(Q34198399)

31 July 2017

title

Evolution of a signaling nexus constrained by protein interfaces and conformational States (English)

1 reference

31 July 2017

Evolution of a Signaling Nexus Constrained by Protein Interfaces and Conformational States (English)

1 reference

10.1371/JOURNAL.PCBI.1000962

DOI

https://api.crossref.org/works/10.1371/JOURNAL.PCBI.1000962

10 August 2024

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20976244

10 August 2024

genetic model

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20976244

10 August 2024

molecular model

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20976244

10 August 2024

author name string

Brenda R. S. Temple

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20976244

10 August 2024

Corbin D. Jones

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20976244

10 August 2024

Alan M. Jones

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20976244

10 August 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20976244

10 August 2024

publication date

14 October 2010

1 reference

full work available at URL

31 July 2017

https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000962&type=printable

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20976244

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20976244/?tool=EBI

10 August 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20976244

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20976244/pdf/?tool=EBI

10 August 2024

file format

Portable Document Format

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20976244

https://europepmc.org/articles/PMC2954821

10 August 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20976244

https://europepmc.org/articles/PMC2954821?pdf=render

10 August 2024

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20976244

http://dx.plos.org/10.1371/journal.pcbi.1000962

10 August 2024

1 reference

10.1371/JOURNAL.PCBI.1000962

DOI

https://api.crossref.org/works/10.1371/JOURNAL.PCBI.1000962

PLOS Computational Biology

10 August 2024

published in

1 reference

31 July 2017

volume

6

1 reference

31 July 2017

issue

10

1 reference

31 July 2017

page(s)

e1000962

1 reference

Creative Commons Attribution 4.0 International

31 July 2017

copyright license

start time

14 October 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

An epistatic ratchet constrains the direction of glucocorticoid receptor evolution

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Structural evidence for a sequential release mechanism for activation of heterotrimeric G proteins

5 July 2018

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Prediction of protein-protein interfaces on G-protein beta subunits reveals a novel phospholipase C beta2 binding domain

5 July 2018

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Turning a hobby into a job: how duplicated genes find new functions

5 July 2018

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Receptor-mediated changes at the myristoylated amino terminus of Galpha(il) proteins.

5 July 2018

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Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs

5 July 2018

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Crystal structure of an ancient protein: evolution by conformational epistasis

5 July 2018

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Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain

5 July 2018

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Functional divergence after gene duplication and sequence-structure relationship: a case study of G-protein alpha subunits.

5 July 2018

1 reference

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Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins

5 July 2018

1 reference

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Evolution of hormone-receptor complexity by molecular exploitation

5 July 2018

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A new approach to producing functional G alpha subunits yields the activated and deactivated structures of G alpha(12/13) proteins

5 July 2018

1 reference

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Functional consequences of G alpha 13 mutations that disrupt interaction with p115RhoGEF

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954821

The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA.

5 July 2018

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The Universal Protein Resource (UniProt)

5 July 2018

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Plants: the latest model system for G-protein research

5 July 2018

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5 July 2018

An overview of Ensembl

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954821

5 July 2018

1 reference

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Differential interaction of GRK2 with members of the G alpha q family

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954821

ExPASy: The proteomics server for in-depth protein knowledge and analysis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954821

Amino acids determining enzyme-substrate specificity in prokaryotic and eukaryotic protein kinases

5 July 2018

1 reference

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Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits

5 July 2018

1 reference

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Human p63RhoGEF, a novel RhoA-specific guanine nucleotide exchange factor, is localized in cardiac sarcomere

5 July 2018

1 reference

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Mapping of contact sites in complex formation between light-activated rhodopsin and transducin by covalent crosslinking: use of a chemically preactivated reagent

5 July 2018

1 reference

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Mapping of contact sites in complex formation between transducin and light-activated rhodopsin by covalent crosslinking: use of a photoactivatable reagent

5 July 2018

1 reference

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Evolutionary trace analysis of TGF-beta and related growth factors: implications for site-directed mutagenesis.

5 July 2018

1 reference

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Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954821

T-Coffee: A novel method for fast and accurate multiple sequence alignment

5 July 2018

1 reference

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The G protein subunit gene families

5 July 2018

1 reference

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Guanine nucleotide exchange factor GEF115 specifically mediates activation of Rho and serum response factor by the G protein alpha subunit Galpha13

5 July 2018

1 reference

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Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13

5 July 2018

1 reference

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p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13

5 July 2018

1 reference

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Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS

5 July 2018

1 reference

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The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools

5 July 2018

1 reference

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Crystal structure of the adenylyl cyclase activator Gsalpha

5 July 2018

1 reference

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Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis

5 July 2018

1 reference

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Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins

5 July 2018

1 reference

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Evolutionarily conserved Galphabetagamma binding surfaces support a model of the G protein-receptor complex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954821

The 2.0 A crystal structure of a heterotrimeric G protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954821

The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954821

The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954821

Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954821

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954821

Transducin-alpha C-terminal mutations prevent activation by rhodopsin: a new assay using recombinant proteins expressed in cultured cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954821

Basic local alignment search tool

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954821

Identification of effector-activating residues of Gs alpha

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954821

Evolution of the mammalian G protein alpha subunit multigene family

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954821

Signal transfer from GPCRs to G proteins: role of the G alpha N-terminal region in rhodopsin-transducin coupling.

5 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000962

Rhodopsin-transducin coupling: role of the Galpha C-terminus in nucleotide exchange catalysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000962

Using information theory to search for co-evolving residues in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000962

Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000962

Critical role of lysine 204 in switch I region of Galpha13 for regulation of p115RhoGEF and leukemia-associated RhoGEF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000962

Receptor and betagamma binding sites in the alpha subunit of the retinal G protein transducin

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000962

Extensive gene duplication in the early evolution of animals before the parazoan-eumetazoan split demonstrated by G proteins and protein tyrosine kinases from sponge and hydra

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000962

Isoform divergence of the filamin family of proteins

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954821

Evolutionary analysis of G-proteins in early metazoans: cloning of alpha- and beta-subunits from the sponge Geodia cydonium

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2954821

A novel site on the Galpha -protein that recognizes heptahelical receptors

28 October 2018

1 reference

12 December 2020

Site of G protein binding to rhodopsin mapped with synthetic peptides from the alpha subunit

1 reference

12 December 2020

Structure of the p115RhoGEF rgRGS domain-Galpha13/i1 chimera complex suggests convergent evolution of a GTPase activator

1 reference

12 December 2020

The effect of carboxyl-terminal mutagenesis of Gt alpha on rhodopsin and guanine nucleotide binding

1 reference

12 December 2020

G protein-coupled receptor kinases

1 reference

12 December 2020

Promiscuous Coupling of Receptors to Gq Class α Subunits and Effector Proteins in Pancreatic and Submandibular Gland Cells

1 reference

12 December 2020

Roles of the transducin alpha-subunit alpha4-helix/alpha4-beta6 loop in the receptor and effector interactions

1 reference

12 December 2020

10.1371/JOURNAL.PCBI.1000962

Identifiers

DOI

1 reference

journals/ploscb/TempleJJ10

31 July 2017

DBLP publication ID

1 reference

DBLP Dataset 2021-01-02

release_epdogia3brhwrkfygdwe64fcaq

28 January 2021

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/epdogia3brhwrkfygdwe64fcaq

24 November 2022

mapped directly with Wikidata item

PMC publication ID

2954821

1 reference

31 July 2017

1 reference