(Q34287261)

English

ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate

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scholarly article

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Europe PubMed Central

1 August 2017

ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate (English)

1 reference

Europe PubMed Central

1 August 2017

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author name string

Gui Gao

1

1 reference

Europe PubMed Central

1 August 2017

Anna Plaas

2

1 reference

Europe PubMed Central

1 August 2017

Vivian P Thompson

3

1 reference

Europe PubMed Central

1 August 2017

Sue Jin

4

1 reference

Europe PubMed Central

1 August 2017

Fengrong Zuo

5

1 reference

Europe PubMed Central

1 August 2017

John D Sandy

6

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Europe PubMed Central

1 August 2017

language of work or name

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publication date

29 December 2003

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Europe PubMed Central

1 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

1 August 2017

279

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Europe PubMed Central

1 August 2017

10042-10051

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Europe PubMed Central

1 August 2017

11

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Europe PubMed Central

1 August 2017

describes a project that uses

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How matrix metalloproteinases regulate cell behavior

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Matrix Metalloproteinase Inhibitors and Cancer--Trials and Tribulations

1 reference

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21 January 2018

Invasive properties of fibroblast-like synoviocytes: correlation with growth characteristics and expression of MMP-1, MMP-3, and MMP-10.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Expression and regulation of aggrecanase in arthritis: the role of TGF-beta

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Cloning, expression, and functional characterization of the von Willebrand factor-cleaving protease (ADAMTS13).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

cDNA cloning and the identification of an aggrecanase-like cleavage site in rat brevican.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Sequence motifs of tissue inhibitor of metalloproteinases 2 (TIMP-2) determining progelatinase A (proMMP-2) binding and activation by membrane-type metalloproteinase 1 (MT1-MMP).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Activation of the proteolytic activity of ADAMTS4 (aggrecanase-1) by C-terminal truncation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Non-proteoglycan forms of biglycan increase with age in human articular cartilage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Autocatalytic cleavage of ADAMTS-4 (Aggrecanase-1) reveals multiple glycosaminoglycan-binding sites

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Keratan sulfate disaccharide composition determined by FACE analysis of keratanase II and endo-beta-galactosidase digestion products

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Overview of expression of matrix metalloproteinases (MMP-17, MMP-18, and MMP-20) in cultured human cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Catalytic activities of membrane-type 6 matrix metalloproteinase (MMP25).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor-alpha convertase activity but does not activate pro-MMP2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Structural characterization of heparan sulfate and chondroitin sulfate of syndecan-1 purified from normal murine mammary gland epithelial cells. Common phosphorylation of xylose and differential sulfation of galactose in the protein linkage region t

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Transforming growth factor (type beta) promotes the addition of chondroitin sulfate chains to the cell surface proteoglycan (syndecan) of mouse mammary epithelia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Effects of long-term exposure to glucosamine and mannosamine on aggrecan degradation in articular cartilage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

N-terminal sequence of proteoglycan fragments isolated from medium of interleukin-1-treated articular-cartilage cultures. Putative site(s) of enzymic cleavage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the 'aggrecanase' and the MMP sites. Characterization of MT1-MMP catabolic activities on the interglobular domain of aggrecan

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Expression and activity of ADAMTS-5 in synovium

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Cell-mediated catabolism of aggrecan. Evidence that cleavage at the "aggrecanase" site (Glu373-Ala374) is a primary event in proteolysis of the interglobular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Cytokine-induced cartilage proteoglycan degradation is mediated by aggrecanase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Mechanisms involved in cartilage proteoglycan catabolism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

The mechanism of aggrecan release from cartilage differs with tissue origin and the agent used to stimulate catabolism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Decreased activity and enhanced nuclear export of CCAAT-enhancer-binding protein beta during inhibition of adipogenesis by ceramide

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Soluble recombinant neprilysin induces aggrecanase-mediated cleavage of aggrecan in cartilage explant cultures

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Inhibition of interleukin 1-stimulated cartilage proteoglycan degradation by a lipophilic inactivator of cysteine endopeptidases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

A serine proteinase inactivator inhibits chondrocyte-mediated cartilage proteoglycan breakdown occurring in response to proinflammatory cytokines

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Active site determination of Gpi8p, a caspase-related enzyme required for glycosylphosphatidylinositol anchor addition to proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

ADAMTS4 (aggrecanase-1) cleaves human brain versican V2 at Glu405-Gln406 to generate glial hyaluronate binding protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Association between protease-specific proteolytic cleavage of brevican and synaptic loss in the dentate gyrus of kainate-treated rats

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Lecticans: organizers of the brain extracellular matrix

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Highly sulfated glycosaminoglycans inhibit aggrecanase degradation of aggrecan by bovine articular cartilage explant cultures

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing i

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Factors regulating collagen synthesis and degradation during second-intention healing of wounds in the thoracic region and the distal aspect of the forelimb of horses

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Activation of proMMP-9 by a plasmin/MMP-3 cascade in a tumor cell model. Regulation by tissue inhibitors of metalloproteinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Inhibition of cartilage degradation and changes in physical properties induced by IL-1beta and retinoic acid using matrix metalloproteinase inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Chondrocyte-mediated catabolism of aggrecan: evidence for a glycosylphosphatidylinositol-linked protein in the aggrecanase response to interleukin-1 or retinoic acid

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Mannosamine inhibits aggrecanase-mediated changes in the physical properties and biochemical composition of articular cartilage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

The interglobular domain of cartilage aggrecan is cleaved by hemorrhagic metalloproteinase HT-d (atrolysin C) at the matrix metalloproteinase and aggrecanase sites

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Induction of aggrecanase 1 (ADAM-TS4) by interleukin-1 occurs through activation of constitutively produced protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Aggrecanase. A target for the design of inhibitors of cartilage degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312100200

21 January 2018

Identifiers

10.1074/JBC.M312100200

1 reference

Europe PubMed Central

1 August 2017

1 reference

Europe PubMed Central

1 August 2017

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