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p53 Isoforms: An Intracellular Microprocessor?
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Europe PubMed Central
PMCID
3135639
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21779513%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
title
p53 Isoforms: An Intracellular Microprocessor?
(English)
1 reference
stated in
Europe PubMed Central
PMCID
3135639
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21779513%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
main subject
microprocessor
0 references
author
Jean-Christophe Bourdon
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMCID
3135639
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21779513%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
author name string
Marie P Khoury
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
3135639
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21779513%20AND%20SRC:MED&resulttype=core&format=json
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8 February 2020
publication date
1 April 2011
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Europe PubMed Central
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3135639
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21779513%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
published in
Genes & Cancer
1 reference
stated in
Europe PubMed Central
PMCID
3135639
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21779513%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
volume
2
1 reference
stated in
Europe PubMed Central
PMCID
3135639
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21779513%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
issue
4
1 reference
stated in
Europe PubMed Central
PMCID
3135639
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21779513%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
page(s)
453-465
1 reference
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Europe PubMed Central
PMCID
3135639
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21779513%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
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TAp73 knockout shows genomic instability with infertility and tumor suppressor functions
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Small molecular weight variants of p53 are expressed in human melanoma cells and are induced by the DNA-damaging agent cisplatin.
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Expression levels of p53 and p73 isoforms in stage I and stage III ovarian cancer
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Identification of a novel Bcl-2 promoter region that counteracts in a p53-dependent manner the inhibitory P2 region.
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p53FamTaG: a database resource of human p53, p63 and p73 direct target genes combining in silico prediction and microarray data
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p63 induces key target genes required for epidermal morphogenesis
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5 July 2018
Transcriptional programs regulated by p63 in normal epithelium and tumors
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5 July 2018
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
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5 July 2018
Expression of p53 isoforms in squamous cell carcinoma of the head and neck
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5 July 2018
Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells
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5 July 2018
p63 protects the female germ line during meiotic arrest
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5 July 2018
Expression of p53 and p53/47 are controlled by alternative mechanisms of messenger RNA translation initiation
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5 July 2018
The identification of an internal ribosomal entry site in the 5'-untranslated region of p53 mRNA provides a novel mechanism for the regulation of its translation following DNA damage
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5 July 2018
p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress.
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5 July 2018
Two internal ribosome entry sites mediate the translation of p53 isoforms.
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5 July 2018
Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish.
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5 July 2018
Characterisation of a novel p53 down-regulated promoter in intron 3 of the human MDM2 oncogene
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5 July 2018
p53 isoforms can regulate p53 transcriptional activity.
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5 July 2018
Regulation of human p53 activity and cell localization by alternative splicing
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5 July 2018
The common and distinct target genes of the p53 family transcription factors
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5 July 2018
Modulation of mammalian life span by the short isoform of p53.
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5 July 2018
Repression of transcription and interference with DNA binding of TATA-binding protein by C-terminal alternatively spliced p53.
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5 July 2018
p53 mutant mice that display early ageing-associated phenotypes
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5 July 2018
Negative regulation of bcl-2 expression by p53 in hematopoietic cells
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5 July 2018
p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours
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5 July 2018
p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53
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5 July 2018
p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor
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5 July 2018
p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
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PubMed Central
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5 July 2018
Identification of a novel p53 functional domain that is necessary for mediating apoptosis
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PubMed Central
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5 July 2018
Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
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PubMed Central
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5 July 2018
Activities and response to DNA damage of latent and active sequence-specific DNA binding forms of mouse p53.
