(Q34213934)

31 July 2017

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title

DNA damage from micronutrient deficiencies is likely to be a major cause of cancer (English)

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31 July 2017

0 references

1

Ames BN

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PubMed ID

11295149

31 July 2017

language of work or name

English

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publication date

1 April 2001

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31 July 2017

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31 July 2017

475

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31 July 2017

7-20

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31 July 2017

1-2

1 reference

Oxidants, antioxidants, and the degenerative diseases of aging

31 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Vegetables, fruit, and cancer prevention: a review

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Nutrition and cancer: a summary of the evidence

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Cancer incidence among California Seventh-Day Adventists, 1976-1982.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Fruit and vegetable intakes of children and adolescents in the United States.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

US adults' fruit and vegetable intakes, 1989 to 1991: a revised baseline for the Healthy People 2000 objective

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Environmental pollution, pesticides, and the prevention of cancer: misconceptions.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Psychosocial factors associated with fruit and vegetable consumption

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Correction and revision of conclusions--dietary trends in the United States

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Analysis of folate data from the second National Health and Nutrition Examination Survey (NHANES II).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Folate intake and food sources in the US population

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Folacin and iron status and hematological findings in predominately black elderly persons from urban low-income households

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Folacin and iron status and hematological findings in black and Spanish-American adolescents from urban low-income households

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Folate, vitamin B12, homocysteine status and chromosome damage rate in lymphocytes of older men

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Folate, Methionine, and Alcohol Intake and Risk of Colorectal Adenoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Multivitamin use, folate, and colon cancer in women in the Nurses' Health Study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Elevation of homocysteine and excitatory amino acid neurotransmitters in the CSF of children who receive methotrexate for the treatment of cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Homocysteine and cardiovascular disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Folate and Vitamin B 6 From Diet and Supplements in Relation to Risk of Coronary Heart Disease Among Women

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Folic acid fortification of the food supply. Potential benefits and risks for the elderly population

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Primary prevention of coronary heart disease in women through diet and lifestyle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Hyperhomocyst(e)inemia is a risk factor for arterial endothelial dysfunction in humans.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Is mutated MTHFR a risk factor for neural tube defects?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Cancer prevention and diet: help from single nucleotide polymorphisms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Low seminal plasma folate concentrations are associated with low sperm density and count in male smokers and nonsmokers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Role of cobalamin intake and atrophic gastritis in mild cobalamin deficiency in older Dutch subjects

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Micronucleus frequency in human lymphocytes is related to plasma vitamin B12 and homocysteine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Vitamin B-6 requirement and status assessment of young women fed a high-protein diet with various levels of vitamin B-6

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

A case-control study of diet and prostate cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease. European COMAC Group

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Steady-state turnover and body pool of ascorbic acid in man

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Ascorbic acid protects against endogenous oxidative DNA damage in human sperm

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Citrus fruit supplementation reduces lipoprotein oxidation in young men ingesting a diet high in saturated fat: presumptive evidence for an interaction between vitamins C and E in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Can antioxidant vitamins materially reduce oxidative damage in humans?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Nutrient intake and cataract extraction in women: a prospective study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Long-term vitamin C supplement use and prevalence of early age-related lens opacities

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

DNA oxidation matters: the HPLC-electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

A simpler, more robust method for the analysis of 8-oxoguanine in DNA

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

'Spontaneous' genetic damage in man: evaluation of interindividual variability, relationship among markers of damage, and influence of nutritional status

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Nutrition and renal cell cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Nutrition and pancreatic cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Nutrition and stomach cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

The role of ascorbic acid in oral cancer and carcinogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Antioxidant vitamin C improves endothelial dysfunction in chronic smokers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Vitamin C intake and mortality among a sample of the United States population.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Ascorbate is depleted by smoking and repleted by moderate supplementation: a study in male smokers and nonsmokers with matched dietary antioxidant intakes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Smoking and low antioxidant levels increase oxidative damage to sperm DNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

How much do we know about spontaneous human mutation rates?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Paternal Cigarette Smoking and the Risk of Childhood Cancer Among Offspring of Nonsmoking Mothers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Childhood cancer and parental use of alcohol and tobacco

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Childhood cancer and parental use of tobacco: deaths from 1953 to 1955.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Childhood cancer and parental use of tobacco: deaths from 1971 to 1976.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Antioxidant micronutrients and childhood malignancy during oncological treatment.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

The causes and prevention of cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

gamma-tocopherol traps mutagenic electrophiles such as NO(X) and complements alpha-tocopherol: physiological implications

