(Q34211132)

31 July 2017

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title

Overcoming antimicrobial resistance by targeting resistance mechanisms (English)

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31 July 2017

antimicrobial resistance

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Poole K

1

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31 July 2017

1 March 2001

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Journal of Pharmacy and Pharmacology

31 July 2017

1 reference

31 July 2017

53

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31 July 2017

283-294

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31 July 2017

3

1 reference

The effects of NorA inhibition on the activities of levofloxacin, ciprofloxacin and norfloxacin against two genetically related strains of Staphylococcus aureus in an in-vitro infection model.

31 July 2017

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives): a new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

7-Hydroxytropolone: an inhibitor of aminoglycoside-2"-O-adenylyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

A new chloramphenicol and florfenicol resistance gene flanked by two integron structures in Salmonella typhimurium DT104.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Effect of conalbumin on the activity of Syn 2190, a 1,5 dihydroxy-4-pyridon monobactam inhibitor of AmpC beta-lactamases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

In vitro activity of the new ketolide telithromycin compared with those of macrolides against Streptococcus pyogenes: influences of resistance mechanisms and methodological factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Factors influencing the accumulation of ciprofloxacin in Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Vancomycin-resistant enterococci

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Inhibitor-resistant TEM beta-lactamases: phenotypic, genetic and biochemical characteristics

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Activity of cefepime and other beta-lactam antibiotics against permeability mutants of Escherichia coli and Klebsiella pneumoniae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Recent progress in novel macrolides, quinolones, and 2-pyridones to overcome bacterial resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Molecular cloning and functional analysis of a novel macrolide-resistance determinant, mefA, from Streptococcus pyogenes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Bacterial resistance mechanisms as therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Inhibition of aminoglycoside antibiotic resistance enzymes by protein kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Antipneumococcal activity of ABT-773 compared to those of 10 other agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Synthesis and antibacterial activity of HMR 3647 a new ketolide highly potent against erythromycin-resistant and susceptible pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Unanticipated inhibition of the metallo-beta-lactamase from Bacteroides fragilis by 4-morpholineethanesulfonic acid (MES): a crystallographic study at 1.85-A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Combination studies between polycationic peptides and clinically used antibiotics against Gram-positive and Gram-negative bacteria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Modulation of erm methyltransferase activity by peptides derived from phage display

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Inhibition of transglycosylation involved in bacterial peptidoglycan synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Novel inhibitors of Erm methyltransferases from NMR and parallel synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

beta-lactam resistance in Streptococcus pneumoniae: penicillin-binding proteins and non-penicillin-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Alterations in outer membrane permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

The bacterial outer membrane as a drug barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Antibacterial peptides and the outer membranes of gram-negative bacilli

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Compounds which increase the permeability of the Pseudomonas aeruginosa outer membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Design and synthesis of mimics of S-adenosyl-L-homocysteine as potential inhibitors of erythromycin methyltransferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Structure-based design of beta-lactamase inhibitors. 1. Synthesis and evaluation of bridged monobactams.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Mechanisms of action and resistance of older and newer fluoroquinolones

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

The role of specific surface loop regions in determining the function of the imipenem-specific pore protein OprD of Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Design of potent beta-lactamase inhibitors by phage display of beta-lactamase inhibitory protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Mechanisms of quinolone resistance in clinical strains of Pseudomonas aeruginosa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Prevalence of gyrA, gyrB, parC, and parE mutations in clinical isolates of Streptococcus pneumoniae with decreased susceptibilities to different fluoroquinolones and originating from Worldwide Surveillance Studies during the 1997-1998 respiratory se

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Inducible NorA-mediated multidrug resistance in Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Aminoglycosides: perspectives on mechanisms of action and resistance and strategies to counter resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Bacterial resistance to macrolide, lincosamide, and streptogramin antibiotics by target modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Intrinsic and unusual resistance to macrolide, lincosamide, and streptogramin antibiotics in bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Beta-lactamase-mediated resistance and opportunities for its control.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Epidemiology of antibiotic resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Molecular cloning and characterization of acrA and acrE genes of Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Substituted salicylanilides as inhibitors of two-component regulatory systems in bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

