(Q34229190)

31 July 2017

title

Abnormal microRNA expression in Ts65Dn hippocampus and whole blood: contributions to Down syndrome phenotypes (English)

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31 July 2017

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Jennifer Keck-Wherley

1

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31 July 2017

Deepak Grover

2

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31 July 2017

Sharmistha Bhattacharyya

3

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31 July 2017

Xiufen Xu

4

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31 July 2017

Derek Holman

5

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31 July 2017

Eric D Lombardini

6

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31 July 2017

Ranjana Verma

7

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31 July 2017

Roopa Biswas

8

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31 July 2017

Zygmunt Galdzicki

9

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31 July 2017

publication date

27 October 2011

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Developmental Neuroscience

31 July 2017

published in

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31 July 2017

volume

33

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31 July 2017

issue

5

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31 July 2017

page(s)

451-467

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describes a project that uses

31 July 2017

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/3254042

inferred from PubMed Central ID database lookup

cites work

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28 July 2018

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28 July 2018

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Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human Down syndrome brains

28 July 2018

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28 July 2018

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28 July 2018

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MicroRNA expression profiling of megakaryocytes in primary myelofibrosis and essential thrombocythemia

28 July 2018

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A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures.

28 July 2018

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miR-200 expression regulates epithelial-to-mesenchymal transition in bladder cancer cells and reverses resistance to epidermal growth factor receptor therapy

28 July 2018

1 reference

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The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies

28 July 2018

1 reference

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Src homology 2 domain-containing inositol-5-phosphatase and CCAAT enhancer-binding protein beta are targeted by miR-155 in B cells of Emicro-MiR-155 transgenic mice

28 July 2018

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A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis

28 July 2018

1 reference

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A microRNA imparts robustness against environmental fluctuation during development

28 July 2018

1 reference

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Inositol phosphatase SHIP1 is a primary target of miR-155

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Transcriptional inhibiton of Hoxd4 expression by miRNA-10a in human breast cancer cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

MicroRNAs: target recognition and regulatory functions

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Regulation of postsynaptic AMPA responses by synaptojanin 1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Most mammalian mRNAs are conserved targets of microRNAs

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

c-Rel, an NF-kappaB family transcription factor, is required for hippocampal long-term synaptic plasticity and memory formation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

miRNA analysis in B-cell chronic lymphocytic leukaemia: proliferation centres characterized by low miR-150 and high BIC/miR-155 expression

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Tyrosine phosphorylation of netrin receptors in netrin-1 signaling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Computational methods for analysis of cellular functions and pathways collectively targeted by differentially expressed microRNA.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Switching from repression to activation: microRNAs can up-regulate translation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Increased incidence of idiopathic persistent pulmonary hypertension in Down syndrome neonates

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Stress-induced reversal of microRNA repression and mRNA P-body localization in human cells.

28 July 2018

1 reference

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The evolution of gene regulation by transcription factors and microRNAs

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Zebrafish miR-214 modulates Hedgehog signaling to specify muscle cell fate

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

miR-7b, a microRNA up-regulated in the hypothalamus after chronic hyperosmolar stimulation, inhibits Fos translation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Comparative sequence analysis reveals an intricate network among REST, CREB and miRNA in mediating neuronal gene expression

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Understanding the basis for Down syndrome phenotypes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Chromosome 21 and down syndrome: from genomics to pathophysiology

28 July 2018

1 reference

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Gene-dosage effects in Down syndrome and trisomic mouse models

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Gene expression from the aneuploid chromosome in a trisomy mouse model of down syndrome

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Role of reactive oxygen species in vascular remodeling associated with pulmonary hypertension

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Down's syndrome: a genetic disorder in biobehavioral perspective

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

The neuropsychology of Down syndrome: evidence for hippocampal dysfunction

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Incidence of alveolar capillary dysplasia in severe idiopathic persistent pulmonary hypertension of the newborn

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Too much of a good thing: mechanisms of gene action in Down syndrome.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

The mouse brain transcriptome by SAGE: differences in gene expression between P30 brains of the partial trisomy 16 mouse model of Down syndrome (Ts65Dn) and normals

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

The management of neoplastic disorders of haematopoiesis in children with Down's syndrome

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Role of founder cell deficit and delayed neuronogenesis in microencephaly of the trisomy 16 mouse.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Risks of leukaemia and solid tumours in individuals with Down's syndrome.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Oxidative stress and neural dysfunction in Down syndrome.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Altered long-term potentiation in the young and old Ts65Dn mouse, a model for Down Syndrome.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

A mouse model for Down syndrome exhibits learning and behaviour deficits.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Developmental consequences of autosomal aneuploidy in mammals

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Molecular definition of a region of chromosome 21 that causes features of the Down syndrome phenotype

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Protocols to establish genotype-phenotype correlations in Down syndrome

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Calcium-dependent component of massive increase in extracellular potassium during cerebral ischemia as demonstrated by microdialysis in vivo

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Dosage-dependent over-expression of genes in the trisomic region of Ts1Cje mouse model for Down syndrome.

28 July 2018

1 reference

Down syndrome: the crucible for treating genomic imbalance.

21 January 2018

1 reference

A chromosome 21 critical region does not cause specific Down syndrome phenotypes.

