(Q34286305)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22646770%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

title

Differences in molecular genetics between pediatric and adult malignant astrocytomas: age matters (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22646770%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

1 reference

2

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2 February 2020

author name string

Stephen W Gilheeney

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22646770%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

language of work or name

English

0 references

publication date

1 May 2012

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22646770%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22646770%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

volume

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22646770%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22646770%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

page(s)

549-558

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Diagnosis of the small round blue cell tumors using multiplex polymerase chain reaction

2 February 2020

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Genetic aberrations leading to MAPK pathway activation mediate oncogene-induced senescence in sporadic pilocytic astrocytomas

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Clinical and molecular characteristics of malignant transformation of low-grade glioma in children

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Brain tumors: from childhood through adolescence into adulthood

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Identification of extensive genomic loss and gain by comparative genomic hybridisation in malignant astrocytoma in children and young adults.

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Pediatric high-grade astrocytomas show chromosomal imbalances distinct from adult cases

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Genome-wide allelic imbalance analysis of pediatric gliomas by single nucleotide polymorphic allele array.

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Genome-wide profiling using single-nucleotide polymorphism arrays identifies novel chromosomal imbalances in pediatric glioblastomas

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Cytogenetic analysis of paediatric astrocytoma using comparative genomic hybridisation and fluorescence in-situ hybridisation.

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Prognostic significance of histological grading, p53 status, YKL-40 expression, and IDH1 mutations in pediatric high-grade gliomas

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Lack of efficacy of bevacizumab plus irinotecan in children with recurrent malignant glioma and diffuse brainstem glioma: a Pediatric Brain Tumor Consortium study

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Genetic alterations in pediatric high-grade astrocytomas.

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Molecular analysis of astrocytomas presenting after age 10 in individuals with NF1.

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Neurofibromatosis type 1 and high-grade tumors of the central nervous system

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Gliomas presenting after age 10 in individuals with neurofibromatosis type 1 (NF1).

21 January 2018

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Frequent gains at chromosome 7q34 involving BRAF in pilocytic astrocytoma

21 January 2018

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BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas

21 January 2018

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Duplication of 7q34 is specific to juvenile pilocytic astrocytomas and a hallmark of cerebellar and optic pathway tumours

21 January 2018

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Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas.

21 January 2018

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Duplication of 7q34 in pediatric low-grade astrocytomas detected by high-density single-nucleotide polymorphism-based genotype arrays results in a novel BRAF fusion gene

21 January 2018

1 reference

Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma

21 January 2018

1 reference

BRAF-KIAA1549 fusion predicts better clinical outcome in pediatric low-grade astrocytoma.

21 January 2018

1 reference

Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma.

21 January 2018

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Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas.

21 January 2018

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Association of molecular alterations, including BRAF, with biology and outcome in pilocytic astrocytomas

21 January 2018

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Profiling critical cancer gene mutations in clinical tumor samples

21 January 2018

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BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications

21 January 2018

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Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma

21 January 2018

1 reference

Detection of KIAA1549-BRAF fusion transcripts in formalin-fixed paraffin-embedded pediatric low-grade gliomas.

21 January 2018

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Activation and activities of the p53 tumour suppressor protein

21 January 2018

1 reference

Preferential inactivation of the p53 tumor suppressor pathway and lack of EGFR amplification distinguish de novo high grade pediatric astrocytomas from de novo adult astrocytomas

21 January 2018

1 reference

Tyrosine kinase expression in pediatric high grade astrocytoma

21 January 2018

1 reference

Possible association of p53 codon 72 polymorphism with susceptibility to adult and pediatric high-grade astrocytomas.

21 January 2018

1 reference

Expression of p53 and prognosis in children with malignant gliomas.

21 January 2018

1 reference

Impact of morphology, MIB-1, p53 and MGMT on outcome in pilocytic astrocytomas

21 January 2018

1 reference

High frequency of TP53 mutations in juvenile pilocytic astrocytomas indicates role of TP53 in the development of these tumors

21 January 2018

1 reference

Absence of p53 gene mutations in a tumor panel representative of pilocytic astrocytoma diversity using a p53 functional assay

21 January 2018

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EGFR signaling and drug discovery.

21 January 2018

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PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme.

21 January 2018

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Prognostic effect of epidermal growth factor receptor and EGFRvIII in glioblastoma multiforme patients.

21 January 2018

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Clinical significance of EGFR amplification and the aberrant EGFRvIII transcript in conventionally treated astrocytic gliomas.