A plasmid that encodes three genes for resistance to macrolide antibiotics in Staphylococcus aureus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Contributions of the AmpC beta-lactamase and the AcrAB multidrug efflux system in intrinsic resistance of Escherichia coli K-12 to beta-lactams

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Evidence for chloramphenicol/H+ antiport in Cmr (MdfA) system of Escherichia coli and properties of the antiporter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Inhibition of the broad spectrum nonmetallocarbapenamase of class A (NMC-A) beta-lactamase from Enterobacter cloacae by monocyclic beta-lactams.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Inhibition of the tetracycline efflux antiport protein by 13-thio-substituted 5-hydroxy-6-deoxytetracyclines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Molecular requirements for the inhibition of the tetracycline antiport protein and the effect of potent inhibitors on the growth of tetracycline-resistant bacteria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Structure-based design guides the improved efficacy of deacylation transition state analogue inhibitors of TEM-1 beta-Lactamase(,)

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Prevention of drug access to bacterial targets: permeability barriers and active efflux

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

The role of outer membrane and efflux pumps in the resistance of gram-negative bacteria. Can we improve drug access?

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Ineffectiveness of topoisomerase mutations in mediating clinically significant fluoroquinolone resistance in Escherichia coli in the absence of the AcrAB efflux pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Dual inhibitory activity of sitafloxacin (DU-6859a) against DNA gyrase and topoisomerase IV of Streptococcus pneumoniae

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

beta-Lactamase epidemiology and the utility of established and novel beta-lactamase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Intracellular targets of moxifloxacin: a comparison with other fluoroquinolones

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Improvement of outer membrane-permeabilizing and lipopolysaccharide-binding activities of an antimicrobial cationic peptide by C-terminal modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Efflux-mediated resistance to fluoroquinolones in gram-positive bacteria and the mycobacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Efflux-mediated resistance to fluoroquinolones in gram-negative bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

The complexed structure and antimicrobial activity of a non-β-lactam inhibitor of AmpC β-lactamase

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Inhibitors of efflux pumps in Pseudomonas aeruginosa potentiate the activity of the fluoroquinolone antibacterial levofloxacin

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Glycopeptide resistance mediated by enterococcal transposon Tn1546 requires production of VanX for hydrolysis of D-alanyl-D-alanine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Inducible erythromycin resistance in staphylococci is encoded by a member of the ATP-binding transport super-gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

The acrAB homolog of Haemophilus influenzae codes for a functional multidrug efflux pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

In vitro potency of moxifloxacin, clinafloxacin and sitafloxacin against 248 genetically defined clinical isolates of Staphylococcus aureus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Prevalence of macrolide-resistance genes in Staphylococcus aureus and Enterococcus faecium isolates from 24 European university hospitals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Prevalence of macrolide resistance mechanisms in Streptococcus pneumoniae isolates from a multicenter antibiotic resistance surveillance study conducted in the United States in 1994-1995.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

A novel glycylcycline, 9-(N,N-dimethylglycylamido)-6-demethyl-6-deoxytetracycline, is neither transported nor recognized by the transposon Tn10-encoded metal-tetracycline/H+ antiporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Contribution of the MexAB-OprM multidrug efflux system to the beta-lactam resistance of penicillin-binding protein and beta-lactamase-derepressed mutants of Pseudomonas aeruginosa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5'-methoxyhydnocarpin, a multidrug pump inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Salmonella typhimurium and Escherichia coli mutants with increased outer membrane permeability to hydrophobic compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Mechanisms of 4-quinolone resistance in quinolone-resistant and methicillin-resistant Staphylococcus aureus isolates from Japan and China.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Susceptibilities of Neisseria gonorrhoeae isolates containing amino acid substitutions in GyrA, with or without substitutions in ParC, to newer fluoroquinolones and other antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

In vitro and in vivo antibacterial activities of the glycylcyclines, a new class of semisynthetic tetracyclines

