(Q34199980)

31 July 2017

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title

Oligopeptide inhibition of class I ribonucleotide reductases (English)

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31 July 2017

Barry S Cooperman

1

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31 July 2017

publication date

1 January 2003

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31 July 2017

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31 July 2017

volume

71

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31 July 2017

issue

2

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31 July 2017

page(s)

117-131

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Structure and function of the radical enzyme ribonucleotide reductase

31 July 2017

cites work

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Allosteric regulation of the third ribonucleotide reductase (NrdEF enzyme) from enterobacteriaceae

21 January 2018

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Ribonucleotide reductase as a chemotherapeutic target

21 January 2018

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The enzyme ribonucleotide reductase: target for antitumor and anti-HIV therapy

21 January 2018

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Mechanism-based inhibition of ribonucleotide reductases: new mechanistic considerations and promising biological applications

21 January 2018

1 reference

A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

21 January 2018

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Expression and mutation analyses of P53R2, a newly identified p53 target for DNA repair in human gastric carcinoma

21 January 2018

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Formation of the cystine between cysteine 225 and cysteine 462 from ribonucleoside diphosphate reductase is kinetically competent

21 January 2018

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Mechanism of assembly of the tyrosyl radical-dinuclear iron cluster cofactor of ribonucleotide reductase.

21 January 2018

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Thiyl radicals in ribonucleotide reductases.

21 January 2018

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Controlled protein degradation regulates ribonucleotide reductase activity in proliferating mammalian cells during the normal cell cycle and in response to DNA damage and replication blocks

21 January 2018

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A comprehensive model for the allosteric regulation of mammalian ribonucleotide reductase. Functional consequences of ATP- and dATP-induced oligomerization of the large subunit

21 January 2018

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Comprehensive model for allosteric regulation of mammalian ribonucleotide reductase: refinements and consequences

21 January 2018

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Reduction of Ribonucleotides

21 January 2018

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Cross-talk between the allosteric effector-binding sites in mouse ribonucleotide reductase

21 January 2018

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Structure of ribonucleotide reductase protein R1

21 January 2018

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Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding

21 January 2018

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Structure and function of the Escherichia coli ribonucleotide reductase protein R2

21 January 2018

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The three-dimensional structure of mammalian ribonucleotide reductase protein R2 reveals a more-accessible iron-radical site than Escherichia coli R2

21 January 2018

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Structure of Salmonella typhimurium nrdF ribonucleotide reductase in its oxidized and reduced forms

21 January 2018

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Crystal structure of the di-iron/radical protein of ribonucleotide reductase from Corynebacterium ammoniagenes

21 January 2018

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Ribonucleotide reductase inhibitors: new strategies for cancer chemotherapy

21 January 2018

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Syntheses and antitumor activities of potent inhibitors of ribonucleotide reductase: 3-amino-4-methylpyridine-2-carboxaldehyde-thiosemicarba-zone (3-AMP), 3-amino-pyridine-2-carboxaldehyde-thiosemicarbazone (3-AP) and its water-soluble prodrugs

21 January 2018

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Triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity.

21 January 2018

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Differential effects of gemcitabine on ribonucleotide pools of twenty-one solid tumour and leukaemia cell lines.

21 January 2018

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Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication

21 January 2018

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Inhibition of ribonucleotide reductase by 2'-substituted deoxycytidine analogs: possible application in AIDS treatment

21 January 2018

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Hydroxyurea to inhibit human immunodeficiency virus-1 replication

21 January 2018

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Thrombotic microangiopathy with renal failure in two patients undergoing gemcitabine chemotherapy

21 January 2018

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Specific inhibition of herpesvirus ribonucleotide reductase by a nonapeptide derived from the carboxy terminus of subunit 2.

21 January 2018

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Oligopeptides inhibit the ribonucleotide reductase of herpes simplex virus by causing subunit separation

21 January 2018

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Synthesis and inhibitory potency of peptides corresponding to the subunit 2 C-terminal region of herpes virus ribonucleotide reductases

21 January 2018

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Structure-function studies of peptides inhibiting the ribonucleotide reductase activity of herpes simplex virus type I

21 January 2018

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Inhibition of herpes simplex virus type 1 ribonucleotide reductase by substituted tetrapeptide derivatives.