21 January 2018

1 reference

Epigenetics, copy number variation, and other molecular mechanisms underlying neurodevelopmental disabilities: new insights and diagnostic approaches

21 January 2018

1 reference

Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3' untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes

21 January 2018

1 reference

Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts

21 January 2018

1 reference

MeCP2-dependent repression of an imprinted miR-184 released by depolarization

21 January 2018

1 reference

A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis

21 January 2018

1 reference

Dicer and eIF2c are enriched at postsynaptic densities in adult mouse brain and are modified by neuronal activity in a calpain-dependent manner

21 January 2018

1 reference

microRNA regulation of synaptic plasticity

21 January 2018

1 reference

MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function

21 January 2018

1 reference

Inducible repression of CREB function disrupts amygdala-dependent memory

21 January 2018

1 reference

Synaptojanin-1 plays a key role in astrogliogenesis: possible relevance for Down's syndrome

21 January 2018

1 reference

Mouse models of Down syndrome: how useful can they be? Comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions

21 January 2018

1 reference

Ts65Dn -- localization of the translocation breakpoint and trisomic gene content in a mouse model for Down syndrome

21 January 2018

1 reference

Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome.

21 January 2018

1 reference

A behavioral assessment of Ts65Dn mice: a putative Down syndrome model.

21 January 2018

1 reference

Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome.

21 January 2018

1 reference

A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.

21 January 2018

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miRDB: a microRNA target prediction and functional annotation database with a wiki interface

21 January 2018

1 reference

Altered signaling pathways underlying abnormal hippocampal synaptic plasticity in the Ts65Dn mouse model of Down syndrome.

21 January 2018

1 reference

Mitochondrial dysfunction and tau hyperphosphorylation in Ts1Cje, a mouse model for Down syndrome.

21 January 2018

1 reference

Molecular genetic analysis of Down syndrome

21 January 2018

1 reference

Understanding mental retardation in Down's syndrome using trisomy 16 mouse models

21 January 2018

1 reference

Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1

21 January 2018

1 reference

Somatodendritic microRNAs identified by laser capture and multiplex RT-PCR.

21 January 2018

1 reference

From synapse to nucleus: calcium-dependent gene transcription in the control of synapse development and function

21 January 2018

1 reference

Regulation of pri-microRNA BIC transcription and processing in Burkitt lymphoma.

21 January 2018

1 reference

Cross talk between microRNA and epigenetic regulation in adult neurogenesis

21 January 2018

1 reference

Fluoxetine rescues deficient neurogenesis in hippocampus of the Ts65Dn mouse model for Down syndrome.

21 January 2018

1 reference

Lithium restores neurogenesis in the subventricular zone of the Ts65Dn mouse, a model for Down syndrome

21 January 2018

1 reference

Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse.

21 January 2018

1 reference

Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for Down syndrome

21 January 2018

1 reference

Modulation of adult hippocampal neurogenesis during myelin-directed autoimmune neuroinflammation.

21 January 2018

1 reference

Traumatic brain injury alters expression of hippocampal microRNAs: potential regulators of multiple pathophysiological processes.

21 January 2018

1 reference

Cyclosporin ameliorates traumatic brain-injury-induced alterations of hippocampal synaptic plasticity.

21 January 2018

1 reference

miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia

21 January 2018

1 reference

Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study

21 January 2018

1 reference

Global disruption of the cerebellar transcriptome in a Down syndrome mouse model.

21 January 2018

1 reference

The cerebellar transcriptome during postnatal development of the Ts1Cje mouse, a segmental trisomy model for Down syndrome.

21 January 2018

1 reference

Oxidative stress and cognitive ability in adults with Down syndrome.

21 January 2018

1 reference

Widespread proliferation impairment and hypocellularity in the cerebellum of fetuses with down syndrome.

21 January 2018

1 reference

Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes.

21 January 2018

1 reference

Differential expression of specific microRNA and their targets in acute myeloid leukemia.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

c-fos expression in brains of patients with Down syndrome

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254042

Hematologic abnormalities in children with Down syndrome

28 October 2018

1 reference

12 December 2020

Non-disjunction of chromosome 21 in maternal meiosis I: evidence for a maternal age-dependent mechanism involving reduced recombination

1 reference

12 December 2020

Reactive oxygen intermediates during programmed cell death induced in the thymus of the Ts(1716)65Dn mouse, a murine model for human Down's syndrome

1 reference

12 December 2020

Characterization of the cardiac phenotype in neonatal Ts65Dn mice

1 reference

12 December 2020

Peripheral blood cell counts in infants with Down's syndrome

1 reference

12 December 2020

Hypomethylated DSCR4 is a placenta-derived epigenetic marker for trisomy 21

1 reference

12 December 2020

MicroRNA-223 expression in neutrophils in the early phase of secondary damage after spinal cord injury

1 reference

12 December 2020

Effect of Coenzyme Q10 in mitigating oxidative DNA damage in Down syndrome patients, a double blind randomized controlled trial

1 reference

12 December 2020

How valid are the rates of Down syndrome internationally? Findings from the International Clearinghouse for Birth Defects Surveillance and Research

1 reference

12 December 2020

Identifiers

DOI

10.1159/000330884

1 reference

31 July 2017

1 reference

31 July 2017

1 reference