(Q34279769)

1 August 2017

title

Design, synthesis, and evaluation of duocarmycin O-amino phenol prodrugs subject to tunable reductive activation (English)

1 reference

1 August 2017

James P Lajiness

1

1 reference

1 August 2017

William M Robertson

2

1 reference

1 August 2017

Irene Dunwiddie

3

1 reference

1 August 2017

Melinda A Broward

4

1 reference

1 August 2017

George A Vielhauer

5

1 reference

1 August 2017

Scott J Weir

6

1 reference

1 August 2017

Dale L Boger

7

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1 August 2017

language of work or name

English

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publication date

1 November 2010

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Journal of Medicinal Chemistry

1 August 2017

published in

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1 August 2017

volume

53

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1 August 2017

issue

21

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1 August 2017

page(s)

7731-7738

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Studies toward the duocarmycin prodrugs for the antibody prodrug therapy approach

1 August 2017

cites work

1 reference

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6 July 2018

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Duocarmycin-based prodrugs for cancer prodrug monotherapy

6 July 2018

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A unique class of duocarmycin and CC-1065 analogues subject to reductive activation

6 July 2018

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Targeted cancer therapy: conferring specificity to cytotoxic drugs

6 July 2018

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Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity

6 July 2018

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Asymmetric total synthesis of (+)- and ent-(-)-yatakemycin and duocarmycin SA: evaluation of yatakemycin key partial structures and its unnatural enantiomer

6 July 2018

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Antitumor agents: development of highly potent glycosidic duocarmycin analogues for selective cancer therapy

6 July 2018

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Novel antitumor prodrugs designed for activation by matrix metalloproteinases-2 and -9.

6 July 2018

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Sequence-selective DNA recognition: natural products and nature's lessons

6 July 2018

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A human single-chain antibody specific for integrin alpha3beta1 capable of cell internalization and delivery of antitumor agents.

6 July 2018

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Synthesis and evaluation of nitroheterocyclic carbamate prodrugs for use with nitroreductase-mediated gene-directed enzyme prodrug therapy

6 July 2018

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Mechanisms of in situ activation for DNA-targeting antitumor agents

6 July 2018

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Duocarmycins--natures prodrugs?

6 July 2018

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A 2-nitroimidazole carbamate prodrug of 5-amimo-1-(chloromethyl)-3-[(5,6,7-trimethoxyindol-2-yl)carbony l]-1,2-dihydro-3H--benz[E]indole (amino-seco-CBI-TMI) for use with ADEPT and GDEPT.

6 July 2018

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CC-1065 and the duocarmycins: unraveling the keys to a new class of naturally derived DNA alkylating agents

6 July 2018

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6 July 2018

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Duocarmycin A, a new antitumor antibiotic from Streptomyces

6 July 2018

1 reference

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Glutathione deficiency produced by inhibition of its synthesis, and its reversal; Applications in research and therapy

6 July 2018

1 reference

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Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974002

Total synthesis, structure revision, and absolute configuration of (+)-yatakemycin

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974002

Effective asymmetric synthesis of 1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI).

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974002

DNA alkylation properties of yatakemycin

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974002

Yatakemycin, a novel antifungal antibiotic produced by Streptomyces sp. TP-A0356.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974002

Synthesis and preliminary cytotoxicity study of glucuronide derivatives of CC-1065 analogues

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974002

A Novel Class of CC-1065 and Duocarmycin Analogues Subject to Mitomycin-Related Reductive Activation

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974002

Glutathione levels and variability in breast tumors and normal tissue

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974002

Parallel assessment of glutathione-based detoxifying enzymes, O6-alkylguanine-DNA alkyltransferase and P-glycoprotein as indicators of drug resistance in tumor and normal lung of patients with lung cancer.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974002

Molecular basis for sequence selective DNA alkylation by (+)- and ent-(-)-CC-1065 and related agents: alkylation site models that accommodate the offset AT-rich adenine N3 alkylation selectivity

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974002

Enhancement of the selectivity and antitumor efficacy of a CC-1065 analogue through immunoconjugate formation.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974002

Characteristics of antitumor activity of KW-2189, a novel water-soluble derivative of duocarmycin, against murine and human tumors

28 October 2018

1 reference

12 December 2020

Duocarmycin SA, a new antitumor antibiotic from Streptomyces sp

1 reference

12 December 2020

CC-1065 and the Duocarmycins: Synthetic Studies

1 reference

12 December 2020

Molecular basis for sequence-specific DNA alkylation by CC-1065

1 reference

12 December 2020

CC-1065 (NSC 298223), a potent new antitumor agent improved production and isolation, characterization and antitumor activity

1 reference

12 December 2020

Catalysis of the CC-1065 and duocarmycin DNA alkylation reaction: DNA binding induced conformational change in the agent results in activation

1 reference

12 December 2020

CBI-CDPBO1 and CBI-CDPBI1: CC-1065 analogs containing deep-seated modifications in the DNA binding subunit

1 reference

12 December 2020

1,2,9,9a-Tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) analogs of CC-1065 and the duocarmycins: synthesis and evaluation

1 reference

12 December 2020

Yatakemycin: total synthesis, DNA alkylation, and biological properties

1 reference

12 December 2020

FR900482, a close cousin of mitomycin C that exploits mitosene-based DNA cross-linking

1 reference

12 December 2020

Cellular glutathione and thiol measurements from surgically resected human lung tumor and normal lung tissue

1 reference

12 December 2020

Yatakemycin, a Novel Antifungal Antibiotic Produced by Streptomyces sp. TP-A0356.

1 reference

COCI

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.56.107

Duocarmycin A, a new antitumor antibiotic from Streptomyces.

12 April 2024

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.41.1915

Identifiers

DOI

10.1021/JM1010397

1 reference

1 August 2017

1 reference

1 August 2017

1 reference