(Q34191602)

31 July 2017

title

Otoferlin is a calcium sensor that directly regulates SNARE-mediated membrane fusion (English)

1 reference

31 July 2017

Colin P Johnson

1

0 references

Edwin Chapman

object named as

Edwin R Chapman

series ordinal

2

0 references

language of work or name

English

0 references

publication date

1 October 2010

1 reference

31 July 2017

published in

Journal of Cell Biology

1 reference

31 July 2017

volume

191

1 reference

31 July 2017

issue

1

1 reference

31 July 2017

page(s)

187-197

1 reference

Characterization of lipid binding specificities of dysferlin C2 domains reveals novel interactions with phosphoinositides

31 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2953437

Direct interaction of otoferlin with syntaxin 1A, SNAP-25, and the L-type voltage-gated calcium channel Cav1.3.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2953437

The Janus-faced nature of the C(2)B domain is fundamental for synaptotagmin-1 function.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2953437

Rab8b GTPase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2953437

Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2953437

Evidence that vesicles undergo compound fusion on the synaptic ribbon

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2953437

How does synaptotagmin trigger neurotransmitter release?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2953437

A missense mutation in the conserved C2B domain of otoferlin causes deafness in a new mouse model of DFNB9

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2953437

Synaptotagmin activates membrane fusion through a Ca2+-dependent trans interaction with phospholipids

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2953437

How synaptotagmin promotes membrane fusion.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2953437

Differential expression of otoferlin in brain, vestibular system, immature and mature cochlea of the rat

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2953437

Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2953437

Ca(2+)-synaptotagmin directly regulates t-SNARE function during reconstituted membrane fusion.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2953437

Transmitter release at the hair cell ribbon synapse

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2953437

The tandem C2 domains of synaptotagmin contain redundant Ca2+ binding sites that cooperate to engage t-SNAREs and trigger exocytosis.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2953437

Mechanisms of tryptophan fluorescence shifts in proteins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2953437

C2 domains from different Ca2+ signaling pathways display functional and mechanistic diversity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2953437

SNARE complex at the ribbon synapses of cochlear hair cells: analysis of synaptic vesicle- and synaptic membrane-associated proteins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2953437

Solution structures of the Ca2+-free and Ca2+-bound C2A domain of synaptotagmin I: does Ca2+ induce a conformational change?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2953437

SNAREpins: minimal machinery for membrane fusion

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2953437

Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2953437

Phase-locked response to low-frequency tones in single auditory nerve fibers of the squirrel monkey

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2953437

Synaptotagmin: a calcium sensor on the synaptic vesicle surface.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2953437

Fusion pore dynamics are regulated by synaptotagmin*t-SNARE interactions.

28 July 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201002089

Ca2+ regulates the interaction between synaptotagmin and syntaxin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201002089

Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201002089

Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201002089

Synaptotagmin C2B domain regulates Ca2+-triggered fusion in vitro: critical residues revealed by scanning alanine mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201002089

Otoferlin interacts with myosin VI: implications for maintenance of the basolateral synaptic structure of the inner hair cell.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201002089

Synaptotagmin-mediated bending of the target membrane is a critical step in Ca(2+)-regulated fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201002089

The transmembrane domain of syntaxin 1A is critical for cytoplasmic domain protein-protein interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201002089

Q829X, a novel mutation in the gene encoding otoferlin (OTOF), is frequently found in Spanish patients with prelingual non-syndromic hearing loss.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201002089

Substitutions in the conserved C2C domain of otoferlin cause DFNB9, a form of nonsyndromic autosomal recessive deafness

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201002089

A novel missense mutation in a C2 domain of OTOF results in autosomal recessive auditory neuropathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201002089

Reconstitution of Ca2+-regulated membrane fusion by synaptotagmin and SNAREs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201002089

OTOF encodes multiple long and short isoforms: genetic evidence that the long ones underlie recessive deafness DFNB9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.201002089

Kinetics of synaptotagmin responses to Ca2+ and assembly with the core SNARE complex onto membranes

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20921140

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Morphological differences among radial afferent fibers in the cat cochlea: an electron-microscopic study of serial sections

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20921140

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Isolated p65 protein reproduces membrane binding activity of synaptic vesicles

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20921140

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1083/JCB.201002089

1 reference

31 July 2017

1 reference

31 July 2017

1 reference