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PubMed Central
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5 July 2018
DNA binding specificity of proteins derived from alternatively spliced mouse p53 mRNAs
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5 July 2018
The murine C'-terminally alternatively spliced form of p53 induces attenuated apoptosis in myeloid cells
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5 July 2018
The human tumour suppressor gene p53 is alternatively spliced in normal cells
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5 July 2018
p53 is required for radiation-induced apoptosis in mouse thymocytes
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135639
retrieved
5 July 2018
Genetic alterations in the p53 gene in the blast crisis of chronic myelogenous leukemia: analysis by polymerase chain reaction based techniques
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135639
retrieved
5 July 2018
Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135639
retrieved
5 July 2018
Alternative splicing of the p53 tumor suppressor gene in the Molt-4 T-lymphoblastic leukemia cell line
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135639
retrieved
5 July 2018
Endogenous p53 protein generated from wild-type alternatively spliced p53 RNA in mouse epidermal cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135639
retrieved
5 July 2018
p53 domains: structure, oligomerization, and transformation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135639
retrieved
5 July 2018
Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135639
retrieved
5 July 2018
Wild-type alternatively spliced p53: binding to DNA and interaction with the major p53 protein in vitro and in cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135639
retrieved
5 July 2018
Allosteric activation of latent p53 tetramers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135639
retrieved
5 July 2018
Augmented DNA-binding activity of p53 protein encoded by a carboxyl-terminal alternatively spliced mRNA is blocked by p53 protein encoded by the regularly spliced form
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135639
retrieved
5 July 2018
Species- and tissue-specific expression of the C-terminal alternatively spliced form of the tumor suppressor p53.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135639
retrieved
5 July 2018
Immunologically distinct p53 molecules generated by alternative splicing
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135639
retrieved
5 July 2018
Isolation of a full-length mouse cDNA clone coding for an immunologically distinct p53 molecule
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135639
retrieved
5 July 2018
Alternatively spliced p53 RNA in transformed and normal cells of different tissue types
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135639
retrieved
5 July 2018
Formation of stable p53 homotetramers and multiples of tetramers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135639
retrieved
5 July 2018
Regulation of the specific DNA binding function of p53
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135639
retrieved
5 July 2018
Definition of a consensus binding site for p53
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135639
retrieved
5 July 2018
TAp73 acts via the bHLH Hey2 to promote long-term maintenance of neural precursors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135639
retrieved
28 October 2018
Alternative splicing of p53 and p73: the novel p53 splice variant p53delta is an independent prognostic marker in ovarian cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135639
retrieved
28 October 2018
Expression of p53 isoforms in renal cell carcinoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135639
retrieved
28 October 2018
p63 consensus DNA-binding site: identification, analysis and application into a p63MH algorithm.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135639
retrieved
28 October 2018
p53 linear diffusion along DNA requires its C terminus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135639
retrieved
28 October 2018
DeltaN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135639
retrieved
28 October 2018
Dynamic interactions of p53 with DNA in solution by time-lapse atomic force microscopy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135639
retrieved
28 October 2018
The role of the C' terminus of murine p53 in the p53/mdm-2 regulatory loop.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135639
retrieved
28 October 2018
Small peptides activate the latent sequence-specific DNA binding function of p53.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3135639
retrieved
28 October 2018
p63 and p73 are required for p53-dependent apoptosis in response to DNA damage
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21779513
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21779513
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Further characterisation of the p53 responsive element--identification of new candidate genes for trans-activation by p53
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21779513
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
p53-dependent apoptosis is regulated by a C-terminally alternatively spliced form of murine p53
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21779513
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
p53 Stability and activity is regulated by Mdm2-mediated induction of alternative p53 translation products
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21779513
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A distinct p53 protein isoform signature reflects the onset of induction chemotherapy for acute myeloid leukemia
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21779513
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1177/1947601911408893
1 reference
stated in
Europe PubMed Central
PMCID
3135639
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21779513%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
PMCID
3135639
1 reference
stated in
Europe PubMed Central
PMCID
3135639
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21779513%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
PubMed ID
21779513
1 reference
stated in
Europe PubMed Central
PMCID
3135639
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21779513%20AND%20SRC:MED&resulttype=core&format=json
retrieved
8 February 2020
ResearchGate publication ID
51511943
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