemistry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Synthesis of oxygen- and nitrogen-containing heterocycles by ring-closing metathesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Novel chimeric scaffolds to extend the exploration of receptor space: hybrid beta-D-glucose-benzoheterodiazepine structures for broad screening. Effect of amide alkylation on the course of cyclization reactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Fluorous mixture synthesis of stereoisomer libraries: total syntheses of (+)-murisolin and fifteen diastereoisomers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

The growing impact of click chemistry on drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

From discovery to the coming generation of histone deacetylase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Molecular shape diversity of combinatorial libraries: a prerequisite for broad bioactivity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Histone deacetylases (HDACs): characterization of the classical HDAC family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Deacetylase enzymes: biological functions and the use of small-molecule inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

A novel formalism to characterize the degree of unsaturation of organic molecules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Chemistry, Biology, and Medicine of the Glycopeptide Antibiotics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

21 June 2018

Practical asymmetric synthesis of β-hydroxy γ-amino acids via complimentary aldol reactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

30 October 2018

Escape from flatland: increasing saturation as an approach to improving clinical success.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

30 October 2018

Accessing skeletal diversity using catalyst control: formation of n and n + 1 macrocyclic triazole rings

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

30 October 2018

Gold(I)-catalyzed coupling reactions for the synthesis of diverse small molecules using the build/couple/pair strategy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

30 October 2018

Large scale preparation of silicon-functionalized SynPhase Polystyrene lanterns for solid-phase synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

30 October 2018

Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: implications for therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

30 October 2018

Synthesis of all 16 stereoisomers of pinesaw fly sex pheromones--tools and tactics for solving problems in fluorous mixture synthesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

30 October 2018

Boron-mediated aldol reaction of carboxylic esters: complementary anti- and syn-selective asymmetric aldol reactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

30 October 2018

Use of biomimetic diversity-oriented synthesis to discover galanthamine-like molecules with biological properties beyond those of the natural product

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

30 October 2018

Conformational energy penalties of protein-bound ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3004530

30 October 2018

Synthesis of cyclic peptidomimetics from aldol building blocks

1 reference

https://pubmed.ncbi.nlm.nih.gov/21067169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis of Medium-Sized Rings by the Ring-Closing Metathesis Reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/21067169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Total synthesis and structural assignment of spongidepsin through a stereodivergent ring-closing-metathesis strategy

1 reference

https://pubmed.ncbi.nlm.nih.gov/21067169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A convergent approach to cyclopeptide alkaloids: total synthesis of sanjoinine G1

1 reference

https://pubmed.ncbi.nlm.nih.gov/21067169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metathesis reactions in total synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21067169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Boron-mediated aldol reaction of carboxylic esters

1 reference

https://pubmed.ncbi.nlm.nih.gov/21067169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular diversity by design

1 reference

https://pubmed.ncbi.nlm.nih.gov/21067169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A boronic ester annulation strategy for diversity-oriented organic synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21067169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An Oligomer-Based Approach to Skeletal Diversity in Small-Molecule Synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21067169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ruthenium-catalyzed cycloaddition of aryl azides and alkynes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21067169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship of stereochemical and skeletal diversity of small molecules to cellular measurement space

1 reference

https://pubmed.ncbi.nlm.nih.gov/21067169

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JA105119R

1 reference

Europe PubMed Central

29 July 2017

1 reference

Europe PubMed Central

29 July 2017

1 reference

Europe PubMed Central

29 July 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q33743418&oldid=1534277245"