(Q34201997)

31 July 2017

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title

Neuronal life and death: an essential role for the p53 family (English)

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31 July 2017

Miller FD

1

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31 July 2017

Pozniak CD

series ordinal

2

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31 July 2017

Walsh GS

series ordinal

3

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31 July 2017

language of work or name

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1 October 2000

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Cell Death & Differentiation

31 July 2017

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31 July 2017

7

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31 July 2017

10

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31 July 2017

880-888

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4400736

31 July 2017

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High-frequency developmental abnormalities in p53-deficient mice.

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Requirement for a functional Rb-1 gene in murine development

21 January 2018

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Effects of an Rb mutation in the mouse

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation

21 January 2018

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A critical temporal requirement for the retinoblastoma protein family during neuronal determination

21 January 2018

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p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.

21 January 2018

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Mitochondria and apoptosis

21 January 2018

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Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.

21 January 2018

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Apaf1 is required for mitochondrial pathways of apoptosis and brain development

21 January 2018

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Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development

21 January 2018

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Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

21 January 2018

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Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Adenovirus-mediated gene transfer of the tumor suppressor, p53, induces apoptosis in postmitotic neurons

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Signal transduction by the neurotrophin receptors

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Neurotrophin signal transduction in the nervous system

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene.

21 January 2018

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Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Sympathetic neuron survival and proliferation are prolonged by loss of p53 and neurofibromin

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

p53 is essential for developmental neuron death as regulated by the TrkA and p75 neurotrophin receptors

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

BAX is required for neuronal death after trophic factor deprivation and during development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

The small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Role of apoptosis signal-regulating kinase in regulation of the c-Jun N-terminal kinase pathway and apoptosis in sympathetic neurons

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis

21 January 2018

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21 January 2018

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Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

p73 is a simian [correction of human] p53-related protein that can induce apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Structure, function and regulation of p63 and p73.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

An anti-apoptotic role for the p53 family member, p73, during developmental neuron death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

p53 induction is associated with neuronal damage in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Status epilepticus induces p53 sequence-specific DNA binding in mature rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Induction of tumor suppressor p53 and DNA fragmentation in organotypic hippocampal cultures following excitotoxin treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Roles of p53, c-Myc, Bcl-2, Bax and caspases in glutamate-induced neuronal apoptosis and the possible neuroprotective mechanism of basic fibroblast growth factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Induction of tumour-suppressor phosphoprotein p53 in the apoptosis of cultured rat cerebellar neurones triggered by excitatory amino acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Excitotoxic lesion of rat brain with quinolinic acid induces expression of p53 messenger RNA and protein and p53-inducible genes Bax and Gadd-45 in brain areas showing DNA fragmentation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

The tumor suppressor p53 and its response gene p21WAF1/Cip1 are not markers of neuronal death following transient global cerebral ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Hippocampal Myc and p53 expression following transient global ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Activation of p53 and its target genes p21(WAF1/Cip1) and PAG608/Wig-1 in ischemic preconditioning.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

p53-immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Granule cell apoptosis and protein expression in hippocampal dentate gyrus after forebrain ischemia in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Apoptosis and protein expression after focal cerebral ischemia in rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Increase in p53 protein expression following cortical infarction in the spontaneously hypertensive rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Hypoxia-induced apoptosis: effect of hypoxic severity and role of p53 in neuronal cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

The tumor-suppressor gene, p53, is induced in injured brain regions following experimental traumatic brain injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Apoptosis and expression of p53 response proteins and cyclin D1 after cortical impact in rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Tumor suppressor p53 induction and DNA damage in hippocampal granule cells after adrenalectomy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

The involvement of p53 in dopamine-induced apoptosis of cerebellar granule neurons and leukemic cells overexpressing p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Involvement of p53 in DNA strand break-induced apoptosis in postmitotic CNS neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Evidence for involvement of Bax and p53, but not caspases, in radiation-induced cell death of cultured postnatal hippocampal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Cerebellar degeneration caused by high-dose cytosine arabinoside: a clinicopathological study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Chemotherapeutic neuropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Cyclin-dependent kinases participate in death of neurons evoked by DNA-damaging agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

A new component of the transcription factor DRTF1/E2F.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Cell cycle. Piecing together the p53 puzzle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Oxidative stress induced by glutamate receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Role of reactive oxygen species and p53 in chromium(VI)-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Changes of p53 in the brains of patients with Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Mitochondria, free radicals, and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Glutamate, excitotoxicity and amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Bioenergetics in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Oxidative stress hypothesis in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Behavioral alterations associated with apoptosis and down-regulation of presenilin 1 in the brains of p53-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Extracellular deposition of beta-amyloid upon p53-dependent neuronal cell death in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Induction of neuronal differentiation by p73 in a neuroblastoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

Apoptosis and the cell cycle: the p53 connection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

A subset of p53-deficient embryos exhibit exencephaly

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

p53 expression induces apoptosis in hippocampal pyramidal neuron cultures.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

Evidence for p53-mediated modulation of neuronal viability.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

Role of the Jun kinase pathway in the regulation of c-Jun expression and apoptosis in sympathetic neurons.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

Ras regulates sympathetic neuron survival by suppressing the p53-mediated cell death pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

Cyclin dependent kinase inhibitors and dominant negative cyclin dependent kinase 4 and 6 promote survival of NGF-deprived sympathetic neurons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell death.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

Nuclear accumulation of p53 protein following kainic acid-induced seizures.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

Attenuation of p53 expression protects against focal ischemic damage in transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

Expression of cell death-associated phospho-c-Jun and p53-activated gene 608 in hippocampal CA1 neurons following global ischemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

Photochemical brain injury in rats triggers DNA fragmentation, p53 and HSP72

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

p53-deficient mice are protected against adrenalectomy-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

The role of free radicals and p53 in neuron apoptosis in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

Cytosine arabinoside kills postmitotic neurons in a fashion resembling trophic factor deprivation: evidence that a deoxycytidine-dependent process may be required for nerve growth factor signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

Cytosine arabinoside kills postmitotic neurons: evidence that deoxycytidine may have a role in neuronal survival that is independent of DNA synthesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

Involvement of retinoblastoma family members and E2F/DP complexes in the death of neurons evoked by DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

G1/S cell cycle blockers and inhibitors of cyclin-dependent kinases suppress camptothecin-induced neuronal apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

Bax involvement in p53-mediated neuronal cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

Contribution of p53-dependent caspase activation to neuronal cell death declines with neuronal maturation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

A role for MAPK/ERK in sympathetic neuron survival: protection against a p53-dependent, JNK-independent induction of apoptosis by cytosine arabinoside.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

DNA strand breaks induced by sustained glutamate excitotoxicity in primary neuronal cultures.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

Nitric oxide, superoxide and peroxynitrite: putative mediators of NMDA-induced cell death in cerebellar granule cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

Apoptotic cell death occurs in hippocampal neurons cultured in a high oxygen atmosphere

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

Exposure to hydrogen peroxide induces cell death via apoptosis in cultured rat cortical neurons.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

Epidermal growth factor prevents oxygen-triggered apoptosis and induces sustained signalling in cultured rat cerebral cortical neurons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

Cu,Zn-superoxide dismutase-dependent apoptosis induced by nitric oxide in neuronal cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

The amyloid beta peptide abeta (25-35) induces apoptosis independent of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400736

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4400736

1 reference

Dimensions Publication ID

31 July 2017

0 references

1 reference