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Products of gamma-tocopherol reaction with NO2 and their formation in rat insulinoma (RINm5F) cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Inflammation and NO(X)-induced nitration: assay for 3-nitrotyrosine by HPLC with electrochemical detection

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

gamma-tocopherol and its major metabolite, in contrast to alpha-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Effects of supplemental alpha-tocopherol and beta-carotene on colorectal cancer: results from a controlled trial (Finland)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Prostate Cancer and Supplementation With α-Tocopherol and β-Carotene: Incidence and Mortality in a Controlled Trial

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Antioxidants and dementia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Antioxidant vitamins and cardiovascular disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Dietary antioxidant vitamins and death from coronary heart disease in postmenopausal women

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Vitamin E and vitamin C supplement use and risk of all-cause and coronary heart disease mortality in older persons: the Established Populations for Epidemiologic Studies of the Elderly

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Vitamin E consumption and the risk of coronary heart disease in men.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Epidemiologic evidence for vitamin E in prevention of cardiovascular disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Antioxidants and atherosclerotic heart disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Will the 'good fairies' please prove to us that vitamin E lessens human degenerative disease?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Erythrocyte vitamin E and plasma ascorbate concentrations in relation to erythrocyte peroxidation in smokers and nonsmokers: dose response to vitamin E supplementation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Effects of selenium and vitamin E on the immune responses of domestic animals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Vitamin C supplementation of the maternal diet reduces the rate of malformation in the offspring of diabetic rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Deliberations and evaluations of the approaches, endpoints and paradigms for selenium and iodine dietary recommendations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Selenium and risk of prostate cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Study of prediagnostic selenium level in toenails and the risk of advanced prostate cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Prospective study of serum micronutrients and ovarian cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Thyroid hormones and selenium status in breast cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Inhibitory effect of selenomethionine on the growth of three selected human tumor cell lines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Plasma selenium levels and the risk of colorectal adenomas.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Correlation of cervical cancer mortality with reproductive and dietary factors, and serum markers in China

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Selenoprotein P in plasma in relation to cancer morbidity in middle-aged Swedish men.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Selenium: Biochemical Role as a Component of Glutathione Peroxidase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Liver necrosis and lipid peroxidation in the rat as the result of paraquat and diquat administration. Effect of selenium deficiency

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Dietary selenium intake controls rat plasma selenoprotein P concentration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

The diverse role of selenium within selenoproteins: a review

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

The metabolism of high intakes of tryptophan, nicotinamide and nicotinic acid in the rat.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Niacin deficiency and cancer in women

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Mapping the role of NAD metabolism in prevention and treatment of carcinogenesis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Dietary niacin deficiency lowers tissue poly(ADP-ribose) and NAD+ concentrations in Fischer-344 rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Male rats fed methyl- and folate-deficient diets with or without niacin develop hepatic carcinomas associated with decreased tissue NAD concentrations and altered poly(ADP-ribose) polymerase activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Both iron deficiency and daily iron supplements increase lipid peroxidation in rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Iron-induced carcinogenesis: the role of redox regulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Association between body iron stores and the risk of acute myocardial infarction in men.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

The iron hypothesis--does iron cause atherosclerosis?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Zinc: health effects and research priorities for the 1990s

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Maternal dietary zinc influences DNA strand break and 8-hydroxy-2'-deoxyguanosine levels in infant rhesus monkey liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Oxidant defense systems in testes from zinc-deficient rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Cell proliferation and esophageal carcinogenesis in the zinc-deficient rat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Induction of esophageal tumors in zinc-deficient rats by single low doses of N-nitrosomethylbenzylamine (NMBA): analysis of cell proliferation, and mutations in H-ras and p53 genes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Esophageal carcinogenesis in the rat: zinc deficiency, DNA methylation and alkyltransferase activity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Protective action of zinc against cobalt-induced testicular damage in the mouse

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Concentrations of cadmium, lead, selenium, and zinc in human blood and seminal plasma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

A 14-mo zinc-supplementation trial in apparently healthy Chilean preschool children.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Mild human zinc deficiency produces an imbalance between cell-mediated and humoral immunity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Micronutrient supplementation and infection in institutionalized elders

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Eat right and take a multivitamin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Micronutrients prevent cancer and delay aging

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

Micronutrient deficiencies. A major cause of DNA damage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0027-5107%2801%2900070-7

10.1016/S0027-5107(01)00070-7

7 January 2021

Identifiers

DOI

1 reference

31 July 2017

1 reference

PubMed ID

11295149