21 January 2018

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Herpes simplex virus ribonucleotide reductase subunit association inhibitors: the effect and conformation of beta-alkylated aspartic acid derivatives

21 January 2018

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A solid-phase assay for the binding of peptidic subunit association inhibitors to the herpes simplex virus ribonucleotide reductase large subunit

21 January 2018

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Peptidomimetic inhibitors of herpes simplex virus ribonucleotide reductase: a new class of antiviral agents

21 January 2018

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Peptidomimetic inhibitors of herpes simplex virus ribonucleotide reductase with improved in vivo antiviral activity

21 January 2018

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A potent peptidomimetic inhibitor of HSV ribonucleotide reductase with antiviral activity in vivo

21 January 2018

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The antiviral activity of the ribonucleotide reductase inhibitor BILD 1351 SE in combination with acyclovir against HSV type-1 in cell culture

21 January 2018

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Toward a rational design of peptide inhibitors of ribonucleotide reductase: structure-function and modeling studies

21 January 2018

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NMR structure of an inhibitory R2 C-terminal peptide bound to mouse ribonucleotide reductase R1 subunit

21 January 2018

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Structure-based optimization of peptide inhibitors of mammalian ribonucleotide reductase

21 January 2018

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Affinity-driven selection of tripeptide inhibitors of ribonucleotide reductase.

21 January 2018

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Characterization of two genes encoding the Mycobacterium tuberculosis ribonucleotide reductase small subunit

21 January 2018

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Carboxyl-terminal peptides as probes for Escherichia coli ribonucleotide reductase subunit interaction: kinetic analysis of inhibition studies

21 January 2018

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Investigation of an octapeptide inhibitor of Escherichia coli ribonucleotide reductase by transferred nuclear Overhauser effect spectroscopy

21 January 2018

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Site-directed mutagenesis and deletion of the carboxyl terminus of Escherichia coli ribonucleotide reductase protein R2. Effects on catalytic activity and subunit interaction.

21 January 2018

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Ureido-based peptidomimetic inhibitor of herpes simplex virus ribonucleotide reductase: an investigation of inhibitor bioactive conformation.

21 January 2018

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A concomitant ATP-depleting strategy markedly enhances anticancer agent activity

21 January 2018

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Specific inhibition of ribonucleotide reductases by peptides corresponding to the C-terminal of their second subunit

21 January 2018

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Trimidox, an inhibitor of ribonucleotide reductase, induces apoptosis and activates caspases in HL-60 promyelocytic leukemia cells

21 January 2018

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Specific inhibition of herpesvirus ribonucleotide reductase by synthetic peptides

21 January 2018

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Ribonucleotide reductases: radical enzymes with suicidal tendencies

21 January 2018

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Formation of a free radical of the sulfenylimine type in the mouse ribonucleotide reductase reaction with 2'-azido-2'-deoxycytidine 5'-diphosphate

21 January 2018

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A phase I clinical trial of prolonged infusion of hydroxyurea in combination with hyperfractionated, accelerated, external radiation therapy in patients with advanced squamous cell cancer of the head and neck

21 January 2018

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The critical C-terminus of the small subunit of herpes simplex virus ribonucleotide reductase is mobile and conformationally similar to C-terminal peptides.

21 January 2018

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The carboxyl terminus heptapeptide of the R2 subunit of mammalian ribonucleotide reductase inhibits enzyme activity and can be used to purify the R1 subunit

21 January 2018

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R2 C-terminal peptide inhibition of mammalian and yeast ribonucleotide reductase

21 January 2018

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Synthesis and biological activity of cyclic peptide inhibitors of ribonucleotide reductase

21 January 2018

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Effects of inadequate vitamin E and/or selenium nutrition on enzymes associated with xenobiotic metabolism

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BIP.10397

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31 July 2017

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