(Q34201296)

31 July 2017

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title

Mechanism of action of St John's wort in depression : what is known? (English)

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31 July 2017

1

Veronika Butterweck

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31 July 2017

publication date

1 January 2003

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31 July 2017

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31 July 2017

volume

17

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31 July 2017

issue

8

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31 July 2017

page(s)

539-562

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The molecular biology of serotonin receptors: therapeutic implications for the interface of mood and psychosis

31 July 2017

cites work

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12 December 2020

Comparison of an extract of hypericum (LI 160) and sertraline in the treatment of depression: a double-blind, randomized pilot study

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12 December 2020

St John's wort, hypericin, and imipramine: a comparative analysis of mRNA levels in brain areas involved in HPA axis control following short-term and long-term administration in normal and stressed rats

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12 December 2020

Increased glucocorticoid receptor gene promoter activity after antidepressant treatment

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12 December 2020

Effects of antidepressants in the rat forced swimming test.

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12 December 2020

Incidence and clinical relevance of the interactions and side effects of Hypericum preparations

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12 December 2020

Binding of typical and atypical antipsychotic drugs to multiple neurotransmitter receptors

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12 December 2020

Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic AMP-generating system in limbic forebrain

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12 December 2020

Controlled clinical trials of hypericum extracts in depressed patients--an overview

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12 December 2020

Development of β-adrenergic receptor subsensitivity by antidepressants

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12 December 2020

Effect of acute administration of hypericum perforatum-CO2 extract on dopamine and serotonin release in the rat central nervous system

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12 December 2020

The effects of antihistamines in a modified behavioral despair test

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12 December 2020

Flavonoids from Hypericum perforatum show antidepressant activity in the forced swimming test

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12 December 2020

Long-term antidepressant administration alters corticotropin-releasing hormone, tyrosine hydroxylase, and mineralocorticoid receptor gene expression in rat brain. Therapeutic implications

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12 December 2020

St. John's wort extract Ze 117 (Hypericum perforatum) inhibits norepinephrine and serotonin uptake into rat brain slices and reduces 3-adrenoceptor numbers on cultured rat brain cells

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12 December 2020

Hyperforin, a major antidepressant constituent of St. John's Wort, inhibits serotonin uptake by elevating free intracellular Na+1.

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12 December 2020

Hyperforin as a possible antidepressant component of hypericum extracts

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12 December 2020

Animal models of depression: an overview

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12 December 2020

Animal behavioural studies in the evaluation of antidepressant drugs

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12 December 2020

Neurobiological mechanisms involved in antidepressant therapies

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12 December 2020

In situ hybridization analysis of vasopressin gene transcription in the paraventricular and supraoptic nuclei of the rat: regulation by stress and glucocorticoids

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12 December 2020

A.E. Bennett Research Award. Regulation of serotonin1A, glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus: implications for the neurobiology of depression

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12 December 2020

Open field behavior of rats reared in different social conditions: the effects of stress and imipramine.

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12 December 2020

Role of serotonin in depression

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12 December 2020

Long-term effects of St. John's wort and hypericin on monoamine levels in rat hypothalamus and hippocampus

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12 December 2020

Putative neurotransmitters in the brain: selective neuronal uptake, subcellular localization, and interactions with centrally acting drugs

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12 December 2020

Further characterization of the behavioral despair test in mice: positive effects of convulsants.

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12 December 2020

Serotonin uptake and serotonin uptake inhibition

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12 December 2020

Neurochemical studies with St. John's wort in vitro

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12 December 2020

Equivalence of St John's wort extract (Ze 117) and fluoxetine: a randomized, controlled study in mild-moderate depression.

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12 December 2020

Inhibition of MAO by fractions and constituents of hypericum extract.

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12 December 2020

5HT1A receptors and pharmacotherapy. Is serotonin receptor down-regulation linked to the mechanism of action of antidepressant drugs?

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12 December 2020

In vitro receptor binding and enzyme inhibition by Hypericum perforatum extract

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12 December 2020

Effects of the total extract and fractions of Hypericum perforatum in animal assays for antidepressant activity

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12 December 2020

The validity of animal models of depression

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12 December 2020

Efficacy of an Hypericum perforatum (St. John's wort) extract in preventing and reverting a condition of escape deficit in rats

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12 December 2020

Reversal of helpless behavior by serotonin uptake blockers in rats.

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12 December 2020

Inhibition of MAO and COMT by hypericum extracts and hypericin.