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Version 2000: the new beta-lactamases of Gram-negative bacteria at the dawn of the new millennium

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Antibiotic sensitization using biphenyl tetrazoles as potent inhibitors of Bacteroides fragilis metallo-beta-lactamase

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Antibiotic-supersusceptible mutants of Escherichia coli and Salmonella typhimurium

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Outer membrane permeability barrier to azithromycin, clarithromycin, and roxithromycin in gram-negative enteric bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

5-epi-Sisomicin and 5-epi-Gentamicin B: substrates for aminoglycoside-modifying enzymes that retain activity against aminoglycoside-resistant bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

The lipid A biosynthesis mutation lpxA2 of Escherichia coli results in drastic antibiotic supersusceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Erythromycin resistance by ribosome modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Structure-based enhancement of boronic acid-based inhibitors of AmpC beta-lactamase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Aminoglycoside-modifying enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Resisting resistance: new chemical strategies for battling superbugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Interaction of the cyclic antimicrobial cationic peptide bactenecin with the outer and cytoplasmic membrane.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Phosphinate analogs of D-, D-dipeptides: slow-binding inhibition and proteolysis protection of VanX, a D-, D-dipeptidase required for vancomycin resistance in Enterococcus faecium

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Overexpression, purification, and characterization of VanX, a D-, D-dipeptidase which is essential for vancomycin resistance in Enterococcus faecium BM4147.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Mechanisms of high-level resistance to quinolones in urinary tract isolates of Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Development of multiple-antibiotic-resistant (Mar) mutants of Pseudomonas aeruginosa after serial exposure to fluoroquinolones

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Interactions of bacterial cationic peptide antibiotics with outer and cytoplasmic membranes of Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Tetracycline resistance determinants: mechanisms of action, regulation of expression, genetic mobility, and distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Macrolide-ketolide inhibition of MLS-resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

The effect of reserpine, an inhibitor of multi-drug efflux pumps, on the in-vitro susceptibilities of fluoroquinolone-resistant strains of Streptococcus pneumoniae to norfloxacin

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

The synthesis and evaluation of 2-substituted-7-(alkylidene)cephalosporin sulfones as beta-lactamase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

The synthesis and evaluation of 3-substituted-7-(alkylidene)cephalosporin sulfones as beta-lactamase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Assays to detect and characterize synthetic agents that inhibit the ErmC methyltransferase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

The emergence of Streptococcus pneumoniae resistant to macrolide antimicrobial agents: a 6-year population-based assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

The synthesis and SAR of rhodanines as novel class C beta-lactamase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Clinical impact of antibiotic resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Interplay between the MexA-MexB-OprM multidrug efflux system and the outer membrane barrier in the multiple antibiotic resistance of Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Potentiation of beta-lactams against Pseudomonas aeruginosa strains by Ro 48-1256, a bridged monobactam inhibitor of AmpC beta-lactamases

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

An inhibitor of chloramphenicol acetyltransferase produced by Streptomyces

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Macrolide esterase-producing Escherichia coli clinically isolated in Japan

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

The interaction of a recombinant cecropin/melittin hybrid peptide with the outer membrane of Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Design, synthesis, and evaluation of 2 beta-alkenyl penam sulfone acids as inhibitors of beta-lactamases

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

The use of neamine as a molecular template: inactivation of bacterial antibiotic resistance enzyme aminoglycoside 3'-phosphotransferase type IIa

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Dipolar cycloaddition of novel 6-(nitrileoxidomethyl) penam sulfone: an efficient route to a new class of beta-lactamase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

The effect of reserpine, an inhibitor of multidrug efflux pumps, on the in-vitro activities of ciprofloxacin, sparfloxacin and moxifloxacin against clinical isolates of Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

Hydroxamate Inhibitors ofAeromonas hydrophilaAE036 Metallo-B-lactamase

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357011775514

21 January 2018

Identifiers

DOI

10.1211/0022357011775514

1 reference

31 July 2017

1 reference

PubMed ID

11291743