(Q34293607)

1 August 2017

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title

Replication-selective oncolytic adenoviruses: virotherapy aimed at genetic targets in cancer (English)

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1 August 2017

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1 reference

Kirn D

1

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PubMed ID

11426652

1 August 2017

language of work or name

English

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publication date

1 December 2000

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1 August 2017

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1 August 2017

19

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1 August 2017

6660-6669

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1 August 2017

56

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1204094

1 August 2017

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Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection

21 January 2018

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An adenovirus mutant that replicates selectively in p53-deficient human tumor cells

21 January 2018

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Adenovirus 2 Ip+ locus codes for a 19 kd tumor antigen that plays an essential role in cell transformation.

21 January 2018

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Reovirus therapy of tumors with activated Ras pathway

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Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor

21 January 2018

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Tumor-specific, replication-competent adenovirus vectors overexpressing the adenovirus death protein

21 January 2018

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Targeted gene delivery by tropism-modified adenoviral vectors

21 January 2018

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A novel three-pronged approach to kill cancer cells selectively: concomitant viral, double suicide gene, and radiotherapy

21 January 2018

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A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo.

21 January 2018

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A novel tumor-specific replication-restricted adenoviral vector for gene therapy of hepatocellular carcinoma

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Replication-selective adenoviruses as oncolytic agents

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ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

21 January 2018

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Gene delivery from replication-selective viruses: arming guided missiles in the war against cancer

21 January 2018

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p53 mutations in human cancers

21 January 2018

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a controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

21 January 2018

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Replication-selective microbiological agents: fighting cancer with targeted germ warfare

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A tale of two trials: selectively replicating herpesviruses for brain tumors

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Selectivity of a replication-competent adenovirus for human breast carcinoma cells expressing the MUC1 antigen.

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Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015).

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Identification of a conserved receptor-binding site on the fiber proteins of CAR-recognizing adenoviridae

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Deletion of the adenoviral E1b-19kD gene enhances tumor cell killing of a replicating adenoviral vector

21 January 2018

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The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines

21 January 2018

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Clinical studies of viruses as antineoplastic agents with particular reference to Egypt 101 virus

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Use of preferentially replicating bacteria for the treatment of cancer

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Herpes simplex virus as an in situ cancer vaccine for the induction of specific anti-tumor immunity

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The E3-11.6-kDa adenovirus death protein (ADP) is required for efficient cell death: characterization of cells infected with adp mutants

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Cellular targets for transformation by the adenovirus E1A proteins

21 January 2018

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Adenovirus proteins that subvert host defenses

21 January 2018

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Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53.

21 January 2018

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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

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Adenovirus E3-10.4K/14.5K protein complex inhibits tumor necrosis factor-induced translocation of cytosolic phospholipase A2 to membranes

21 January 2018

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7 January 2021

The early region 1B 55-kilodalton oncoprotein of adenovirus relieves growth restrictions imposed on viral replication by the cell cycle

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204094

7 January 2021

p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection

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7 January 2021

An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy

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7 January 2021

Efficacy of a replication-competent adenovirus (ONYX-015) following intratumoral injection: intratumoral spread and distribution effects

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7 January 2021

ONYX-015: clinical data are encouraging

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7 January 2021

Lipid A mutant Salmonella with suppressed virulence and TNFalpha induction retain tumor-targeting in vivo.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204094

7 January 2021

Targeted adenovirus gene transfer to endothelial and smooth muscle cells by using bispecific antibodies

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204094

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1204094

1 reference

PubMed ID

11426652

Dimensions Publication ID

1 August 2017

0 references

1 reference

PubMed ID

11426652