21 January 2018

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EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes

21 January 2018

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Expression of EGFR variant vIII promotes both radiation resistance and hypoxia tolerance

21 January 2018

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EGFRvIII and DNA double-strand break repair: a molecular mechanism for radioresistance in glioblastoma

21 January 2018

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EGFRvIII deletion mutations in pediatric high-grade glioma and response to targeted therapy in pediatric glioma cell lines

21 January 2018

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Nimotuzumab in pediatric glioma

21 January 2018

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Pediatric phase I and pharmacokinetic study of erlotinib followed by the combination of erlotinib and temozolomide: a Children's Oncology Group Phase I Consortium Study

21 January 2018

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Phase I and pharmacokinetic studies of erlotinib administered concurrently with radiotherapy for children, adolescents, and young adults with high-grade glioma.

21 January 2018

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Innovative Therapies for Children with Cancer pediatric phase I study of erlotinib in brainstem glioma and relapsing/refractory brain tumors

21 January 2018

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A phase I and biology study of gefitinib and radiation in children with newly diagnosed brain stem gliomas or supratentorial malignant gliomas

21 January 2018

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Nimotuzumab for pediatric diffuse intrinsic pontine gliomas

21 January 2018

1 reference

Homozygous loss of ADAM3A revealed by genome-wide analysis of pediatric high-grade glioma and diffuse intrinsic pontine gliomas

21 January 2018

1 reference

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

21 January 2018

1 reference

Protein expression of platelet-derived growth factor receptor correlates with malignant histology and PTEN with survival in childhood gliomas

21 January 2018

1 reference

Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor alpha and poly (ADP-ribose) polymerase as potential therapeutic targets

21 January 2018

1 reference

Marked regression of metastatic pilocytic astrocytoma during treatment with imatinib mesylate (STI-571, Gleevec): a case report and laboratory investigation

21 January 2018

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The Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validation: a 2009 update

21 January 2018

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The genetic basis of Cowden's syndrome: three novel mutations in PTEN/MMAC1/TEP1.

21 January 2018

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Pilocytic astrocytomas do not show most of the genetic changes commonly seen in diffuse astrocytomas

21 January 2018

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Preliminary observations on genetic alterations in pilocytic astrocytomas associated with neurofibromatosis 1

21 January 2018

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PTEN-mediated resistance to epidermal growth factor receptor kinase inhibitors

21 January 2018

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PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation

21 January 2018

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Clinical utility of fluorescence in situ hybridization (FISH) in nonbrainstem glioblastomas of childhood.

21 January 2018

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Molecular pathogenesis of pediatric astrocytic tumors

21 January 2018

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Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft

21 January 2018

1 reference

MGMT gene silencing and benefit from temozolomide in glioblastoma

21 January 2018

1 reference

O6-methylguanine-DNA methyltransferase expression strongly correlates with outcome in childhood malignant gliomas: results from the CCG-945 Cohort

21 January 2018

1 reference

Pharmacokinetics of O(6)-benzylguanine in pediatric patients with central nervous system tumors: a pediatric oncology group study

21 January 2018

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Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma

21 January 2018

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Phase I study of O6-benzylguanine and temozolomide administered daily for 5 days to pediatric patients with solid tumors.

21 January 2018

1 reference

MGMT promoter methylation correlates with survival benefit and sensitivity to temozolomide in pediatric glioblastoma

21 January 2018

1 reference

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

21 January 2018

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Temozolomide in the treatment of high-grade gliomas in children: a report from the Children's Oncology Group

21 January 2018

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Temozolomide in the treatment of children with newly diagnosed diffuse intrinsic pontine gliomas: a report from the Children's Oncology Group

21 January 2018

1 reference

Analysis of the IDH1 codon 132 mutation in brain tumors

21 January 2018

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IDH1 and IDH2 mutations in gliomas

21 January 2018

1 reference

Segregation of non-p.R132H mutations in IDH1 in distinct molecular subtypes of glioma

21 January 2018

1 reference

IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas

21 January 2018

1 reference

IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the Children's Oncology Group

21 January 2018

1 reference

Low level of microsatellite instability in paediatric malignant astrocytomas.

21 January 2018

1 reference

Incidence of p14ARF gene deletion in high-grade adult and pediatric astrocytomas.

21 January 2018

1 reference

Expression of p53, EGFR, pRb and bcl-2 proteins in pediatric glioblastoma multiforme: a study of 54 patients

21 January 2018

1 reference

Critical oncogenic mutations in newly diagnosed pediatric diffuse intrinsic pontine glioma

21 January 2018

1 reference

PIK3CA gene mutations in pediatric and adult glioblastoma multiforme.

21 January 2018

1 reference

MYB upregulation and genetic aberrations in a subset of pediatric low-grade gliomas

21 January 2018

1 reference

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

21 January 2018

1 reference

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

21 January 2018

1 reference

Molecular heterogeneity in glioblastoma: therapeutic opportunities and challenges

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/FON.12.51

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22646770%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

1 reference