(Q34205564)

31 July 2017

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title

Tie receptors: new modulators of angiogenic and lymphangiogenic responses (English)

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31 July 2017

Tie signaling pathway

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Gene Ontology release 2020-05-02

K Alitalo

4

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author name string

N Jones

series ordinal

1

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31 July 2017

K Iljin

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2

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31 July 2017

D J Dumont

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3

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31 July 2017

1 April 2001

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Nature Reviews Molecular Cell Biology

31 July 2017

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31 July 2017

2

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31 July 2017

4

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31 July 2017

257-267

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https://scigraph.springernature.com/pub.10.1038/35067005

31 July 2017

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cites work

Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor

1 reference

7 January 2021

Hyperplasia of lymphatic vessels in VEGF-C transgenic mice

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7 January 2021

Molecular regulation of lymphangiogenesis and targets for tissue oedema

1 reference

7 January 2021

Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis

1 reference

7 January 2021

VEGF-D promotes the metastatic spread of tumor cells via the lymphatics

1 reference

7 January 2021

Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis

1 reference

7 January 2021

Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema

1 reference

7 January 2021

Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3.

1 reference

7 January 2021

Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning

1 reference

7 January 2021

Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis

1 reference

7 January 2021

Angiopoietins 3 and 4: diverging gene counterparts in mice and humans

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7 January 2021

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1 reference

7 January 2021

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1 reference

7 January 2021

Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo

1 reference

7 January 2021

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

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7 January 2021

Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis

1 reference

7 January 2021

TIE1 and TIE2 receptor tyrosine kinases inversely regulate embryonic angiogenesis by the mechanism of intussusceptive microvascular growth

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7 January 2021

The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells.

1 reference

7 January 2021

Increased vascularization in mice overexpressing angiopoietin-1

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7 January 2021

Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1

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7 January 2021

Rescue of the early vascular defects in Tek/Tie2 null mice reveals an essential survival function

1 reference

7 January 2021

Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues.

1 reference

7 January 2021

Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity

1 reference

7 January 2021

Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF.

1 reference

7 January 2021

Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis

1 reference

7 January 2021

In situ expression of angiopoietins in astrocytomas identifies angiopoietin-2 as an early marker of tumor angiogenesis.

1 reference

7 January 2021

Expression of Tie1, Tie2, and angiopoietins 1, 2, and 4 in Kaposi's sarcoma and cutaneous angiosarcoma

1 reference

7 January 2021

Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization

1 reference

7 January 2021

Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2.

1 reference

7 January 2021

Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway

1 reference

7 January 2021

Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2

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7 January 2021

Allelic and locus heterogeneity in inherited venous malformations

1 reference

7 January 2021

Endothelial receptor tyrosine kinases activate the STAT signaling pathway: mutant Tie-2 causing venous malformations signals a distinct STAT activation response

1 reference

7 January 2021

Endothelial Tie growth factor receptor provides antigenic marker for assessment of breast cancer angiogenesis

1 reference

7 January 2021

Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis

1 reference

7 January 2021

Analysis of Tie receptor tyrosine kinase in haemopoietic progenitor and leukaemia cells

1 reference

7 January 2021

Hypoxia and vascular endothelial growth factor selectively up-regulate angiopoietin-2 in bovine microvascular endothelial cells

1 reference

7 January 2021

Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia.

1 reference

7 January 2021

The endothelial receptor tyrosine kinase tie-1 is upregulated by hypoxia and vascular endothelial growth factor.

1 reference

7 January 2021

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

1 reference

7 January 2021

Tie2 receptor expression is stimulated by hypoxia and proinflammatory cytokines in human endothelial cells

1 reference

7 January 2021

Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice

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7 January 2021

Role of ets factors in the activity and endothelial cell specificity of the mouse Tie gene promoter.

1 reference

7 January 2021

Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2

1 reference

7 January 2021

Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth

1 reference

7 January 2021

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

1 reference

7 January 2021

Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration

1 reference

7 January 2021

Angiopoietin-1 induces sprouting angiogenesis in vitro

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7 January 2021

Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2

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7 January 2021

Angiopoietin-1 is an apoptosis survival factor for endothelial cells

1 reference

7 January 2021

Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt

1 reference

7 January 2021

Role of PI 3-kinase in angiopoietin-1-mediated migration and attachment-dependent survival of endothelial cells

1 reference

7 January 2021

Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3'-Kinase/Akt signal transduction pathway

1 reference

7 January 2021

Angiopoietin-1 and its receptor Tie-2 participate in the regulation of capillary-like tubule formation and survival of endothelial cells

1 reference

7 January 2021

Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells

1 reference

7 January 2021

Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway

1 reference

7 January 2021

The survivin-like C. elegans BIR-1 protein acts with the Aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone

1 reference

7 January 2021

Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation

1 reference

7 January 2021

Angiopoietin-1 induces endothelial cell sprouting through the activation of focal adhesion kinase and plasmin secretion

1 reference

7 January 2021

The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R

1 reference

7 January 2021

HCPTPA, a protein tyrosine phosphatase that regulates vascular endothelial growth factor receptor-mediated signal transduction and biological activity.

1 reference

7 January 2021

Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2

1 reference

7 January 2021

Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail

1 reference

7 January 2021

Tie-1 receptor tyrosine kinase endodomain interaction with SHP2: potential signalling mechanisms and roles in angiogenesis

1 reference

7 January 2021

Evidence for heterotypic interaction between the receptor tyrosine kinases TIE-1 and TIE-2.

1 reference

7 January 2021

Angiopoietin-1 protects the adult vasculature against plasma leakage.

1 reference

7 January 2021

A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains

1 reference

7 January 2021

VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation

1 reference

7 January 2021

Vascular endothelial growth factor is essential for corpus luteum angiogenesis.

1 reference

7 January 2021

Upregulated expression of vascular endothelial growth factor in proliferative diabetic retinopathy

1 reference

7 January 2021

Molecular cloning and characterization of mouse TIE and TEK receptor tyrosine kinase genes and their expression in hematopoietic stem cells

1 reference

7 January 2021

Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis

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7 January 2021

A role for hematopoietic stem cells in promoting angiogenesis

1 reference

7 January 2021

Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis

1 reference

7 January 2021

Identification of a human VPF/VEGF 3' untranslated region mediating hypoxia-induced mRNA stability

1 reference

7 January 2021

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT.

1 reference

7 January 2021

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

1 reference

7 January 2021

The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling

1 reference

7 January 2021

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1 reference

7 January 2021

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

7 January 2021

The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity

1 reference

7 January 2021

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1 reference

7 January 2021

Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity

1 reference

7 January 2021

Characterization and expression of a novel alternatively spliced human angiopoietin-2

1 reference

7 January 2021

Characterization of a novel form of angiopoietin-2 (Ang-2B) and expression of VEGF and angiopoietin-2 during chicken testicular development and regression.

1 reference

7 January 2021

Recruitment of Dok-R to the EGF receptor through its PTB domain is required for attenuation of Erk MAP kinase activation

1 reference

7 January 2021

Identifiers

DOI

10.1038/35067005

1 reference

Dimensions Publication ID

31 July 2017

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