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12 December 2020

Inhibition of synaptosomal uptake of 3H-L-glutamate and 3H-GABA by hyperforin, a major constituent of St. John's Wort: the role of amiloride sensitive sodium conductive pathways

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12 December 2020

Pharmacological profile of hypericum extract. Effect on serotonin uptake by postsynaptic receptors

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12 December 2020

Modulation of cytokine expression by hypericum extract

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12 December 2020

Novel strategies for pharmacotherapy of depression

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12 December 2020

Inhibition of substance P-induced cytokine synthesis by St. John's wort extracts

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12 December 2020

Hypericum perforatum L. extract does not inhibit 5-HT transporter in rat brain cortex

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12 December 2020

The future of antidepressants

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12 December 2020

Effects of Hypericum perforatum extract on ethanol intake, and on behavioral despair: a search for the neurochemical systems involved

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12 December 2020

Adhyperforin as a contributor to the effect of Hypericum perforatum L. in biochemical models of antidepressant activity

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12 December 2020

Effects of long-term administration of antidepressants and neuroleptics on receptors in the central nervous system

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12 December 2020

Hyperforin attenuates various ionic conductance mechanisms in the isolated hippocampal neurons of rat

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12 December 2020

Biochemical mechanisms of action of Hypericum LI 160 in glial and neuronal cells: inhibition of neurotransmitter uptake and stimulation of extracellular signal regulated protein kinase

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12 December 2020

Antidepressants and hypothalamic-pituitary-adrenocortical regulation

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12 December 2020

Effects of inescapable shock upon subsequent escape and avoidance responding

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12 December 2020

Stress and antidepressant effects on hippocampal and cortical 5-HT1A and 5-HT2 receptors and transport sites for serotonin

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12 December 2020

Behavioural despair in rats: A new model sensitive to antidepressant treatments

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12 December 2020

Effect of the Hypericum perforatum extract on serotonin turnover in the mouse brain

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12 December 2020

Natural polyphenols (vegetable tannins) as drugs: possible modes of action

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12 December 2020

Screen of receptor and uptake-site activity of hypericin component of St. John's wort reveals sigma receptor binding

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12 December 2020

Clinical investigation of the antidepressant effectiveness of hypericum

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12 December 2020

Psychosocial stress in tree shrews: clomipramine counteracts behavioral and endocrine changes

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12 December 2020

The paraventricular nucleus of the hypothalamus and the functional neuroanatomy of visceromotor responses to stress

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12 December 2020

St. John's wort in mild to moderate depression: the relevance of hyperforin for the clinical efficacy

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12 December 2020

In vitro receptor screening of pure constituents of St. John's wort reveals novel interactions with a number of GPCRs

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12 December 2020

A study of the antidepressant activity of Hypericum perforatum on animal models

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12 December 2020

Chronic fluoxetine treatment upregulates 5-HT uptake sites and 5-HT2 receptors in rat brain: an autoradiographic study

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12 December 2020

Non-specificity of “behavioral despair” as an animal model of depression

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12 December 2020

Depression: a new animal model sensitive to antidepressant treatments

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12 December 2020

Hyperforin represents the neurotransmitter reuptake inhibiting constituent of hypericum extract

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12 December 2020

Clinical and biochemical manifestations of depression. Relation to the neurobiology of stress (1)

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12 December 2020

5-Hydroxytryptamine2 and beta-adrenergic receptor regulation in rat brain following chronic treatment with desipramine and fluoxetine alone and in combination.

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12 December 2020

Current advances and trends in the treatment of depression

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12 December 2020

Receptor sensitivity and the mechanism of action of antidepressant treatment. Implications for the etiology and therapy of depression

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12 December 2020

Biologically active and other chemical constituents of the herb of Hypericum perforatum L.

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12 December 2020

The antidepressants fluoxetine, idazoxan and phenelzine alter corticotropin-releasing hormone and tyrosine hydroxylase mRNA levels in rat brain: therapeutic implications

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12 December 2020

Effects of long-term administration of hypericum extracts on the affinity and density of the central serotonergic 5-HT1 A and 5-HT2 A receptors

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12 December 2020

Testing the antidepressant effects of Hypericum species on animal models

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12 December 2020

Dual modulation of striatal acetylcholine release by hyperforin, a constituent of St. John's wort

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12 December 2020

Effect of Hypericum perforatum (St John's wort) in major depressive disorder: a randomized controlled trial

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12 December 2020

In vivo neurotransmitter release in the locus coeruleus--effects of hyperforin, inescapable shock and fear

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12 December 2020

Hyperforin--antidepressant activity by a novel mechanism of action

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12 December 2020

The effects of extracts from St. John's Wort and Kava Kava on brain neurotransmitter levels in the mouse

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12 December 2020

Effects of Hypericum perforatum on levels of 5-hydroxytryptamine, noradrenaline and dopamine in the cortex, diencephalon and brainstem of the rat.

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12 December 2020

Comparison of St John's wort and imipramine for treating depression: randomised controlled trial

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12 December 2020

Modulation of ion channels in rat neurons by the constituents of Hypericum perforatum.

