(Q34235658)

31 July 2017

title

The role of the mitochondrial glycine cleavage complex in the metabolism and virulence of the protozoan parasite Leishmania major (English)

1 reference

pyridoxal phosphate containing glycine decarboxylase, putative

31 July 2017

main subject

1 reference

GeneDB

pyridoxal phosphate containing glycine decarboxylase, putative

5 February 2019

1 reference

GeneDB

pyridoxal phosphate containing glycine decarboxylase, putative

6 February 2019

0 references

1 reference

4

1 reference

31 July 2017

3

Tim J Vickers

1 reference

31 July 2017

David A Scott

1

1 reference

31 July 2017

Suzanne M Hickerson

series ordinal

2

1 reference

31 July 2017

language of work or name

English

0 references

publication date

2 November 2007

1 reference

Journal of Biological Chemistry

31 July 2017

published in

1 reference

31 July 2017

volume

283

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31 July 2017

issue

1

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31 July 2017

page(s)

155-165

1 reference

Comparisons of mutants lacking the Golgi UDP-galactose or GDP-mannose transporters establish that phosphoglycans are important for promastigote but not amastigote virulence in Leishmania major

31 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

Living in a phagolysosome; metabolism of Leishmania amastigotes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

Comparative genomic analysis of three Leishmania species that cause diverse human disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

In vivo negative selection screen identifies genes required for Francisella virulence

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

Metabolism of Leishmania: proven and predicted

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

Mitochondrial deoxynucleotide pool sizes in mouse liver and evidence for a transport mechanism for thymidine monophosphate

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

Miltefosine: issues to be addressed in the future.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

Retention and loss of amino acid biosynthetic pathways based on analysis of whole-genome sequences

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

The genome of the kinetoplastid parasite, Leishmania major

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

The Genome of the African Trypanosome Trypanosoma brucei

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

Leishmania salvage and remodelling of host sphingolipids in amastigote survival and acidocalcisome biogenesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

Genetic requirements for mycobacterial survival during infection

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

Thymidylate synthase inhibitors as anticancer agents: from bench to bedside

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

Improvements in transfection efficiency and tests of RNA interference (RNAi) approaches in the protozoan parasite Leishmania

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

Genetic manipulation of glycine decarboxylation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

L-serine in disease and development

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

Rooting the eukaryote tree by using a derived gene fusion

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

Life without transcriptional control? From fly to man and back again

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

The glycine decarboxylase system: a fascinating complex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

Regulation of the balance of one-carbon metabolism in Saccharomyces cerevisiae

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

Fibroblasts as host cells in latent leishmaniosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

Identification of genes required for chronic persistence of Brucella abortus in mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

Role of mitochondrial and cytoplasmic serine hydroxymethyltransferase isozymes in de novo purine synthesis in Saccharomyces cerevisiae

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

Molecular characterization of GCV3, the Saccharomyces cerevisiae gene coding for the glycine cleavage system hydrogen carrier protein

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

In vivo analysis of folate coenzymes and their compartmentation in Saccharomyces cerevisiae

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

Mitochondria are a major site for folate and thymidylate synthesis in plants.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

Identification of an infective stage of Leishmania promastigotes.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

Purine and pyrimidine metabolism in the Trypanosomatidae

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

A limiting dilution assay for quantifying Leishmania major in tissues of infected mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

Effect of nitrous oxide inactivation of vitamin B12-dependent methionine synthetase on the subcellular distribution of folate coenzymes in rat liver

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

Stable transfection of the human parasite Leishmania major delineates a 30-kilobase region sufficient for extrachromosomal replication and expression

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

5-Formyltetrahydrofolate polyglutamates are slow tight binding inhibitors of serine hydroxymethyltransferase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

Double targeted gene replacement for creating null mutants

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

28 July 2018

2 references

https://api.crossref.org/works/10.1074%2FJBC.M708014200

21 January 2018

12 December 2020

Evidence that the High Incidence of Treatment Failures in Indian Kala‐Azar Is Due to the Emergence of Antimony‐Resistant Strains ofLeishmania donovani

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708014200

Plasma 25-hydroxyvitamin D does not vary over the course of a malarial infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708014200

Multiple transcription start sites of the carrot dihydrofolate reductase-thymidylate synthase gene, and sub-cellular localization of the bifunctional protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708014200

Stage specific gene expression and cellular localization of two isoforms of the serine hydroxymethyltransferase in the protozoan parasite Leishmania.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708014200

Structure of and kinetic channelling in bifunctional dihydrofolate reductase-thymidylate synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708014200

Ether phospholipids and glycosylinositolphospholipids are not required for amastigote virulence or for inhibition of macrophage activation by Leishmania major.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708014200

Rapid isolation of DNA from trypanosomatid protozoa using a simple 'mini-prep' procedure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708014200

Structure of P-protein of the glycine cleavage system: implications for nonketotic hyperglycinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708014200

Predicting subcellular localization of proteins based on their N-terminal amino acid sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708014200

Mitochondrial one-carbon metabolism is adapted to the specific needs of yeast, plants and mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708014200

Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708014200

The pathogen-inducible nitric oxide synthase (iNOS) in plants is a variant of the P protein of the glycine decarboxylase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708014200

Protozoan genomics for drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708014200

A natural model of Leishmania major infection reveals a prolonged "silent" phase of parasite amplification in the skin before the onset of lesion formation and immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708014200

Chronic lung inflammation affects plasma amino acid concentrations in pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708014200

Glycine decarboxylase multienzyme complex. Purification and partial characterization from pea leaf mitochondria

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963101

A lipophosphoglycan-independent method for isolation of infective Leishmania metacyclic promastigotes by density gradient centrifugation

28 October 2018

1 reference

12 December 2020

A bifunctional thymidylate synthetase-dihydrofolate reductase in protozoa

1 reference

12 December 2020

Uptake of 5-formyltetrahydrofolate in isolated rat liver mitochondria is carrier-mediated

1 reference

12 December 2020

Use of the green fluorescent protein as a marker in transfected Leishmania

1 reference

12 December 2020

Biochemical and genetic tests for inhibitors of Leishmania pteridine pathways

1 reference

12 December 2020

Pathophysiology of sepsis

1 reference

12 December 2020

Deletion of glycine decarboxylase in Arabidopsis is lethal under nonphotorespiratory conditions

1 reference

12 December 2020

Three dimensional structure of the Leishmania amastigote as revealed by computer-aided reconstruction from serial sections

1 reference

12 December 2020

The pathogen-inducible nitric oxide synthase (iNOS) in plants is a variant of the P protein of the glycine decarboxylase complex

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M708014200

1 reference

31 July 2017

1 reference

31 July 2017

1 reference