(Q34295673)

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Estradiol attenuates ischemia-induced death of hippocampal neurons and enhances synaptic transmission in aged, long-term hormone-deprived female rats

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Europe PubMed Central

PubMed publication ID

1 August 2017

Estradiol attenuates ischemia-induced death of hippocampal neurons and enhances synaptic transmission in aged, long-term hormone-deprived female rats (English)

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Pablo E Castillo

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Pablo E Castillo

4

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author name string

Tomoko Inagaki

1

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Naoki Kaneko

2

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

R Suzanne Zukin

3

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

Anne M Etgen

5

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Europe PubMed Central

PubMed publication ID

1 August 2017

language of work or name

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publication date

4 June 2012

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Europe PubMed Central

PubMed publication ID

1 August 2017

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

7

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

e38018

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

copyright license

Creative Commons Attribution 4.0 International

4 June 2012

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April 2022 Public Data File from Crossref

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G-protein-coupled receptor 30 mediates rapid neuroprotective effects of estrogen via depression of NR2B-containing NMDA receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Estrogen neuroprotection and the critical period hypothesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Estrogen synthesis in the hippocampus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Oestrogen signalling and neuroprotection in cerebral ischaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Mechanisms of estrogens' dose-dependent neuroprotective and neurodamaging effects in experimental models of cerebral ischemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Long-Term Potentiation at CA3-CA1 Hippocampal Synapses with Special Emphasis on Aging, Disease, and Stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

STX, a novel nonsteroidal estrogenic compound, induces rapid action in primate GnRH neuronal calcium dynamics and peptide release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

The ovarian hormone estradiol plays a crucial role in the control of food intake in females

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Overweight worsens apoptosis, neuroinflammation and blood-brain barrier damage after hypoxic ischemia in neonatal brain through JNK hyperactivation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Physiological consequences of membrane-initiated estrogen signaling in the brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Neuroprotective actions of estradiol and novel estrogen analogs in ischemia: translational implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Estradiol acutely potentiates hippocampal excitatory synaptic transmission through a presynaptic mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

The assessment of non-feminizing estrogens for use in neuroprotection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Duration of estrogen deprivation, not chronological age, prevents estrogen's ability to enhance hippocampal synaptic physiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Effects of estrogen and aging on the synaptic distribution of phosphorylated Akt-immunoreactivity in the CA1 region of the female rat hippocampus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

The science of stroke: mechanisms in search of treatments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

The neurotoxic effects of estrogen on ischemic stroke in older female rats is associated with age-dependent loss of insulin-like growth factor-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Ischemic stroke in the elderly: an overview of evidence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Estradiol and G1 reduce infarct size and improve immunosuppression after experimental stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Acute estradiol protects CA1 neurons from ischemia-induced apoptotic cell death via the PI3K/Akt pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Acute administration of non-classical estrogen receptor agonists attenuates ischemia-induced hippocampal neuron loss in middle-aged female rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Neuronal estrogen receptor-alpha mediates neuroprotection by 17beta-estradiol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Modulation of synaptic plasticity by brain estrogen in the hippocampus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Estrogen attenuates ischemic oxidative damage via an estrogen receptor alpha-mediated inhibition of NADPH oxidase activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

A surprising link between the energetics of ovariectomy-induced weight gain and mammary tumor progression in obese rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Neuroprotective actions of brain aromatase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Estradiol rescues neurons from global ischemia-induced cell death: multiple cellular pathways of neuroprotection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Chronic estradiol treatment increases CA1 cell survival but does not improve visual or spatial recognition memory after global ischemia in middle-aged female rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Reproductive age modulates the impact of focal ischemia on the forebrain as well as the effects of estrogen treatment in female rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Estrogen synthesis in the brain--role in synaptic plasticity and memory.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Estrogen signaling through the transmembrane G protein-coupled receptor GPR30.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Estradiol, insulin-like growth factor-I and brain aging.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Membrane-initiated signaling of estrogen in the brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Timing of estrogen therapy after ovariectomy dictates the efficacy of its neuroprotective and antiinflammatory actions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Dose dependence and therapeutic window for the neuroprotective effects of 17beta-estradiol when administered after cerebral ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