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12 December 2020

Antidepressants: past, present and future

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12 December 2020

Inhibition of monoamine oxidase by hypericin

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12 December 2020

Effects of antidepressants and anticholinergics in a mouse “behavioral despair” test

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12 December 2020

Pharmacological and endocrine effects of Hypericum perforatum and hypericin after repeated treatment

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12 December 2020

The role of corticotropin-releasing hormone in the pathogenesis of Cushing's disease, anorexia nervosa, alcoholism, affective disorders and dementia

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12 December 2020

The effect of monoamine oxidase inhibitors compared with classical tricyclic antidepressants on learned helplessness paradigm.

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12 December 2020

Effect of chronic administration of antidepressant drugs on 5-HT2-mediated behavior in the rat following noradrenergic or serotonergic denervation

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12 December 2020

Neuroendocrine evidence for dopaminergic actions of hypericum extract (LI 160) in healthy volunteers

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12 December 2020

Researching the antidepressant actions of Hypericum perforatum (St. John's wort) in animals and man.

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12 December 2020

Increased numbers of corticotropin-releasing hormone expressing neurons in the hypothalamic paraventricular nucleus of depressed patients

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12 December 2020

Assessing antidepressant activity in rodents: recent developments and future needs

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12 December 2020

Kinetics of serotonin accumulation into slices from rat brain: relationship to catecholamine uptake

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12 December 2020

Synaptic effects of antidepressants

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12 December 2020

Do antidepressants stabilize mood through actions on the hypothalamic-pituitary-adrenocortical system?

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12 December 2020

St John's wort for depression--an overview and meta-analysis of randomised clinical trials

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12 December 2020

Solubilized hypericin and pseudohypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test

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12 December 2020

Hyperforin modulates gating of P-type Ca2+ current in cerebellar Purkinje neurons

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12 December 2020

Hypericum extract versus imipramine or placebo in patients with moderate depression: randomised multicentre study of treatment for eight weeks

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12 December 2020

Oral bioavailability of hyperforin from hypericum extracts in rats and human volunteers

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12 December 2020

Antidepressant activity of hypericum perforatum and hyperforin: the neglected possibility

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12 December 2020

Inhibition of benzodiazepine binding in vitro by amentoflavone, a constituent of various species of Hypericum

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12 December 2020

Repeated immobilization stress alters tyrosine hydroxylase, corticotropin-releasing hormone and corticosteroid receptor messenger ribonucleic Acid levels in rat brain

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12 December 2020

Evaluation of synaptosomal uptake inhibition of most relevant constituents of St. John's wort

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12 December 2020

Catecholamine uptake by synaptosomes from rat brain. Structure-activity relationships of drugs with differential effects on dopamine and norepinephrine neurons

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12 December 2020

Comparison of hypericum extracts with imipramine and fluoxetine in animal models of depression and alcoholism

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12 December 2020

Hyperforin enhances the extracellular concentrations of catecholamines, serotonin and glutamate in the rat locus coeruleus

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12 December 2020

Acute effects of LI 160 (extract of Hypericum perforatum, St John's wort) and two of its constituents on neuroendocrine responses in the rat

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12 December 2020

Effects of hypericum extract (LI 160) in biochemical models of antidepressant activity

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12 December 2020

In vitro binding studies with two hypericum perforatum extracts--hyperforin, hypericin and biapigenin--on 5-HT6, 5-HT7, GABA(A)/benzodiazepine, sigma, NPY-Y1/Y2 receptors and dopamine transporters

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12 December 2020

Effects of standardized extracts of St. John's wort on the single-unit activity of serotonergic dorsal Raphe neurons in awake cats: comparisons with fluoxetine and sertraline

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12 December 2020

Efficacy and tolerability of St. John's wort extract LI 160 versus imipramine in patients with severe depressive episodes according to ICD-10

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12 December 2020

Phenolic compounds from Hypericum perforatum

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12 December 2020

Extracts and constituents of Hypericum perforatum inhibit the binding of various ligands to recombinant receptors expressed with the Semliki Forest virus system

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12 December 2020

Acute and chronic actions of a dry methanolic extract of Hypericum perforatum and a hyperforin-rich extract on dopaminergic and serotonergic neurones in rat nucleus accumbens

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12 December 2020

Specificity of the learned helplessness model of depression.

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12 December 2020

Mode of action of antidepressant drugs

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12 December 2020

Effectiveness of St John's wort in major depression: a randomized controlled trial

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12 December 2020

Neurotransmitter regulation of anterior pituitary hormones

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12 December 2020

Neurotransmitter transporters: recent progress

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12 December 2020

High affinity of the naturally-occurring biflavonoid, amentoflavon, to brain benzodiazepine receptors in vitro

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12 December 2020

10.2165/00023210-200317080-00001

Identifiers

DOI

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Dimensions Publication ID

31 July 2017

1049529124

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