(Q33974618)

30 July 2017

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title

The growing impact of click chemistry on drug discovery (English)

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30 July 2017

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2

K Barry Sharpless

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30 July 2017

1

Hartmuth C Kolb

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30 July 2017

1 December 2003

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30 July 2017

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30 July 2017

8

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30 July 2017

1128-1137

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30 July 2017

24

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The properties of known drugs. 1. Molecular frameworks

30 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

The art and practice of structure-based drug design: A molecular modeling perspective

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Natural products as sources of new drugs over the period 1981-2002.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Recent natural products based drug development: a pharmaceutical industry perspective

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Catalytic Asymmetric Hetero-Diels-Alder Reactions of Carbonyl Compounds and Imines

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Catalytic Asymmetric Dihydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Tert-butylsulfonamide. A new nitrogen source for catalytic aminohydroxylation and aziridination of olefins

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

A potent and highly selective inhibitor of human alpha-1,3-fucosyltransferase via click chemistry

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Click linker: efficient and high-yielding synthesis of a new family of SPOS resins by 1,3-dipolar cycloaddition

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Solid-phase synthesis of 1,2,3-triazoles via 1,3-dipolar cycloaddition

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Multivalent Neoglycoconjugates by Regiospecific Cycloaddition of Alkynes and Azides Using Organic-Soluble Copper Catalysts

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Enzyme action in glycoprotein synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Carbohydrate mimetics-based glycosyltransferase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Synthesis and evaluation of transition-state analogue inhibitors of alpha-1,3-fucosyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

HIV protease inhibitors: peptidomimetic drugs and future perspectives

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Self-assembling cytotoxins

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Synergism through direct covalent bonding between agents: a strategy for rational design of chemotherapeutic combinations

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Using an Enzyme's Active Site To Template Inhibitors This work was supported by the Centre National de la Recherche Scientifique and by the Ecole Polytechnique (predoctoral fellowship to R.N.). We thank Prof. Jean-Marie Lehn for stimulating discussi

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Dynamic combinatorial chemistry

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Interaction of fluorescence probes with acetylcholinesterase. Site and specificity of propidium binding

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Engineering chemical reactivity on cell surfaces through oligosaccharide biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

A chemical approach for identifying O-GlcNAc-modified proteins in cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Bioconjugation by copper(I)-catalyzed azide-alkyne [3 + 2] cycloaddition

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Cell surface labeling of Escherichia coli via copper(I)-catalyzed [3+2] cycloaddition

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Adding amino acids with novel reactivity to the genetic code of Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Chemical strategies for functional proteomics

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne [3 + 2] cycloaddition

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

DNA sequencing with chain-terminating inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Click chemistry to construct fluorescent oligonucleotides for DNA sequencing

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Detection of specific DNA sequences by fluorescence amplification: a color complementation assay

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

Synthesis of 5- and 6-hydroxymethylfluorescein phosphoramidites

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902933-7

7 January 2021

10.1016/S1359-6446(03)02933-7

Identifiers

DOI

1 reference

30 July 2017

1 reference

PubMed ID

14678739