MAPK signaling is critical to estradiol protection of CA1 neurons in global ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Acute effects of estrogen on neuronal physiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Hippocampal synthesis of estrogens and androgens which are paracrine modulators of synaptic plasticity: synaptocrinology.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Effects of combined estrogen and progesterone on brain infarction in reproductively senescent female rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

The use of estrogens and related compounds in the treatment of damage from cerebral ischemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017alpha and P450 aromatase localized in neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Estrogen and the Aging Hippocampal Synapse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Aromatase Cytochrome P450 and Extragonadal Estrogen Play a Role in Ischemic Neuroprotection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Menopause and ischaemic stroke: basic, clinical and epidemiological considerations. The role of hormone replacement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Different modes of hippocampal plasticity in response to estrogen in young and aged female rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Long-term treatment with estrogen and progesterone enhances acquisition of a spatial memory task by ovariectomized aged rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Neuroprotective effects of female gonadal steroids in reproductively senescent female rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Delayed neuronal death in the gerbil hippocampus following ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Selective vulnerability of the hippocampus to ischemia--reversible and irreversible types of ischemic cell damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Selective vulnerability of the hippocampus in brain ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

A new model of bilateral hemispheric ischemia in the unanesthetized rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

6 July 2018

Conjugated equine estrogens and global cognitive function in postmenopausal women: Women's Health Initiative Memory Study

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038018

21 January 2018

A clinical trial of estrogen-replacement therapy after ischemic stroke

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038018

21 January 2018

Neuroprotective effects of estrogen treatment on ischemia-induced behavioural deficits in ovariectomized gerbils at different ages.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038018

21 January 2018

Estrogen can act via estrogen receptor alpha and beta to protect hippocampal neurons against global ischemia-induced cell death.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038018

21 January 2018

Effects of gender and estradiol treatment on focal brain ischemia

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038018

21 January 2018

Comparison between hippocampus-synthesized and circulation-derived sex steroids in the hippocampus.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038018

21 January 2018

Neural 17β-estradiol facilitates long-term potentiation in the hippocampal CA1 region.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038018

21 January 2018

Aromatase inhibitors induce spine synapse loss in the hippocampus of ovariectomized mice

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038018

21 January 2018

Neurosteroid synthesis in the hippocampus: role in synaptic plasticity

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038018

21 January 2018

Brain aromatase expression after experimental stroke: topography and time course.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038018

21 January 2018

Estrogen synthesis in the central nucleus of the amygdala following middle cerebral artery occlusion: role in modulating neurotransmission

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038018

21 January 2018

High expression of GLT-1 in hippocampal CA3 and dentate gyrus subfields contributes to their inherent resistance to ischemia in rats.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038018

21 January 2018

Enhanced cell death and learning deficits after a mini-stroke in aged hippocampus

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038018

21 January 2018

Age-related susceptibility to oxygen and glucose deprivation damage in rat hippocampal slices.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038018

21 January 2018

Increased sensitivity to transient global ischemia in aging rat brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

28 October 2018

Estrogen and aging affect the subcellular distribution of estrogen receptor-alpha in the hippocampus of female rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366987

28 October 2018

Estradiol exerts neuroprotective effects when administered after ischemic insult

1 reference

https://pubmed.ncbi.nlm.nih.gov/22675505

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-dependent increase in infarct volume following photochemically induced cerebral infarction: putative role of astroglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22675505

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogen receptor beta agonist diarylpropiolnitrile (DPN) does not mediate neuroprotection in a rat model of permanent focal ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22675505

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1371/JOURNAL.PONE.0038018

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

2012PLoSO...738018I

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

ResearchGate publication ID

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